其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
备注: 根据相关法律法规, 本站点不显示有法律约束管制的产品, 如有遗漏, 请自行鉴别,或提交我们及时更新撤除.
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

其它产品项目整合

Dioxethedrine CAS Registry Number: 497-75-6 二羟西君

CAS Name: 4-[2-(Ethylamino)-1-hydroxypropyl]-1,2-benzenediol
Additional Names: N-ethyl-3,4-dihydroxynorephedrine; a-(1-ethylaminoethyl)protocatechuyl alcohol; 2-ethylamino-1-(3',4'-dihydroxyphe...
Literature References: b-Adrenergic agonist. Prepd by catalytic hydrogenation of the corresponding aminoketone: Lespagnol, Cuingnet, Ann. Pharm. Fr. 18, 445 (1960). Only one of the two possible isomers, believed to be the "erythro" form, was isolated.

Protokylol CAS Registry Number: 136-70-9 普罗托醇

CAS Name: 4-[2-[[2-(1,3-Benzodioxol-5-yl)-1-methylethyl]amino]-1-hydroxyethyl]-1,2-benzenediol
Additional Names: a-[(a-methyl-3,4-methylenedioxyphenethylamino)methyl]protocatechuyl alcohol; a-(...
Literature References: b-Adrenergic agonist. Prepn: Biel et al., J. Am. Chem. Soc. 76, 3149 (1954); Biel, US 2900415 (1959 to Lakeside Labs.). Toxicity: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).

Zilpaterol CAS Registry Number: 119520-05-7 齐帕特罗

CAS Name: (6R,7R)-rel-4,5,6,7-Tetrahydro-7-hydroxy-6-[(1-methylethyl)amino]imidazo[4,5,1-jk][1]benzazepin-2(1H)-one
Additional Names: (±)-trans-4,5,6,7-tetrahydro-7 hydroxy-6-(isopropylami...
Literature References: b-Adrenergic agonist. Prepn: D. Fréchet et al., FR 2534257; eidem, US 4585770 (1984, 1986 both to Roussel Uclaf). Effects on growth performance and carcass characteristics of steers: A. Plascencia et al., Proc. West. Sect. Am. Soc. Anim. Sci. 50, 331-334 (1999). GC/MS determn in commercial feeds: B. Bocca et al., J. Chromatogr. B 783, 141 (2003); in calf eye: idem et al., J. AOAC Int. 86, 8 (2003). Residue analysis in cattle and pigs: C. S. Stachel et al., Anal. Chim. Acta 493, 63 (2003). ELISA screening method: W. L. Shelver, D. J. Smith, J. Agric. Food Chem. 52, 2159 (2004).

Terbutaline CAS Registry Number: 23031-25-6 特布他林

CAS Name: 5-[2-[(1,1-Dimethylethyl)amino]-1-hydroxyethyl]-1,3-benzenediol
Additional Names: a-[(tert-butylamino)methyl]-3,5-dihydroxybenzyl alcohol; 1-(3,5-dihydroxyphenyl)-2-(tert-butylamino)e...
Literature References: b-Adrenergic agonist. Prepn: K. Wetterlin, L. A. Svensson, BE 704932; eidem, US 3937838 (1968, 1976 both to Draco). Pharmacology: Bergman et al., Experientia 25, 899 (1969). Resolution of isomers and activity studies: K. Wetterlin, J. Med. Chem. 15, 1182 (1972). Clinical study in treatment of preterm labor: S. N. Caritis et al., Am. J. Obstet. Gynecol. 150, 7 (1984). Review: J. J. McPhillips in Pharmacological and Biochemical Properties of Drug Substances vol. 1, M. E. Goldberg, Ed. (Am. Pharm. Assoc., Washington, DC, 1977) pp 311-328. Review of clinical toxicology: J. D. Truwit, Crit. Care Clin. 7, 639-657 (1991). Comprehensive description: S. Ahuja, J. Ashman, Anal. Profiles Drug Subs. 19, 601-625 (1990).

Albuterol CAS Registry Number: 18559-94-9 沙丁胺醇

CAS Name: a1-[[(1,1-Dimethylethyl)amino]methyl]-4-hydroxy-1,3-benzenedimethanol
Additional Names: a1-[(tert-butylamino)methyl]-4-hydroxy-m-xylene-a,a'-diol; 2-(tert-butylamino)-1-(4-hydroxy-3-h...
Literature References: b-Adrenergic agonist. Prepn: L. H. C. Lunts et al., ZA 6705591; eidem, US 3644353 (1968, 1972 both to Allen Hanburys). Synthesis and structure-activity studies: D. T. Collin et al., J. Med. Chem. 13, 674 (1970). Prepn of isomers: C. J. Hawkins, G. T. Klease, ibid. 16, 856 (1973); R. P. Bakale, Spec. Chem. 15, 249 (1995). Absolute configuration of isomers: D. Hartley, D. Middlemiss, J. Med. Chem. 14, 895 (1971). Pharmacology: R. T. Brittain et al., Nature 219, 862 (1968); V. A. Cullum et al., Br. J. Pharmacol. 35, 141 (1969). Metabolism: L. E. Martin et al., Eur. J. Pharmacol. 14, 183 (1971). Clinical comparison of levalbuterol with racemate: H. S. Nelson et al., J. Allergy Clin. Immunol. 102, 943 (1998). Comprehensive description: H. Y. Aboul-Enein et al., Anal. Profiles Drug Subs. 10, 665-689 (1981). Review of clinical experience in asthma and in preterm labor: A. H. Price, S. P. Clissold, Drugs 38, 77-122 (1989); of toxicology: S. E. Libretto, Arch. Toxicol. 68, 213-216 (1994). Review of clinical trials for add-on therapy to inhaled steroids: S. Shrewsbury et al., Br. Med. J. 320, 1368-1373 (2000).

