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Enanthotoxin CAS Registry Number: 20311-78-8 水芹毒素

CAS Name: (2E,8E,10E)-2,8,10-Heptadecatriene-4,6-diyne-1,14-diol
Additional Names: oenanthotoxin
Percent Composition: C 79.03%, H 8.58%, O 12.39%

📌 参考资料/链接：
Literature References: The poisonous principle of Oenanthe crocata L., Umbelliferae, the hemlock water dropwort, a toxic plant known since 1746 and believed to be the most poisonous plant in England. Isoln: Clarke et al., J. Pharm. Pharmacol. 1, 377 (1949). Structure studies: Anet et al., Chem. Ind. (London) 1952, 757; J. Chem. Soc. 1953, 309. Synthesis of DL-form: Bohlmann, Viehe, Ber. 88, 1245 (1955). Fluorimetric determn: B. Del Castillo et al., Ital. J. Biochem. 29, 233 (1980). Blocking of sodium current and intramembrane charge movement: J. M. Dubois, M. F. Schneider, Nature 289, 685 (1981); eidem, Toxicon 20, 49 (1982). Toxicity study: M. P. Martinez-Honduvilla et al., Arch. Farmacol. Toxicol. 7, 197 (1981).

📄 详细内容

Properties: Large prisms (natural) or star-shaped crystals (synthetic). Unstable, dec by light and air to brown insol resin. mp 87° (natural), 68° (synthetic). [a]D15 +30.5° (c = 2.0 in methanol). uv max: 213, 252, 267, 281, 296, 315.5, 337.5 (e ´ 10-3 17.5, 33, 29, 17.5, 30.5, 40, 29). Practically insol in water, petr ether, alkalies, dil mineral acids. Readily sol in chloroform, ethanol, methanol, ether, benzene. Average LD i.p. in mice: 0.83 mg/kg (Clarke). LD50 i.p. in rats: 2.94 mg/kg (Martinez-Honduvilla).
Melting point: mp 87° (natural), 68° (synthetic)
Optical Rotation: [a]D15 +30.5° (c = 2.0 in methanol)
Absorption maximum: uv max: 213, 252, 267, 281, 296, 315.5, 337.5 (e ´ 10-3 17.5, 33, 29, 17.5, 30.5, 40, 29)
Toxicity data: Average LD i.p. in mice: 0.83 mg/kg (Clarke); LD50 i.p. in rats: 2.94 mg/kg (Martinez-Honduvilla)
CAUTION: Very toxic. May cause convulsions, death.
产品链接: 20311-78-8››

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