Properties: Clusters of slender, four-sided prisms from alcohol + ether, stable to air. (Commercial prepns are usually amorphous, very hygroscopic, and of yellow color.) Dec about 125°. [a]D18 +38.8° (c = 2 in alcohol). pK 1.4. Freely sol in water, sol in alcohol. Almost insol in ether, ethyl acetate. Is hydrolyzed to cholic acid and taurine by acids and alkalies. LD50 in newborn rats: 380 mg/kg (Klaassen).
pKa: pK 1.4
Optical Rotation: [a]D18 +38.8° (c = 2 in alcohol)
Toxicity data: LD50 in newborn rats: 380 mg/kg (Klaassen)
Derivative Type: Sodium salt
Additional Names: Sodium taurocholate
Percent Composition: C 58.08%, H 8.25%, N 2.61%, Na 4.28%, O 20.83%, S 5.96%
Properties: Crystals with 1.5 and 2 mols H2O. Sweet taste with bitter aftertaste. Dec about 230°. [a]D20 +24° (c = 3). Very freely sol in water or alcohol. Solvent action on cholesterol: Rosin, Z. Physiol. Chem.
124, 282 (1923).
Optical Rotation: [a]D20 +24° (c = 3)
Derivative Type: Barium salt
Additional Names: Barium taurocholate
Percent Composition: C 53.53%, H 7.60%, Ba 11.77%, N 2.40%, O 19.20%, S 5.50%
Properties: Crystals with 5 mols H2O, dec 225-227°. [a]D20 +25.6°. Converted to taurocholic acid by treatment with sulfuric acid.
Optical Rotation: [a]D20 +25.6°
Use: Sodium salt is a lipase accelerator. See also Ox Bile Extract.
Therap-Cat: Choleretic.
Keywords: Choleretic.
产品链接: 81-24-3››