其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Glycocholic Acid CAS Registry Number: 475-31-0 甘氨胆酸

CAS Name: N-[(3a,5b,7a,12a)-3,7,12-trihydroxy-24-oxocholan-24-yl]glycine
Additional Names: N-cholylglycine
Percent Composition: C 67.07%, H 9.31%, N 3.01%, O 20.62%
Literature References: The product of conjugation of cholic acid with glycine; chief ingredient of the bile of herbivorous animals. In the weakly alkaline bile fluid glycocholic acid exists as the sodium salt. Prepn from bile: Hammarsten in Abderhalden's Handbuch der Biol. Arbeitsmethoden, Abt. I, Teil 6, p 211 (1925). Prepn from cholic acid: Cortese, J. Am. Chem. Soc. 59, 2532 (1937). Synthesis: Cortese, Bauman, ibid. 57, 1393 (1935); Bergstrom, Norman, Acta Chem. Scand. 7, 1126 (1953). Separation: Antonides, GB 928635 (1963 to Armour). Metabolism: Norman, Scand. J. Gastroenterol. 5, 231 (1970).

Taurocholic Acid CAS Registry Number: 81-24-3 牛磺胆酸

CAS Name: 2-[[(3a,5b,7a,12a)-3,7,12-Trihydroxy-24-oxocholan-24-yl]amino]ethanesulfonic acid
Additional Names: N-choloyltaurine; cholaic acid; cholyltaurine
Percent Composition: C 60.55%, H 8...
Literature References: The product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous animals. Prepn from dog bile: Hammarsten in Abderhalden, Handbuch der Biol. Arbeitsmethoden, Abt. I, Teil 6, p 219 (1925). Separation from bile acids: Ahrens, Craig, J. Biol. Chem. 195, 763 (1952). Enzymic synthesis: Siperstein, Murray, Science 123, 377 (1956). Prepn of the sodium salt: Cortese, J. Am. Chem. Soc. 59, 2532 (1937); Norman, Ark. Kemi 8, 331 (1955); of the barium salt: Kazuno, Yanazaki, Z. Physiol. Chem. 224 160 (1934). Binding of taurocholic acid to serum proteins: Burke et al., Clin. Chim. Acta 32, 207 (1971). Toxicity data: Klaassen, Toxicol. Appl. Pharmacol. 24, 37 (1973).

Flavine-Adenine Dinucleotide CAS Registry Number: 146-14-5 黄素腺嘌呤二核苷酸

CAS Name: Riboflavine 5'-(trihydrogen diphosphate) 5'®5'-ester with adenosine
Additional Names: adenosine 5'-(trihydrogen diphosphate) 5'®5'-ester with riboflavine; FAD; riboflavine 5'-adenosin...
Literature References: The prosthetic group of certain flavoproteins including D-amino acid oxidase, glucose oxidase, glycine oxidase, fumaric hydrogenase, histaminase, and xanthine oxidase. Isoln from yeast: Warburg et al., Biochem. Z. 297, 417 (1938). Structure and isoln from liver, kidneys, hearts, muscles: Warburg, Christian, ibid. 298, 150 (1938); isoln from the mycelium of Eremothecium ashbyii: Yagi, Tada, Biochem. Prep. 7, 51 (1959); Masuda et al., US 2973305 (1961 to Takeda). Synthesis: Christie et al., J. Chem. Soc. 1954, 46; Huennekens, Kilgour, J. Am. Chem. Soc. 77, 6716 (1955); DeLuca, Kaplan, J. Biol. Chem. 223, 569 (1956); Moffatt, Khorana, J. Am. Chem. Soc. 80, 3756 (1958). Review: A. Holmgren, Experientia 36 (Suppl), 149-180 (1980). Review of FAD and other flavin coenzymes: Beinert, The Enzymes vol. 2, P. D. Boyer et al., Eds. (Academic Press, New York, 2nd ed., 1960) pp 339-416; see also vol. XIII Part B (Academic Press, New York, 3rd ed., 1975), several authors.

Echinochrome A CAS Registry Number: 517-82-8 1,4-萘二酚,2-乙基-3,5,6,7,8-戊羟基-

CAS Name: 2-Ethyl-3,5,6,7,8-pentahydroxy-1,4-naphthalenedione
Additional Names: 2-ethyl-3,5,6,7,8-pentahydroxy-1,4-naphthoquinone
Percent Composition: C 54.14%, H 3.79%, O 42.07%
Literature References: The red pigment of the eggs of the sea urchin (Arbacia pustulosa). Isoln and structure: Kuhn, Wallenfels, Ber. 72, 1407 (1939). Synthesis from 2-ethyl-1,3,4-trimethoxybenzene and dibenzoyloxymaleic anhydride: Wallenfels, Gauhe, Ber. 76, 325 (1943).

