其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

N-2-Fluorenylacetamide CAS Registry Number: 53-96-3 2-乙酰氨基氟

CAS Name: N-9H-Fluoren-2-ylacetamide
Additional Names: 2-acetylaminofluorene; AAF; 2-FAA
Percent Composition: C 80.69%, H 5.87%, N 6.27%, O 7.17%
Literature References: Synthesis: Hayashi, Nakayama, J. Soc. Chem. Ind. Jpn. [Suppl] 36, 127B (1933). Carcinogenicity studies: R. H. Wilson et al., Cancer Res. 1, 595 (1941). Toxicity studies: Haley et al., Proc. Soc. Exp. Biol. Med. 143, 1117 (1973); 146, 648 (1974).

Iothalamic Acid CAS Registry Number: 2276-90-6 碘他拉酸

CAS Name: 3-(Acetylamino)-2,4,6-triiodo-5-[(methylamino)carbonyl]benzoic acid
Additional Names: 5-acetamido-2,4,6-triiodo-N-methylisophthalamic acid
Percent Composition: C 21.52%, H 1.48%, I...
Literature References: Synthesis: Hoey et al., J. Med. Chem. 6, 24 (1963).

Hydroflumethiazide CAS Registry Number: 135-09-1 氢氟噻嗪

CAS Name: 3,4-Dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Additional Names: 6-trifluoromethyl-3,4-dihydro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide; ...
Literature References: Synthesis: Holdrege et al., J. Am. Chem. Soc. 81, 4807 (1959); Close et al., ibid. 82, 1132 (1960); Yale et al., ibid. 2042; Novello et al., J. Org. Chem. 25, 970 (1960). Numerous patents, e.g., Lund et al., US 3254076 (1966 to Lövens Kemiske Fabrik). Pharmacology: J. J. Piala et al., J. Pharmacol. Exp. Ther. 134, 273 (1961). Comprehensive description: C. E. Orzech et al., Anal. Profiles Drug Subs. 7, 297-317 (1978).

Flumethiazide CAS Registry Number: 148-56-1 氟甲噻嗪

CAS Name: 6-(Trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Additional Names: 6-trifluoromethyl-7-sulfamoyl-4H-1,2,4-benzothiadiazine 1,1-dioxide; 6-trifluoromethyl-7-sulf...
Literature References: Synthesis: Holdrege et al., J. Am. Chem. Soc. 81, 4807 (1959); Yale et al., ibid. 82, 2042 (1960); US 3040042 (1962 to Olin Mathieson); GB 861809 (1961 to SKF).

Dimethindene CAS Registry Number: 5636-83-9 二甲茚定

CAS Name: N,N-Dimethyl-3-[1-(2-pyridinyl)ethyl]-1H-indene-2-ethanamine
Additional Names: 2-[1-[2-[2-(dimethylamino)ethyl]inden-3-yl]ethyl]pyridine; 3-[a-(2'-pyridyl)ethyl]-2-(b-dimethylaminoeth...
Literature References: Synthesis: Huebner et al., J. Am. Chem. Soc. 82, 2077 (1960); Huebner, US 2970149 (1961 to Ciba). Pharmacology: W. E. Barrett et al., Toxicol. Appl. Pharmacol. 3, 534 (1961).

Prosultiamine CAS Registry Number: 59-58-5 丙舒硫胺

CAS Name: N-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-(propyldithio)-1-butenyl]formamide
Additional Names: 2-(2-methyl-4-aminopyrimidin-5-yl)methylformamido-5-hydroxy-2-p...
Literature References: Synthesis: Matsukawa, Kawasuki, J. Pharm. Soc. Jpn. 73, 216 (1953), C.A. 48, 2071 (1954); Matsukawa et al., J. Vitaminol. 1, 13 (1954); Fujiwara et al., US 2833768 (1958 to Takeda), cf. FR 1068459 (1954 to Takeda). Structural studies: Nishikawa et al., Chem. Pharm. Bull. 17, 932 (1969). Metabolism: Suzuoki-Ziro et al., J. Biochem. 58, 279 (1965); Nishikawa et al., J. Pharmacol. Exp. Ther. 157, 589 (1967).

Bufexamac CAS Registry Number: 2438-72-4 丁苯羟酸

CAS Name: 4-Butoxy-N-hydroxybenzeneacetamide
Additional Names: 2-(p-butoxyphenyl)acetohydroxamic acid; 2-[p-(butyloxy)phenyl]acetohydroxamic acidTrademarks: Droxarol (Pharmos); Droxaryl (Contin...
Literature References: Synthesis: N. P. Buu-Hoï et al., Compt. Rend. 261, 2259 (1965); eidem, BE 661226; eidem, US 3479396 (1965, 1969 to Madan). Pharmacology and toxicology: Lambelin et al., Med. Pharmacol. Exp. 15, 545 (1966).

Sulfaphenazole CAS Registry Number: 526-08-9 磺胺苯吡唑

CAS Name: 4-Amino-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide
Additional Names: N'-(1-phenylpyrazol-5-yl)sulfanilamide; 1-phenyl-5-sulfanilamidopyrazole; 3-(p-aminobenzenesulfonamido)-2-phen...
Literature References: Synthesis: Schmidt, Druey, Helv. Chim. Acta 41, 309 (1958); Druey, Schmidt, US 2858309 (1958 to Ciba). Toxicity study: Seki et al., Arzneim.-Forsch. 15, 1441 (1965).

a -Glucogallin CAS Registry Number: 53318-36-8

CAS Name: a-D-Glucopyranose 1-(3,4,5-trihydroxybenzoate)
Additional Names: a-D-glucopyranose-1-gallate; 1-galloyl-a-D-glucose
Percent Composition: C 46.99%, H 4.85%, O 48.15%
Literature References: Synthesis: Schmidt, Herok, Ann. 587, 63 (1954); Schmidt, Schmadel, ibid. 649, 149 (1961).

Pentahomoserine CAS Registry Number: 533-88-0 2-氨基-5-羟基戊酸

CAS Name: 5-Hydroxynorvaline
Additional Names: a-amino-d-hydroxy-n-valeric acid; 2-amino-5-hydroxypentanoic acid
Percent Composition: C 45.10%, H 8.33%, N 10.52%, O 36.05%
Literature References: Synthesis: Sörensen, Bull. Soc. Chim. Fr. 33, 1052 (1904); Plieninger, Ber. 83, 271 (1950); Gaudry, Can. J. Chem. 29, 544 (1951). Enzymatic resolution: Berlinguet, Gaudry, J. Biol. Chem. 198, 765 (1952).