其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
备注: 根据相关法律法规, 本站点不显示有法律约束管制的产品, 如有遗漏, 请自行鉴别,或提交我们及时更新撤除.
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

其它产品项目整合

Amygdalin CAS Registry Number: 29883-15-6 扁桃苷; 苦杏仁甙

CAS Name: [(6-O-b-D-Glucopyranosyl-b-D-glucopyranosyl)oxy]benzeneacetonitrile
Additional Names: amygdaloside; mandelonitrile-b-gentiobioside; D-mandelonitrile-b-D-glucosido-6-b-D-glucosidePerce...
Literature References: The name amygdalin is currently used interchangeably with laetrile. Cyanogenic glycoside which occurs in seeds of Rosaceae; principally in bitter almonds; also in peaches and apricots. Most common constituent of Laetrile® preparations. Structure and synthesis: W. N. Haworth, B. Wylam, J. Chem. Soc. 123, 3120 (1923); Kuhn, Ber. 56, 857 (1923); R. Campbell, W. N. Haworth, J. Chem. Soc. 125, 1337 (1924); Hudson, J. Am. Chem. Soc. 46, 483 (1924); Zemplén, Kunz, Ber. 57, 1357 (1924); Kuhn, Sobotka, ibid. 1767; Baumann, Pigman, The Carbohydrates, W. Pigman, Ed. (Academic Press, New York, 1957) p 550. Enzymic hydrolysis studies: Haisman, Knight, Biochem. J. 103, 528 (1967). The term Laetrile® has also been applied to mandelonitrile b-glucuronide. Purported prepn: E. T. Krebs, E. T. Krebs, Jr., GB 788855 (1958) and US 2985664 (1961). Synthesis, characterization and comparison of mandelonitrile b-glucuronide with amygdalin: C. Fenselau et al., Science 198, 625 (1977). Pharmacology and cyanide toxicity studies of amygdalin (laetrile): C. G. Moertel et al., J. Am. Med. Assoc. 245, 591 (1981); M. M. Ames et al., Cancer Chemother. Pharmacol. 6, 51 (1981). Pharmacokinetics: A. G. Rauws et al., Arch. Toxicol. 49, 311 (1982). Determn methods in tissues and fluids: J. Balkon, J. Anal. Toxicol. 6, 244 (1982). Amygdalin (laetrile) is a toxic drug that is not effective as a cancer treatment: C. G. Moertel et al., N. Engl. J. Med. 306, 201 (1982). Review of the controversial use of amygdalin (laetrile): V. Herbert, Am. J. Clin. Nutr. 32, 1121-1158 (1979).

b -Farnesene CAS Registry Number: 18794-84-8 (E)-β-金合欢烯

CAS Name: 7,11-Dimethyl-3-methylene-1,6,10-dodecatriene
Percent Composition: C 88.16%, H 11.84%
Literature References: The naturally occurring trans form or (E)-isomer is a constituent of various essential oils, see F. Sorm et al., Collect. Czech. Chem. Commun. 14, 699 (1949); 15, 626 (1951); also an alarm pheromone of several aphid species: Bowers et al., Science 177, 1121 (1972); Edwards et al., Nature 241, 126 (1973); W. S. Bowers et al., J. Insect Physiol. 23, 697 (1977). Isoln from leaves of wild potato, Solanum berthaultii Hawkes, Solanaceae: R. W. Gibson, J. A. Pickett, Nature 302, 608 (1983). Prepd by dehydration of farnesol: Bhati, Perfum. Essent. Oil Rec. 54, 376 (1963); Brieger, J. Org. Chem. 32, 3720 (1967); alternate syntheses: Tanaka et al., J. Am. Chem. Soc. 97, 3252 (1975); S. Akutagawa et al., Chem. Lett. 1976, 485; O. P. Vig et al., Indian J. Chem. Sect. B 18, 33 (1979). Synthesis of (Z)-isomer: Anet, Aust. J. Chem. 23, 2101 (1970); O. P. Vig et al., J. Indian Chem. Soc. 47, 999 (1970); eidem, Indian J. Chem. 13, 1244 (1975).