Dehydroascorbic Acid CAS Registry Number: 490-83-5 (L)-脱氢抗坏血酸++

CAS Name: L-threo-2,3-Hexodiulosonic acid g-lactone
Percent Composition: C 41.39%, H 3.47%, O 55.14%
Literature References: The reversibly oxidized form of ascorbic acid. Prepd by the action of benzoquinone on ascorbic acid: Ohle, Erlbach, Ber. 67, 555 (1934); Moll, Wieters, E. Merck's Jahresber. 50, 65 (1936); by the action of iodine: Herbert et al., J. Chem. Soc. 1933, 1270; Kenyon, Munro, ibid. 1948, 158; by oxidn with peri-naphthindan-2,3,4-trione hydrate: Moubasher, J. Biol. Chem. 176, 533 (1948); see also Müller-Mulot, Z. Physiol. Chem. 351, 52 (1970). Isomerization and formn of derivs: Egge, Tetrahedron Lett. 1969, 801. Structure studies: Teichmann, Ziebarth, Z. Prakt. Chem. 33, 124 (1966). Toxicity studies: Gaudiano et al., Boll. Soc. Ital. Biol. Sper. 43, 674 (1967).

Parasorbic Acid CAS Registry Number: 10048-32-5 (S)-6-甲基-5,6-二氢-2H-吡喃-2-酮

CAS Name: (6S)-5,6-Dihydro-6-methyl-2H-pyran-2-one
Additional Names: 5-hydroxy-2-hexenoic acid lactone; d-Da,b-hexenolactone; 2-hexen-5,1-olide; sorbic oil
Percent Composition: C 64.27%, H 7...
Literature References: The sole constituent of "Vogelbeeröl", an oil obtained by steam distillation of the acidified juice of the ripe berries of the mountain ash, Sorbus aucuparia L., Rosaceae: Hofmann, Ann. 110, 129 (1859); Doebner, Ber. 27, 344 (1894); Kuhn, Jerchel, Ber. 76, 413 (1943). Structure: eidem, ibid. Synthesis: Haynes, Jones, J. Chem. Soc. 1946, 954; Lamberti et al., Recl. Trav. Chim. Pays-Bas 86, 504 (1967). Pharmacology and acute toxicity: H. J. Meyer, R. Kretzschmar, Arzneim.-Forsch. 19, 617 (1969).

Isoamyl Acetate CAS Registry Number: 123-92-2 乙酸异戊酯

Additional Names: Amylacetic ester
Percent Composition: C 64.58%, H 10.84%, O 24.58%
Literature References: The technical product is also known as pear oil or banana oil.

Pederin CAS Registry Number: 27973-72-4 隐翅虫毒素

CAS Name: (1S)-2,6-Anhydro-3,5,7-trideoxy-1-C-[[(2S)-hydroxy[(2R,5R,6R)-tetrahydro-2-methoxy-5,6-dimethyl-4-methylene-2H-pyran-2-yl]acetyl]amino]-5,5-dimethyl-1,8,9-tri-O-methyl-D-manno-nonitol Literature References: The toxic principle isolated from blister beetles, Paederus fuscipes Curt.: Pavan, Bo, Physiol. Comp. Oecol. 3, 307 (1953), C.A. 48, 10217g (1954); GB 932875 (1963 to Farmitalia). Powerful inhibitor of protein biosynthesis and mitosis. Structure: Cardani et al., Gazz. Chim. Ital. 96, 3 (1966). Revised structure: Matsumoto et al., Tetrahedron Lett. 1968, 6297. Biosynthesis: Cardani et al., ibid. 1973, 2815. Total synthesis: F. Matsuda et al., Tetrahedron Lett. 23, 4043 (1982); 24, 1277 (1983).

Cinnamyl Alcohol CAS Registry Number: 104-54-1 肉桂醇; beta-苯丙烯醇

CAS Name: 3-Phenyl-2-propen-1-ol
Additional Names: cinnamic alcohol; styryl carbinol; g-phenylallyl alcohol
Percent Composition: C 80.56%, H 7.51%, O 11.92%
Literature References: The trans-form occurs (in the esterified form) in storax and in balsam Peru, cinnamon leaves, hyacinth oil. Obtained by the alkaline hydrolysis of storax. Prepd synthetically by reducing cinnamal diacetate with iron filings and acetic acid; from cinnamaldehyde by Meerwein-Ponndorf reduction with aluminum isopropoxide: Meerwein, Schmidt, Ann. 444, 221 (1925). Review of risk assessment as fragrance ingredient: D. Bickers et al., Food Chem. Toxicol. 43, 799-836 (2005); of toxicology: C. S. Letizia et al., ibid. 837-866.

Acid Fuchsin CAS Registry Number: 3244-88-0 酸性品红钠盐

CAS Name: 2-Amino-5-[(4-amino-3-sulfophenyl)(4-imino-3-sulfo-2,5-cyclohexadien-1-ylidene)methyl]-3-methylbenzenesulfonic acid disodium salt
Additional Names: C.I. Acid Violet 19; 2-amino-a5-(4-...
Literature References: The trisulfonated derivative of rosanilin, or pararosanilin. See: Colour Index vol. 4 (3rd ed., 1971) p 4399. Use as stain: P. W. Benoit, Stain Technol. 48, 177 (1973); E. Hals, Scand. J. Dent. Res. 85, 542 (1977). Mechanism of action: L. F. Nielsen et al., Biotech. Histochem. 73, 71(1998). Brief review: H. J. Conn's Biological Stains, R. D. Lillie, Ed. (Williams Wilkins, Baltimore, 9th ed., 1977) pp 285-286.