Soterenol CAS Registry Number: 13642-52-9 索特瑞醇

CAS Name: N-[2-Hydroxy-5-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]methanesulfonamide
Additional Names: 2'-hydroxy-5'-[1-hydroxy-2-(isopropylamino)ethyl]methanesulfonanilidePercent Compos...
Literature References: b-Adrenergic agonist. Prepn: Larsen et al., J. Med. Chem. 10, 462 (1967). Pharmacological study: K. W. Dungan et al., J. Pharmacol. Exp. Ther. 164, 290 (1968).

Clorprenaline CAS Registry Number: 3811-25-4 氯丙那林

CAS Name: 2-Chloro-a-[[(1-methylethyl)amino]methyl]benzenemethanol
Additional Names: o-chloro-a-(isopropylaminomethyl)benzyl alcohol; 1-(o-chlorophenyl)-2-isopropylaminoethanol; N-(b-o-chloroph...
Literature References: b-Adrenergic agonist. Prepn: Mills, US 2816059 (1957 to Lilly); Nash, US 2887509 (1959 to Lilly).

Methoxyphenamine CAS Registry Number: 93-30-1 甲氧那明

CAS Name: 2-Methoxy-N,a-dimethylbenzeneethanamime
Additional Names: o-methoxy-N,a-dimethylphenethylamine; b-(o-methoxyphenyl)isopropylmethylamine; a-(2-methoxyphenyl)-b-methylaminopropane
Pe...
Literature References: b-Adrenergic agonist. Prepn: Woodruff et al., J. Am. Chem. Soc. 62, 922 (1940); Heinzelman, ibid. 75, 921 (1953); Morishita, JP 61 2921 (1961 to Nippon Shinyaku), C.A. 55, 24677f (1961).

Ractopamine CAS Registry Number: 97825-25-7 莱克多巴胺

CAS Name: 4-Hydroxy-a-[[[3-(4-hydroxyphenyl)-1-methylpropyl]amino]methyl]benzenemethanol
Additional Names: 1-(4-hydroxyphenyl)-2-[1-methyl-3-(4-hydroxyphenyl)-propylamino]ethanol; N-[2-(4-hydro...
Literature References: b-Adrenergic agonist; repartitioning agent. Prepn (stereochemistry unspecified): J. van Dijk, H. D. Moed, Rec. Trav. Chim. 92, 1281 (1973). Prepn of R,R-isomer: J. Mills et al., EP 7205 (1980 to Lilly). Prepd (not claimed): D. B. Anderson et al., US 4690951 (1987 to Lilly). LC determn in animal feeds: M. P. Turberg et al., J. AOAC Int. 77, 840 (1994). Metabolism and tissue residue studies: J. E. Dalidowicz et al., ACS Symp. Ser. 503, 234 (1992). Effect on growth, carcass characteristics and meat quality in swine: B. E. Uttaro et al., J. Anim. Sci. 71, 2439 (1993). Effect on b-receptor affinity and density in pigs: M. E. Spurlock et al., ibid. 72, 75 (1994).

Bufuralol CAS Registry Number: 54340-62-4 丁呋洛尔

CAS Name: a-[[(1,1-Dimethylethyl)amino]methyl]-7-ethyl-2-benzofuranmethanol
Additional Names: a-[(tert-butylamino)methyl]-7-ethyl-2-benzofuranmethanol; 2-(2-tert-butylamino-1-hydroxyethyl)-7-et...
Literature References: b-Adrenergic blocker with peripheral vasodilating activity. Prepn: NL 6606441; G. A. Fothergill et al., US 3929836 (1966, 1975 both to Hoffmann-La Roche). Prepn and resolution of isomers: eidem, Experientia 31, 1322 (1975); eidem, Arzneim.-Forsch. 27, 981 (1977). Pharmacology: T. C. Hamilton, M. W. Parkes, ibid. 1410. HPLC determn in plasma: P. Haefelfinger, J. Chromatogr. 221, 327 (1980). Metabolism of isomers and racemate: R. J. Francis et al., Eur. J. Clin. Pharmacol. 23, 529 (1982). Pharmacokinetics in hypertensive patients: M. Eckert et al., ibid. 24, 479 (1983). Hemodynamic effects in patients with angina: M. Pfisterer et al., J. Cardiovasc. Pharmacol. 6, 417 (1984).