其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Picolinafen CAS Registry Number: 137641-05-5 氟吡酰草胺

CAS Name: N-(4-Fluorophenyl)-6-[3-(trifluoromethyl)phenoxy]-2-pyridinecarboxamide
Additional Names: 4'-fluoro-6-[(a,a,a-trifluoro-m-tolyl)oxy]picolinanilideTrademarks: Pico (BASF)
Percent Co...
Literature References: Aryloxypicolinamide herbicide for use in barley and wheat. Inhibits phytoene desaturase, an enzyme involved in carotenoid biosynthesis. Prepn: C. J. Foster et al., EP 447004; eidem, US 5294597 (1991, 1994 both to Shell). Comprehensive description of properties and field trials: R. H. White et al., Brighton Crop Prot. Conf. - Weeds 1999, 47-52.

Sulfentrazone CAS Registry Number: 122836-35-5 甲磺草胺

CAS Name: N-[2,4-Dichloro-5-[4-(difluoromethyl)-4,5-dihydro-3-methyl-5-oxo-1H-1,2,4-triazol-1-yl]phenyl]methanesulfonamide
Additional Names: 2',4'-dichloro-5'-(4-difluoromethyl-4,5-dihydro-3-me...
Literature References: Aryltriazolinone herbicide; inhibits protoporphyrinogen oxidase in the chlorophyll biosynthetic pathway. Prepn: G. Theodoridis, US 4818275 (1989 to FMC); and structure-activity study: idem et al., ACS Symp. Ser. 504, 134 (1992). Metabolism and distribution in animals: L. Y. Leung et al., J. Agric. Food Chem. 39, 1509 (1991). Properties and field trials in soybeans: W. A. Van Saun et al., Brighton Crop Prot. Conf. - Weeds 1991, 77. Field trial in peanuts: W. C. Johnson, III, B. G. Mullinix, Jr., Peanut Sci. 21, 65 (1994).

Chirald CAS Registry Number: 38345-66-3 (2S,3R)-(+)-4-二甲基氨基-1,2-二苯基-3-甲基-2-丁醇,(2S,3R)-(+)-4-二甲基氨基-3-甲基-1,2-二苯基-2-丁醇,右旋甲醇碱

CAS Name: (aS)-a-[(1R)-2-(Dimethylamino)-1-methylethyl]-a-phenylbenzeneethanol
Additional Names: (+)-oxyphene; (2S,3R)-(+)-4-dimethylamino-3-methyl-1,2-diphenyl-2-butanol; Darvon alcohol
Per...
Literature References: Asymmetric reducing agent. Prepn of racemate: W. G. Stoll et al., Helv. Chim. Acta 33, 1194 (1950). Resolution of enantionmers: A. Pohland, H. R. Sullivan, J. Am. Chem. Soc. 77, 3400 (1955). Asymmetric synthesis: T. J. Erickson, J. Org. Chem. 51, 934 (1986). HPLC determn as an impurity in dextropropoxyphene, q.v.: S. Kryger, P. Helboe, J. Chromatogr. 539, 186 (1991). Use as an enantioselective reducing agent: M. N. Nefedova et al., J. Organomet. Chem. 425, 125 (1992); D. R. Williams et al., Tetrahedron Lett. 41, 9397 (2000).

Diflufenzopyr CAS Registry Number: 109293-97-2 氟吡草腙

CAS Name: 2-[1-[[[(3,5-Difluorophenyl)amino]carbonyl]hydrazono]ethyl]-3-pyridinecarboxylic acid
Additional Names: 2-[1-[4-(3,5-difluorophenyl)semicarbazono]ethyl]nicotinic acidPercent Compositi...
Literature References: Auxin transport inhibitor. Prepn: R. J. Anderson, M. M. Leippe, JP Kokai 62 45570; eidem et al., US 5098466 (1987, 1992 both to Sandoz). Synergy with auxin type herbicides: R. G. Lym, K. M. Christianson, Proc. West. Soc. Weed Sci. 51, 59 (1998). Field trial of combination with dicamba in corn: P. H. Sikkema et al., Weed Technol. 13, 283 (1999). Review of physical properties, mode of action, and activity: S. Bowe et al., Brighton Crop Prot. Conf. - Weeds 1999, 35-40.

Fluroxypyr CAS Registry Number: 69377-81-7 氯氟吡氧乙酸

CAS Name: [(4-Amino-3,5-dichloro-6-fluoro-2-pyridinyl)oxy]acetic acid
Percent Composition: C 32.97%, H 1.98%, Cl 27.80%, F 7.45%, N 10.98%, O 18.82%
Literature References: Auxin-type herbicide for use in cereals. Prepn: S. D. McGregor, US 3761486 (1973 to Dow). Description: J. A. Paul et al., Proc. Br. Crop Prot. Conf. - Weeds 1985, 939. Field trials in grassland: A. R. Thompson, ibid. 1987, 735. Mode of action: G. E. Sanders, K. E. Pallet, Ann. Appl. Biol. 111, 385 (1987). HPLC determn: R. G. Lehmann, J. R. Miller, J. Chromatogr. 485, 581 (1989). Persistence in soil: L. F. Bergström et al., Pestic. Sci. 29, 405 (1990). Uptake and metabolism in weeds: R. L. MacDonald et al., Weed Res. 34, 333 (1994).

