其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
备注: 根据相关法律法规, 本站点不显示有法律约束管制的产品, 如有遗漏, 请自行鉴别,或提交我们及时更新撤除.
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

其它产品项目整合

Corydaldine CAS Registry Number: 493-49-2 6,7-二甲氧基-3,4-二氢-异喹啉-1-酮

CAS Name: 3,4-Dihydro-6,7-dimethoxy-1(2H)-isoquinolinone
Additional Names: 3,4-dihydro-6,7-dimethoxyisocarbostyril; 1,2,3,4-tetrahydro-6,7-dimethoxy-1(2H)-1-isoquinolone
Percent Composition:...
Literature References: Synthesis: Späth, Dobrowsky, Ber. 58, 1274 (1925); Mohunta, Ray, J. Chem. Soc. 1934, 1263; Wiesner et al., J. Am. Chem. Soc. 77, 675 (1955); Brossi et al., Helv. Chim. Acta 43, 1459 (1960); Mahuzier, Hamon, Bull. Soc. Chim. Fr. 1969, 684.

Pheniramine CAS Registry Number: 86-21-5 非尼拉敏

CAS Name: N,N-Dimethyl-g-phenyl-2-pyridinepropanamine
Additional Names: 2-[a-(2-dimethylaminoethyl)benzyl]pyridine; 1-phenyl-1-(2-pyridyl)-3-dimethylaminopropane; 3-phenyl-3-(2-pyridyl)-N,N-dim...
Literature References: Synthesis: Sperber et al., US 2567245 and US 2676964 (1951, 1954, both to Schering).

Chlorpheniramine CAS Registry Number: 132-22-9

CAS Name: g-(4-Chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine
Additional Names: 2-[p-chloro-a-(2-dimethylaminoethyl)benzyl]pyridine; 1-(p-chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane; 1...
Literature References: Synthesis: Sperber et al., US 2567245, US 2676964 (1951, 1954, both to Schering). Prepn of d-form: L. A. Walter, US 3061517 (1962 to Schering). Solutions: Foley, Ilavsky, US 2766174 (1956 to Schering). Pharmacology: F. E. Roth, W. M. Govier, J. Pharmacol. Exp. Ther. 124, 347 (1958). Toxicity data: R. B. Smith et al., Toxicol. Appl. Pharmacol. 28, 240 (1974). Comprehensive description: C. G. Eckhart, T. McCorkle, Anal. Profiles Drug Subs. 7, 43-80 (1978).

Trimethadione CAS Registry Number: 127-48-0 3,5,5,-三甲基恶唑烷-2,4-二酮

CAS Name: 3,5,5-Trimethyl-2,4-oxazolidinedione
Additional Names: 3,5,5-trimethyl-2,4-dioxooxazolidine; troxidone
Trademarks: Absentol (Nourypharma); Epidione (Bellon); Petidon; Ptimal (Egis)...
Literature References: Synthesis: Spielman, J. Am. Chem. Soc. 66, 1244 (1944); US 2575692 (1951 to Abbott); Davies, Hook, US 2559011 (1951 to Brit. Schering). Metabolism to dimethadione, q.v.: T. C. Butler, J. Pharmacol. Exp. Ther. 108, 11 (1953); T. C. Butler, W. J. Waddell, ibid. 110, 241 (1954). Anticonvulsant activity: H. Ferngren, Acta Pharmacol. Toxicol. 26, 177 (1968); H. H. Frey, ibid. 27, 295 (1969). Pharmacodynamics and metabolism in rats: D. O. Thueson et al., Epilepsia 15, 563 (1974). Evaluation in teratogenesis: J. German et al., Teratology 3, 349 (1970); A. B. Rifkind, Toxicol. Appl. Pharmacol. 30, 452 (1974). GC determn in serum: E. Tanaka, S. Misawa, J. Chromatogr. 413, 376 (1987); LC determn in serum: M. Okamoto et al., Chromatographia 23, 325 (1987). Use in treatment of petit mal epilepsy: S. Livingston et al., J. Am. Med. Assoc. 194, 227 (1965). Use in dissolution of pancreatic stones in humans and dogs: A. Noda et al., Lancet 2, 351 (1984); eidem, Gastroenterology 93, 1002 (1987).

Acetylpheneturide CAS Registry Number: 13402-08-9 N-[(乙酰氨基)羰基]-2-苯基丁酰胺

CAS Name: N-[(Acetylamino)carbonyl]-a-ethylbenzeneacetamide
Additional Names: 1-acetyl-3-(2-phenylbutyryl)urea; N-(a-ethylphenylacetyl)-N'-acetylurea
Trademarks: Crampol (Dainippon)
Perce...
Literature References: Synthesis: Umemoto et al., Yakugaku Zasshi 83, 753 (1963), C.A. 59, 13849d (1963); Takamatsu et al., US 3110728 (1963 to Dainippon). Pharmacology and toxicology: Nakamura et al., Arzneim.-Forsch. 18, 524 (1968).