Piperazine Adipate CAS Registry Number: 142-88-1 己二酸哌嗪

CAS Name: Hexanedioic acid compd with piperazine (1:1)
Trademarks: Entacyl (BDH); Oxyzin (tabl.); Vermicompren (tabl.) (Merck KGaA); Nometan; Oxypaat (Katwijk); Pipadox (Dagra); Oxurasin
Per...
Literature References: The neutral salt of piperazine and adipic acid: Davies et al., J. Pharm. Pharmacol. 6, 707 (1954). Prepn in methanolic medium: Forrest, Petrow, US 2799617 (1957 to British Drug Houses); GB 767826. Pharmacology: B. G. Cross et al., J. Pharm. Pharmacol. 6, 711 (1954).

Heparamine CAS Registry Number: 53260-52-9

Additional Names: N-Desulfoheparin
Literature References: The -NHSO3H groups in heparin are replaced by -NH2 groups. Prepn of sodium salt by methanolysis of sodium heparinate and saponification: Velluz et al., Compt. Rend. 247, 1521 (1958); from sodium heparinate heated with HCl, neutralized with NaHCO3 and dialyzed against running water: Foster et al., J. Chem. Soc. 1961, 1204; from sodium heparinate demineralized with Dowex 50 resin: GB 863235 (1961 to UCLAF).

Calcium D -Saccharate CAS Registry Number: 5793-88-4 葡萄糖二酸

CAS Name: D-Glucaric acid calcium salt
Percent Composition: C 29.03%, H 3.25%, Ca 16.15%, O 51.57%
Literature References: The normal calcium salt of D-saccharic acid, a dicarboxylic sugar acid derived from the oxidation of D-gluconic acid. Calcium D-saccharate is a true chemical compd and should not be confused with saccharated lime, formerly called "calcium saccharate" and produced by the action of lime upon sugar. Prepn: Beilstein vol. 3, 2nd suppl., 378; Hagers Handb. Pharm. Praxis vol. 1, 755 (Berlin, 1930).

Enanthotoxin CAS Registry Number: 20311-78-8 水芹毒素

CAS Name: (2E,8E,10E)-2,8,10-Heptadecatriene-4,6-diyne-1,14-diol
Additional Names: oenanthotoxin
Percent Composition: C 79.03%, H 8.58%, O 12.39%
Literature References: The poisonous principle of Oenanthe crocata L., Umbelliferae, the hemlock water dropwort, a toxic plant known since 1746 and believed to be the most poisonous plant in England. Isoln: Clarke et al., J. Pharm. Pharmacol. 1, 377 (1949). Structure studies: Anet et al., Chem. Ind. (London) 1952, 757; J. Chem. Soc. 1953, 309. Synthesis of DL-form: Bohlmann, Viehe, Ber. 88, 1245 (1955). Fluorimetric determn: B. Del Castillo et al., Ital. J. Biochem. 29, 233 (1980). Blocking of sodium current and intramembrane charge movement: J. M. Dubois, M. F. Schneider, Nature 289, 685 (1981); eidem, Toxicon 20, 49 (1982). Toxicity study: M. P. Martinez-Honduvilla et al., Arch. Farmacol. Toxicol. 7, 197 (1981).

a -Bromobenzyl Cyanide CAS Registry Number: 5798-79-8 2-溴-2-苯基乙腈

CAS Name: a-Bromobenzeneacetonitrile
Additional Names: a-bromophenylacetonitrile; a-bromo-a-tolunitrile; B.B.C.; C.A.
Trademarks: Camite
Percent Composition: C 49.01%, H 3.08%, Br 40.76%,...
Literature References: The practical industrial prepn consists of three steps: (1) Chlorination of toluene to form benzyl chloride, (2) conversion of benzyl chloride to benzyl cyanide by the action of sodium cyanide in alcoholic soln, (3) bromination of the benzyl cyanide with bromine vapor in the presence of sunlight: Steinkopf et al., Ber. 53, 1146 (1920); Nekrassov, J. Prakt. Chem. 119, 108 (1928).