Quinmerac CAS Registry Number: 90717-03-6 氯甲喹啉酸

CAS Name: 7-Chloro-3-methyl-8-quinolinecarboxylic acidPercent Composition: C 59.61%, H 3.64%, Cl 16.00%, N 6.32%, O 14.44%
Literature References: Auxin-type herbicide. Prepn: H. Hagen et al., DE 3233089; eidem, US 4715889 (1984, 1987 both to BASF). ELISA determn in cereals: R. A. Baumann, V. M. 't Hart-De Kleijn, Meded. Fac. Landbouwwet. Univ. Gent 58, 173 (1993). Mode of action study: K. Grossman, F. Scheltrup, Pestic. Sci. 52, 111 (1998). Field trials in cereals, rapeseed and sugarbeets: W. Nuyken et al., Proc. Br. Crop Prot. Conf. - Weeds 1985, 71. Review: B. Wuerzer et al., ibid. 63-70.

Tetrasodium Pyrophosphate CAS Registry Number: 7722-88-5 无水焦磷酸钠

Additional Names: TSPP; pyro; sodium pyrophosphate
Percent Composition: Na 34.58%, O 42.12%, P 23.30%
Literature References: Available alkalinity as Na2O 4.4%, total alkalinity 22.7%. Produced by molecular dehydration of dibasic sodium phosphate at 500°: Bell, Inorg. Synth. 3, 98 (1950).

Trimethaphan Camsylate CAS Registry Number: 68-91-7 樟磺咪芬

CAS Name: Decahydro-2-oxo-1,3-bis(phenylmethyl)thieno[1',2':1,2]thieno[3,4-d]imidazol-5-ium salt with (1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonic acid (1:1)
Additional Names:...
Literature References: Available from the Roche synthesis of biotin: Randall et al., J. Pharmacol. Exp. Ther. 97, 48 (1949); Scurr, Wyman, Lancet 1, 338 (1954). May be prepd by treating (+)-3,4-(1,3-dibenzylureylene)tetrahydro-2-oxothiophene with 3-ethoxypropylmagnesium bromide, followed by reduction, ring closure, and conversion into the (+)-b-camphorsulfonate. Comprehensive description: K. W. Blessel et al., Anal. Profiles Drug Subs. 3, 545-564 (1974).

BINAP CAS Registry Number: 98327-87-8 1,1'-联萘-2,2'-双二苯膦

CAS Name: [1,1'-Binaphthalene]-2,2'-diylbis[diphenylphosphine]
Additional Names: 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl
Percent Composition: C 84.87%, H 5.18%, P 9.95%
Literature References: Axially disymmetric bis(triaryl)phosphine ligand. Synthesis: A. Miyashita et al., J. Am. Chem. Soc. 102, 7932 (1980); preparative scale synthesis of enantiomers: eidem, Tetrahedron 40, 1245 (1984). Review of asymmetric synthesis by metal-BINAP catalysts: S. Akutagawa, Appl. Catal. A 128, 171-207 (1995). Review of industrial applications: H. Kumobayashi, Rec. Trav. Chim. 115, 201-210 (1996); idem et al., Synlett 2001, S1 1055-1064.

Atazanavir CAS Registry Number: 198904-31-3 阿扎那韦

CAS Name: (3S,8S,9S,12S)-3,12-Bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-[[4-(2-pyridinyl)phenyl]methyl]-2,5,6,10,13-pentaazatetradecanedioic acid dimethyl ester
Additional ...
Literature References: Azapeptide HIV protease inhibitor. Prepn: A. Fässler et al., WO 9740029; eidem, US 5849911 (1997, 1998 both to Novartis); G. Bold et al., J. Med. Chem. 41, 3387 (1998); of bisulfate salt: J. Singh et al., WO 9936404; eidem, US 6087383 (1999, 2000 both to Bristol-Myers Squibb); Z. Xu et al., Org. Process Res. Dev. 6, 323 (2002). Comparative anti-HIV activity: B. S. Robinson et al., Antimicrob. Agents Chemother. 44, 2093 (2000). HPLC determn in plasma: E. Cateau et al., J. Pharm. Biomed. Anal. 39, 791 (2005). Clinical evaluation in HIV: I. Sanne et al., J. Acquired Immune Defic. Synd. 32, 18 (2003). Review of pharmacology and clinical efficacy in HIV: C. Le Tiec et al., Clin. Pharmacokinet. 44, 1035-1050 (2005); T. S. Harrison, L. J. Scott, Drugs 65, 2309-2336 (2005).