其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Pyridoxamine Dihydrochloride CAS Registry Number: 524-36-7 盐酸吡多胺

CAS Name: 4-(Aminomethyl)-5-hydroxy-6-methyl-3-pyridinemethanol dihydrochloride
Additional Names: 2-methyl-3-hydroxy-4-aminomethyl-5-hydroxymethylpyridine dihydrochloride
Percent Composition...
Literature References: Synthesis and structure: Harris et al., J. Biol. Chem. 154, 315 (1944); J. Am. Chem. Soc. 66, 2088 (1944).

Pyridoxal CAS Registry Number: 66-72-8 3-羟基-5-羟甲基-2-甲基吡啶-4-甲醛

CAS Name: 3-Hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde
Additional Names: 3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde; 2-methyl-3-hydroxy-4-formyl-5-hydroxymethylpyri...
Literature References: Synthesis and structure: Harris et al., J. Biol. Chem. 154, 315 (1944); J. Am. Chem. Soc. 66, 2088 (1944).

Homocystine CAS Registry Number: 462-10-2 L-高胱氨酸

CAS Name: 4,4'-Dithiobis[2-aminobutanoic acid]
Additional Names: 4,4'-dithiobis[2-aminobutyric acid]
Percent Composition: C 35.81%, H 6.01%, N 10.44%, O 23.85%, S 23.90%
Literature References: Synthesis by the "malonate" method: Patterson, du Vigneaud, J. Biol. Chem. 111, 393 (1935); Shiroishi et al., Rep. Food Res. Inst. (Tokyo) 5, 75 (1951); du Vigneaud, Brown, Biochem. Prep. 5, 93 (1957); from 3,6-bis(b-chloroethyl)-2,5-dioxopiperazine: Snyder, Cannon, J. Am. Chem. Soc. 66, 511 (1944).

Tocol CAS Registry Number: 119-98-2 2-甲基-2-(4,8,12-三甲基十三烷基)-6-色满醇

CAS Name: 3,4-Dihydro-2-methyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol
Additional Names: 2-methyl-2-(4,8,12-trimethyltridecyl)-6-chromanol; 2-methyl-2-phytyl-6-chromanol; 6-hydroxy-2-...
Literature References: Synthesis by the condensation of hydroquinone and phytol in the presence of anhydr formic acid: Pendse, Karrer, Helv. Chim. Acta 40, 1837 (1957). Antioxidant activity of tocol and its methyl derivs: Olcott, van der Veen, Lipids 3, 331 (1968).

Cholanthrene CAS Registry Number: 479-23-2 1,2-二氢苯[J]并苊

CAS Name: 1,2-Dihydrobenz[j]aceanthrylene
Percent Composition: C 94.45%, H 5.55%
Literature References: Synthesis from 1-b-naphthylhydrindene: Cook et al., J. Chem. Soc. 1935, 667; from 4-indanyl-MgBr and 1-naphthoyl chloride: Fieser, Seligman, J. Am. Chem. Soc. 57, 2174 (1935).

Coumarilic Acid CAS Registry Number: 496-41-3 苯并[b]呋喃-2-羧酸

CAS Name: 2-Benzofurancarboxylic acid
Additional Names: coumarone-2-carboxylic acid
Percent Composition: C 66.67%, H 3.73%, O 29.60%
Literature References: Synthesis from coumarin: Fuson et al., Org. Synth. coll. vol. III, 209 (1955). Review: Sethna, Shah, Chem. Rev. 36, 1 (1945).

Tryptazan CAS Registry Number: 526-30-7 2-氨基-3-(3-吲唑基)丙酸

CAS Name: a-Amino-1H-indazole-3-propanoic acid
Additional Names: a-amino-1H-indazole-3-propionic acid; 3-indazolealanine
Percent Composition: C 58.53%, H 5.40%, N 20.48%, O 15.59%
Literature References: Synthesis from isatin: Snyder et al., J. Am. Chem. Soc. 74, 2009 (1952).

Phenatine CAS Registry Number: 139-68-4 烟酰苯丙胺

CAS Name: N-(1-Methyl-2-phenylethyl)-3-pyridinecarboxamide
Additional Names: N-(a-methylphenethyl)nicotinamide; nicotinic acid b-phenylisopropylamide; nicotinoyl-b-phenylisopropylamine; fenatin...
Literature References: Synthesis from nicotinoyl chloride and C6H5CH2CH(CH3)NH2: Arbuzov et al., Sb. Statei Obshch. Khim. 1, 714 (1953), C.A. 49, 1072 (1955). Pharmacology: Arbuzov, Farmakol. Toksikol. 31, 373 (1968). Analysis: P. P. Suprun, Farm. Zh. (Kiev) 30, 49 (1975); O. N. Shcherbina et al., ibid. 1979, 49.

Methoxyethylbenzeneboronic Acid CAS Registry Number: 159752-39-3 (R)-(2-(1-甲氧基乙基)苯基)硼酸

CAS Name: [2-[(1R)-1-Methoxyethyl]phenyl]boronic acid
Percent Composition: C 60.05%, H 7.28%, B 6.01%, O 26.66%
Literature References: Synthesis of (+)-form and use: K. Burgess, A. M. Porte, Angew. Chem. Int. Ed. 33, 1182 (1994). Chemoenzymatic stereosynthesis of both enantiomers and use: S. M. Resnick et al., J. Org. Chem. 60, 3546 (1995).

Tretoquinol CAS Registry Number: 21650-42-0 1-[(3,4,5-三甲氧基苯基)甲基]-1,2,3,4-四氢异喹啉-6,7-二醇

CAS Name: 1,2,3,4-Tetrahydro-1-[(3,4,5-trimethoxyphenyl)methyl]-6,7-isoquinolinediol
Additional Names: 1-(3',4',5'-trimethoxybenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline; trimethoquinol...
Literature References: Synthesis of dl-form: Yamato et al., Tetrahedron Suppl. 8, 129 (1966). Pharmacology: Fogelman, Grundy, Br. J. Pharmacol. 38, 416 (1970). Metabolic studies: Meshi et al., Biochem. Pharmacol. 19, 2937 (1970); Satoh et al., Chem. Pharm. Bull. 19, 667 (1971).