其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Diphosgene CAS Registry Number: 503-38-8 氯甲酸三氯甲酯

CAS Name: Carbonochloridic acid trichloromethyl ester
Additional Names: chloroformic acid trichloromethyl ester; trichloromethylchloroformate; trichloromethylcarbonochloridate
Percent Compos...
Literature References: Used in synthesis as substitute for phosgene, q.v. Prepn by photochlorination of methyl formate: W. Hentschel, J. Prakt. Chem. 36, 209 (1887); F. Grignard et al., C.R. Hebd. Seances Acad. Sci. 169, 1074 (1919); eidem, ibid. 1143; by photochlorination of methyl chloroformate: A. Kling et al., ibid. 1046; K. Kurita, Y. Iwakura, Org. Synth. 59, 195 (1980). Effect on air-blood barrier in rabbits, toxicity: E. Klika, A. Mysliveckova, Folia Morphol. (Prague) 19, 5 (1971), C.A. 75, 3433c (1971). Use in synthesis of isocyanides: G. Skorna, J. Ugi, Angew. Chem. Int. Ed. 16, 259 (1977).

Oxalomolybdic Acid CAS Registry Number: 53450-33-2

CAS Name: [Ethanedioato(2-)-O,O']trioxomolybdate(2-) dihydrogen
Additional Names: [ethanedioato(1-)-O]hydroxydioxomolybdenum; hydrogen trioxooxalatomolybdate(VI)
Percent Composition: C 10.27...
Literature References: Usually contains 1 or 2 H2O.

Zinc Oleate CAS Registry Number: 557-07-3 (Z)-9-十八烯酸锌盐

CAS Name: 9-Octadecenoic acid zinc salt
Percent Composition: C 68.82%, H 10.59%, O 10.19%, Zn 10.41%
Literature References: Usually contains small amounts of the zinc salts of other fatty acids. Prepn: Grabner, Monatsh. Chem. 42, 287 (1921).

Sodium Arsphenamine CAS Registry Number: 1936-28-3 4,4'-(1,2-偶胂二基)二(2-氨基苯酚)二钠盐

CAS Name: 4,4'-(1,2-Diarsenediyl)bis[2-aminophenol] disodium salt
Additional Names: 4,4'-arsenobis[2-aminophenol] disodium salt; arsphenamine sodium
Percent Composition: C 35.15%, H 2.46%, A...
Literature References: Usually contains some water and inert salts (NaCl) and hence only about 20% arsenic (As).

Ammonium Uranium Fluoride CAS Registry Number: 18433-40-4

CAS Name: Triammonium pentafluorodioxouranate
Additional Names: ammonium dioxopentafluorouranate(VI); uranium ammonium fluoride; uranyl ammonium fluoride
Percent Composition: F 22.66%, H 2.8...
Literature References: Usually contains some water of crystallization. Prepn and crystal structure: Nguyen-Quy-Dao, Bull. Soc. Chim. Fr. 1968, 3543; idem, Acta Crystallogr. 25B, 67 (1969).

Vanadyl Dichloride CAS Registry Number: 10213-09-9 二氯氧钒

Additional Names: Vanadium oxydichloride
Percent Composition: Cl 51.44%, O 11.61%, V 36.95%
Literature References: Usually contains some water. Prepd according to the eq V2O5 + 3VCl3 + VOCl3 ® 6VOCl2: Funk, Weiss, Z. Anorg. Allg. Chem. 295, 327 (1958); Oppermann, ibid. 351, 113 (1967).

Salicylanilide CAS Registry Number: 87-17-2 水杨酰苯胺

CAS Name: 2-Hydroxy-N-phenylbenzamide
Additional Names: N-phenylsalicylamide
Trademarks: Salinidol (Doak)
Percent Composition: C 73.23%, H 5.20%, N 6.57%, O 15.01%
Literature References: Usually made by the reaction of salicylic acid with aniline in the presence of PCl3 at an elevated temp. Better yields are obtained by using an inert organic solvent such as toluene or carbon tetrachloride as a reaction diluent. Novel process using ion-exchange resins: Majewski, Skelly, US 3221051 (1965). Alternate process: Majewski et al., US 3231611 (1966 to Dow).

Salicin CAS Registry Number: 138-52-3 D-(-)-水杨苷; D-(-)-水杨甙

CAS Name: 2-(Hydroxymethyl)phenyl-b-D-glucopyranoside
Additional Names: salicoside; salicyl alcohol glucoside; saligenin-b-D-glucopyranoside
Percent Composition: C 54.54%, H 6.34%, O 39.12%
Literature References: Usually obtained by making hot water extracts from the ground bark of poplar (Populus) and willow (Salix); also found in the leaves and female flowers of the willow. Isoln from root bark of Viburnum prunifolium L., Caprifoliaceae: Evans et al., J. Am. Pharm. Assoc. 34, 207 (1945). Structure and synthesis: Irvine, Rose, J. Chem. Soc. 89, 814 (1906); Kunz, J. Am. Chem. Soc. 48, 262 (1926). Hydrolysis by acids: Moelwyn-Hughes, Trans. Faraday Soc. 25, 503 (1929). Enzymatic hydrolysis: Pigman, J. Res. Natl. Bur. Stand. 27, 6 (1941). Enzymatic hydrolysis in heavy water: Stacie, Z. Phys. Chem. 28B, 236 (1935).

Metanilic Acid CAS Registry Number: 121-47-1 3-氨基苯磺酸

CAS Name: 3-Aminobenzenesulfonic acid
Additional Names: m-sulfanilic acid; aniline-m-sulfonic acid
Percent Composition: C 41.61%, H 4.07%, N 8.09%, O 27.71%, S 18.51%
Literature References: Usually obtained by reduction of 3-nitrobenzenesulfonic acid: Fierz-David, Blangey, Fundamental Processes of Dye Chemistry (Interscience, New York, 1949) pp 120-123; A. I. Vogel, Practical Organic Chemistry (Longmans, London, 3rd ed., 1959) p 589. Large-scale process: FIAT Final Rept. 1313 (I), 187-191 (1948). The industrial reduction with iron filings and dil acid gives up to 90% yields, in the lab it seldom exceeds 55%. Better yields with small amounts are claimed for a hydrazine-Raney nickel reduction (about 75%): Gialdi et al., Farmaco Ed. Sci. 14, 765 (1959) or by using WS2 (about 94%): Ehrmann, FR 1336648 (1963 to BASF), C.A. 60, 2846d (1964).

Zinc Stearate CAS Registry Number: 557-05-1 硬脂酸锌

CAS Name: Octadecanoic acid zinc salt
Percent Composition: C 68.38%, H 11.16%, O 10.12%, Zn 10.34%
Literature References: Usually occurs as a mixture of the zinc salts of stearic and palmitic acids, and usually with some excess of zinc oxide. Contains 13.5-15% ZnO. Prepd from stearic acid and zinc chloride: Vold, Hattiangdi, Ind. Eng. Chem. 41, 2311 (1949).