其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Aluminum b -Naphtholdisulfonate CAS Registry Number: 1300-81-8

CAS Name: 2-Hydroxynaphthalenedisulfonic acid aluminum salt
Percent Composition: C 37.50%, H 1.89%, Al 5.62%, O 34.97%, S 20.02%
Literature References: Antiseptic. Prepd from barium b-naphtholdisulfonate and aluminum sulfate: Hagers Handb. Pharm. Praxis Band 1, 204 (Berlin, 1930).

Ambucetamide CAS Registry Number: 519-88-0 氨布醋胺

CAS Name: a-(Dibutylamino)-4-methoxybenzeneacetamide
Additional Names: a-dibutylamino-a-(p-methoxyphenyl)acetamide; a-p-methoxyphenyl-a-di-n-butylaminoacetamidePercent Composition: C 69.82%, H ...
Literature References: Antispasmodic. Prepn starting with dibutylamine, anisaldehyde and potassium cyanide: Janssen, J. Am. Chem. Soc. 76, 6192 (1954).

Beclotiamine CAS Registry Number: 13471-78-8 维生素B1杂质3

CAS Name: 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-chloroethyl)-4-methylthiazolium chloride
Additional Names: 5-chloroethylthiamine; chlorothiamine; clotiamine; CT
Trademarks: Coccide...
Literature References: Antithiamine compound derived from thiamine; developed as an anticoccidial for chickens: Inone et al., J. Jpn. Vet. Med. Assoc. 20, 293 (1967); GB 1141055; M. Nagawa et al., US 3786147 (1969, 1974 both to Sankyo); Matsuzawa, Jpn. J. Vet. Sci. 34, 157 (1972), C.A. 78, 23930c (1973). Metabolism and mechanism of action studies: Shindo, Komai, J. Vitaminol. 18, 41-62, 102, 172, 218 (1972). Safety studies: Matsuzawa et al., Sankyo Kenkyusho Nempo 23, 192 (1971), C.A. 77, 28983m (1972).

Nucleocidin CAS Registry Number: 24751-69-7 核杀菌素

CAS Name: 4'-C-Fluoroadenosine 5'-sulfamate
Additional Names: 9-(4-fluoro-5-O-sulfamoylpentofuranosyl)adenine; 4'-fluoro-5'-O-sulfamoyladenosine
Percent Composition: C 32.97%, H 3.60%, F 5.2...
Literature References: Antitrypanosomal antibiotic produced by Streptomyces calvus. The first naturally occurring derivative of a fluoro sugar. Isoln and activity studies: Thomas et al., Antibiot. Annu. 1956-1957, 716; Hewitt et al., ibid. 722. Partial structure: Waller et al., J. Am. Chem. Soc. 79, 1011 (1957). Revised formula and structure: Morton et al., ibid. 91, 1535 (1969). Synthesis: Jenkins et al., ibid. 93, 4323 (1971).

Tuberin CAS Registry Number: 53643-53-1

CAS Name: N-[2-(4-Methoxyphenyl)ethenyl]formamide
Additional Names: N-trans-(p-methoxystyryl)formamide; N-formyl trans-p-methoxystyrylamine
Percent Composition: C 67.78%, H 6.26%, N 7.90%, O...
Literature References: Antitubercular antibiotic isolated from the broth filtrate of Streptomyces amakusaensis: Ohkuma et al., J. Antibiot. 15A, 115 (1962); Sumiki et al., JP 64 7399 (1964 to Inst. Phys. Chem. Res.), C.A. 62, 8355g (1965). Structure and synthesis: Anzai et al., J. Antibiot. 15A, 110, 117, 123 (1962). Alternate synthesis: I. J. Massey, I. T. Harrison, Chem. Ind. (London) 1977, 920. Biosynthetic studies: K. M. Cable et al., J. Chem. Soc. Perkin Trans. 1 1987, 1593.

HON CAS Registry Number: 4439-84-3 2-氨基-5-羟基乙酰丙酸

CAS Name: 5-hydroxy-4-oxonorvaline
Additional Names: 2-amino-5-hydroxylevulinic acid; d-hydroxy-g-oxo-L-norvaline; 2-amino-5-hydroxy-4-oxopentanoic acid
Percent Composition: C 40.82%, H 6.17...
Literature References: Antitubercular antibiotic substance isolated from Streptomyces akiyoshiensis nova sp.: Tatsuoka et al., J. Antibiot. 14A, 39 (1961). Synthesis and structure: Miyake, Chem. Pharm. Bull. 8, 1071, 1074, 1079 (1960).