Twistane CAS Registry Number: 253-14-5

CAS Name: Tricyclo[4.4.0.03.8]decane
Percent Composition: C 88.16%, H 11.84%
Literature References: Synthesis: Whitlock, J. Am. Chem. Soc. 84, 3412 (1962); Gautier, Deslongchamps, Can. J. Chem. 45, 297 (1967); Whitlock, Siefken, J. Am. Chem. Soc. 90, 4929 (1968). Absolute configuration: Keiichi et al., Tetrahedron Lett. 1968, 5467.

Perifosine CAS Registry Number: 157716-52-4 哌立福新

CAS Name: 4-[[Hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethylpiperidinium inner salt
Additional Names: octadecyl-(1,1-dimethylpiperidinio-4-yl)phosphatePercent Composition: C 65.04%, H 11.35%...
Literature References: Synthetic alkylphosphocholine anticancer agent. Inhibits the phosphatidylinositol 3-kinase regulated Akt/PKB survival pathway and induces apoptosis. Prepn: G. Nössner et al., DE 4222910; eidem, US 6172050 (1994, 2001 both to Asta Medica). Mechanism of action study: G. A. Ruiter et al., Anti-Cancer Drugs 14, 167 (2003). LC-ESI-MS determn in plasma: E. W. Woo et al., J. Chromatogr. B 759, 247 (2001). Biodistribution and tumor uptake: S. R. Vink et al., Invest. New Drugs 23, 279 (2005). Clinical pharmacokinetics: M. Crul et al., Eur. J. Cancer 38, 1615 (2002); evalution in advanced cancer: L. Van Ummersen et al., Clin. Cancer Res. 10, 7450 (2004).

Droxidopa CAS Registry Number: 23651-95-8 屈西多巴

CAS Name: threo-b,3-Dihydroxy-L-tyrosine
Additional Names: L-threo-3-(3,4-dihydroxyphenyl)serine; (-)-(2S,3R)-2-amino-3-hydroxy-3-(3,4-dihydroxyphenyl)propionic acid; threo-dopaserine; L-threo-...
Literature References: Synthetic amino acid precursor of norepinephrine, q.v. Prepn of racemate: K. W. Rosenmund, H. Dornsaft, Ber. 52B, 1734 (1919). Separation and resolution of diastereomers: B. Hegedüs et al., Helv. Chim. Acta 58, 147 (1975); B. Hegedüs, A. Krasso, US 3920728 (1975 to Hoffmann-La Roche). Improved process for production: N. Ohashi et al., US 4319040 (1982 to Sumitomo). Pharmacology of stereoisomers: G. Bartholini et al., J. Pharmacol. Exp. Ther. 193, 523 (1975). Clinical pharmacology of L-threo-form and clinical evaluation in familial amyloid polyneuropathy (FAP): T. Suzuki et al., Eur. J. Clin. Pharmacol. 17, 429 (1980). Reversed-phase chromatography determn in plasma and urine: F. Boomsma et al., J. Chromatogr. 427, 219 (1988). Pharmacokinetics in FAP: T. Suzuki et al., Eur. J. Clin. Pharmacol. 23, 463 (1982); in parkinsonism: T. Suzuki et al., Neurology 34, 1446 (1984). Metabolism to norepinephrine: T. Suzuki et al., Life Sci. 36, 435 (1985). Clinical studies in Parkinson's disease: N. Ogawa et al., J. Med. 16, 525 (1985); H. Narabayashi et al., Adv. Neurol. 45, 593 (1986).

Cycloleucine CAS Registry Number: 52-52-8 环亮氨酸

CAS Name: 1-Aminocyclopentanecarboxylic acid
Additional Names: ACPCPercent Composition: C 55.79%, H 8.58%, N 10.84%, O 24.77%
Literature References: Synthetic amino acid thought to act as a valine antagonist. Prepn: Zelinsky, Stadnikoff, Z. Physiol. Chem. 75, 350 (1911); Connors, Ross, J. Chem. Soc. 1960, 2119; Cremlyn, ibid. 1962, 3977; Sudo, Ichihara, Bull. Chem. Soc. Jpn. 36, 34 (1963). Manuf: NL 6607754 (1966 to Rohm Haas), C.A. 67, 73159b (1967). Review: R. B. Ross et al., J. Med. Pharm. Chem. 3, 1 (1961). Immunopharmacology: Rosenthale et al., J. Pharmacol. Exp. Ther. 180, 501 (1972); Brambilla et al., Cancer Chemother. Rep. Part 1 56, 579 (1972).

Bolasterone CAS Registry Number: 1605-89-6 勃拉睾酮

CAS Name: (7a,17b)-17-Hydroxy-7,17-dimethylandrost-4-en-3-one
Additional Names: 7a,17a-dimethyltestosterone
Percent Composition: C 79.70%, H 10.19%, O 10.11%
Literature References: Synthetic anabolic; epimeric with calusterone, q.v. Prepn: BE 610385; Babcock, Campbell, US 3341557 (1962, 1967 both to Upjohn); Campbell, Babcock, Hormonal Steroids, Proc. 1st Int. Congr., 2, L. Martini, A. Pecile, Eds. (Academic Press, New York, 1965) pp 59-67. Activity studies: Stucki et al., ibid. 119-132. HPLC determn in urine: R. Gonzalo-Lumbreras, R. Izquierdo-Hornillos, J. Chromatogr. B 742, 47 (2000).