Gentiopicrin CAS Registry Number: 20831-76-9 龙胆苦苷

CAS Name: (5R-trans)-5-Ethenyl-6-(b-D-glucopyranosyloxy)-5,6-dihydro-1H,3H-pyrano[3,4-c]pyran-1-one
Additional Names: gentiopicroside
Percent Composition: C 53.93%, H 5.66%, O 40.41%
Literature References: The principal bitter glucoside of common gentians, which was isolated in 1862 from Gentiana lutea, L., Gentianaceae: Canonica et al., Tetrahedron 16, 192 (1961). Isoln from roots of G. lutea: Korte, Ber. 87, 512 (1954); Korte et al., ibid. 91, 759 (1958). Structure: Canonica et al., Tetrahedron Lett. 1960(24), 7; Tetrahedron 16, 192 (1961). Revised structure: Inouye et al., Tetrahedron Lett. 1968, 4429. Absolute configuration: Manitto, Pagnoni, Gazz. Chim. Ital. 94, 229 (1964).

Calcifediol CAS Registry Number: 19356-17-3 骨化二醇

CAS Name: (3b,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-3,25-diol
Additional Names: 25-hydroxyvitamin D3; 25-hydroxycholecalciferol; 25-HCCTrademarks: Dedrogyl (DESMA); Didrogyl (Bruno); Hidro...
Literature References: The principal circulating form of vitamin D3, formed in the liver by hydroxylation at C-25: Ponchon, DeLuca, J. Clin. Invest. 48, 1273 (1969). It is the intermediate in the formation of 1a,25-dihydroxycholecalciferol, q.v., the biologically active form of vitamin D3 in the intestine. Identification in rat as an active metabolite of vitamin D3: Lund, DeLuca, J. Lipid Res. 7, 739 (1966); Morii et al., Arch. Biochem. Biophys. 120, 513 (1967). Evaluation of biological activity in comparison with vitamin D3: Blunt et al., Proc. Natl. Acad. Sci. USA 61, 717 (1968); ibid. 1503. Isoln from porcine plasma and establishment of structure: Blunt et al., Biochemistry 7, 3317 (1968). Synthesis: Blunt, DeLuca, ibid. 8, 671 (1969). Review of isoln, identification and synthesis: DeLuca, Am. J. Clin. Nutr. 22, 412 (1969). Review of bioassays: J. G. Haddad Jr., Basic Clin. Nutr. 2, 579-597 (1980).

Troxerutin CAS Registry Number: 7085-55-4 曲克芦丁

CAS Name: 2-[3,4-Bis(2-hydroxyethoxy)phenyl]-3-[[6-O-(6-deoxy-a-L-mannopyranosyl)-b-D-glucopyranosyl]oxy]-5-hydroxy-7-(2-hydroxyethoxy)-4H-1-benzopyran-4-one
Additional Names: 7,3',4'-tris[O-(2...
Literature References: The principal component of a mixture, the O-(b-hydroxyethyl)rutosides, which also contains mono-, di-, tetra- and other trihydroxyethyl derivs of rutin, q.v. The mixture is prepd by the hydroxyethylation of the phenolic groups of rutin with glycochlorohydrin in alk medium: J. Favre, CH 349614 (1957); see also GB 833174 (1960 to Zyma), C.A. 54, 21135i (1960). Isolation and identification of major components of the mixture: P. Courbat et al., Helv. Chim. Acta 49, 1203, 1420 (1966). Prepn of troxerutin: P. J. Courbat, US 3420815 (1969 to Zyma). Metabolism in man: A. M. Hackett et al., Arzneim.-Forsch. 26, 925 (1976).