Lonidamine CAS Registry Number: 50264-69-2 氯尼达明

CAS Name: 1-[(2,4-Dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid
Additional Names: 1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid; diclondazolic acid; DICATrademarks: Doridamina (An...
Literature References: Antitumor agent with antispermatogenic activity; inhibits cellular respiration in neoplastic cells. Prepn: G. Palazzo, B. Silvestrini, DE 2310031; eidem, US 3895026 (1973, 1975 both to Angelini Francesco); G. Corsi, G. Palazzo, J. Med. Chem. 19, 778 (1976). Antispermatogenic activity: T. J. Lobl, Arch. Androl. 2, 353 (1979). In vitro and in vivo antitumor activity: B. Silvestrini et al., Br. J. Cancer 47, 221 (1983). Mechanism of action in neoplastic cells: A. Floridi et al., Exp. Mol. Pathol. 42, 293 (1985). Pharmacology: V. Cioli et al., Arzneim.-Forsch. 34, 455 (1984). HPLC determn in plasma and urine: R. Leclaire et al., J. Chromatogr. 277, 427 (1983). Toxicological study: R. Heywood et al., Chemotherapy (Basel) 27, Suppl. 2, 91 (1981). Series of articles on mechanism of action, pharmacokinetics and clinical applications in spermatogenesis and tumors: ibid. 5-120; on pharmacology and clinical evaluation in cancers: Oncology 41, Suppl. 1, 1-121 (1984). Symposium on clinical evaluations in cancers: Semin. Oncol. 18, Suppl 4, 1-72 (1991).

Vinblastine CAS Registry Number: 865-21-4 长春质碱

CAS Name: Vincaleukoblastine
Additional Names: VLB
Percent Composition: C 68.13%, H 7.21%, N 6.91%, O 17.76%
Literature References: Antitumor alkaloid isolated from periwinkle, Vinca rosea Linn., Apocynaceae; inhibits microtubule assembly. Identification: R. L. Noble et al., Ann. N.Y. Acad. Sci. 76, 882-894 (1958). Isolation and characterization: M. Gorman et al., J. Am. Chem. Soc. 81, 4745, 4754 (1959); C. T. Beer et al., US 3097137 (1963 to CPD Ltd.). Structure: N. Neuss et al., J. Am. Chem. Soc. 86, 1440 (1964). 13C-NMR spectral analysis: E. Wenkert et al., Helv. Chim. Acta 58, 1560 (1975). Synthesis from catharanthine and vindoline, q.q.v.: P. Mangeney et al., J. Am. Chem. Soc. 101, 2243 (1979); J. P. Kutney et al., Heterocycles 27, 1845 (1988). Enantioselective synthesis: M. E. Kuehne et al., J. Org. Chem. 56, 513 (1991). Toxicology: C. Lu, M. Meistrich, Cancer Res. 39, 3575 (1979). Clinical trial in combination with bleomycin, methotrexate, q.q.v. in Hodgkin's disease: P. G. Gobbi et al., J. Clin. Oncol. 14, 527 (1996). Review of pharmacology, toxicology and pharmacokinetics: W. P. Brade, Beitr. Onkol. 6, 95-123 (1981). Comprehensive description: F. J. Muhtadi, A. F. A. Afify, Anal. Profiles Drug Subs. Excip. 21, 611-658 (1992).

Vincristine CAS Registry Number: 57-22-7 长春新碱

CAS Name: 22-Oxovincaleukoblastine
Additional Names: leurocristine; VCR; LCR
Percent Composition: C 66.97%, H 6.84%, N 6.79%, O 19.39%
Literature References: Antitumor alkaloid isolated from Vinca rosea Linn. (Catharanthus roseus G. Don), Apocynaceae: Svoboda, Lloydia 24, 173 (1961). Structure: Neuss et al., J. Am. Chem. Soc. 86, 1440 (1964); Moncrief, Lipscomb, ibid. 87, 4963 (1965). Pharmacology: R. H. Adamson et al., Arch. Int. Pharmacodyn. Ther. 157, 299 (1965); S. M. Sieber et al., Cancer Treat. Rep. 60, 127 (1976). Prepn and pharmacology of [3H]vincristine: Owellen, Donigian, J. Med. Chem. 15, 894 (1972). Symposium on vincristine: Cancer Chemother. Rep. 52, 453-535 (1968). Biosynthesis from catharanthine and vindoline, q.q.v.: A. Rahman et al., Tetrahedron Lett. 1976, 2351; P. Mangeney et al., J. Am. Chem. Soc. 101, 2243 (1979). Comprehensive description of the sulfate: J. H. Burns, Anal. Profiles Drug Subs. 1, 463-480 (1972); F. J. Muhtadi, A. F. A. Afify, Anal. Profiles Drug Subs. Excip. 22, 517-533 (1993).

Demecolcine CAS Registry Number: 477-30-5 秋水仙胺

CAS Name: 6,7-Dihydro-1,2,3,10-tetramethoxy-7-(methylamino)benzo[a]heptalen-9(5H)-one
Additional Names: N-deacetyl-N-methylcolchicine; N-methyl-N-desacetylcolchicine; colchamine; Santavy's subs...
Literature References: Antitumor alkaloid; depolymerizes microtubules and inhibits spindle formation during metaphase. Isoln from Colchicum autumnale L., Liliaceae: Santavy, Pharm. Acta Helv. 25, 248 (1950); Santavy, Reichstein, Helv. Chim. Acta 33, 1606 (1950); Schlittler, Uffer, DE 936268 (1955 to Ciba), C.A. 53, 1396 (1959). Structure: Santavy et al., Helv. Chim. Acta 36, 1319 (1953). Synthesis: Uffer et al., ibid. 37, 18 (1954); H. G. Capraro, A. Brossi, ibid. 62, 965 (1979). Effect on the mitotic cycle: C. L. Rieder, R. E. Palazzo, J. Cell Sci. 102, 387 (1992). Use in oocyte enucleation: E. Ibáñez et al., Biol. Reprod. 68, 1249 (2003).