CAS: 20311-78-8; (R,2E,8E,10E)-Heptadeca-2,8,10-Trien-4,6-Diyne-1,14-Diol

上下游产品

(2E,8E,10E,14R)-1-O-Acetyl-2,8,10-Heptadecatrien-4,6-Diyne-1,14-Diol
(7E,9E,15E)-17-Hydroxy-7,9,15-Heptadecatrien-11,13-Diyn-4-One 20311-75-5

📜6-Methoxy-3,6-Dihydro-2H-Pyran置于吡啶,N-溴代丁二酰亚胺(Nbs),Copper(L) Iodide,Lithium Aluminium Tetrahydride,磷酸,水,三溴化磷,Sodium Hydride,N,N-二异丙基乙胺,Lithium Chloride,Sodium Hydroxide体系中,用 四氢呋喃,乙醚,异丙醚,水,乙腈 用作溶剂,化学反应 48.0H,反应生成水芹毒素
参考文献:Chemoenzymatic Synthesis And Cytotoxicity Of Oenanthotoxin And Analogues
标题:Chemoenzymatic Synthesis And Cytotoxicity Of Oenanthotoxin And Analogues
摘要:We Developed A Synthetic Scheme For The Synthesis Of Naturally occurring (14R)-Oenanthotoxin And Several Analogs. Key-Steps Of This Synthesis Were An Efficient Homo-Coupling Of Alkynes And A Chemoenzymatic Resolution Of Racemic Oenanthotoxin Using Novozyme 435 And Vinyl Acetate. The Compounds Were Screened For Their Cytotoxic Activity Using A Photometric Sulforhodamine B Assays And Several Human Tumor Cell Lines. Oenanthotoxin And Many Derivatives Thereof Were Cytotoxic To Tumor Cell Lines As Well As To Non-Malignant Mouse Fibroblasts. The Highest Activity Was Determined For Human Ovarian Cancer Cells A2780 With Ec50 = 3.8 Mu M. (C) 2015 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmc.2015.07.031