其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Helveticoside CAS Registry Number: 630-64-8 灰白糖芥甙

CAS Name: (3b,5b)-[(2,6-Dideoxy-b-D-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide
Additional Names: erisimin; erysimin; alleoside A
Percent Composition: C 65.15%, H 7.92%,...
Literature References: A b-glycoside consisting of one mole strophanthidin and one mole D-digitoxose. Isoln from Erysimum helveticum (Jacq.) DC. and Erysimum crepidifolium Reichenb., Cruciferae, and structure: Nagata et al., Helv. Chim. Acta 40, 41 (1957); eidem, Festschr. Arthur Stoll 1957, 715; Gmelin, DE 1221764 (1966). From Erysimum spp.: Kowalewski, Helv. Chim. Acta 43, 1314 (1960). Toxicity study: Graebner, Giesel, Arzneim.-Forsch. 22, 1854 (1972).

Octopamine CAS Registry Number: 104-14-3 奥克巴胺

CAS Name: a-(Aminomethyl)-4-hydroxybenzenemethanol
Additional Names: a-(aminomethyl)-p-hydroxybenzyl alcohol; 1-(p-hydroxyphenyl)-2-aminoethanol; norsympatol; norsynephrine; p-hydroxyphenyletha...
Literature References: A biogenic amine that is the phenol analog of noradrenaline (norepinephrine, q.v.). It is a neurosecretory product found in several vertebrates and invertebrates. Formed by b-hydroxylation of tyramine by the enzyme dopamine b-hydroxylase: Pisano et al., Biochim. Biophys. Acta 43, 566 (1960). Identification: Erspamer, Nature 169, 375 (1952). Found in the salivary glands of Octopus vulgaris, O. macropus, and of Eledone moschata: idem, Arzneim.-Forsch. 2, 253 (1952); in mammalian nerves: Molinoff, Axelrod, Science 164, 428 (1969); in cockroach nervous system: Nathanson, Greengard, ibid. 180, 308 (1973). Prepd synthetically: Asscher, US 2585988 (1952). The natural D(-) form is 3 times more potent than the L(+) form in producing cardiovascular adrenergic responses in anesthetized dogs and cats: Korol, Soffer, Pharmacologist 5, 247 (1963). Prepn of D- and L-forms: Kappe, Armstrong, J. Med. Chem. 7, 569 (1964). In invertebrate nervous systems octopamine may function as a neurotransmitter: Saavedra et al., Science 185, 364 (1974). Effects on neuromuscular transmission in crustacean muscle: C. A. Breen, H. L. Atwood, Nature 303, 716 (1983).

Anabsinthin CAS Registry Number: 6903-12-4

CAS Name: (3S,3aS,6S,6aR,6bS,7R,7aR,8S,10aS,11S,13aS,13bS,13cR,14bS,15S)-3,3a,4,5,6,6a,6b,7,7a,8,9,10,10a,13a,13c,14b-Hexadecahydro-6-hydroxy-3,6,8,11,14,15-hexamethyl-2H-8,15-epoxy-7,13b-ethanope...
Literature References: A bitter principle isolated from Artemisia absinthium L., Compositae (wormwood). Isoln: F. Sorm et al., Chem. Ind. (London) 1955, 569; V. Herout et al., Collect. Czech. Chem. Commun. 21, 1485 (1956). Structure: L. Novotny et al., Chem. Ind. (London) 1958, 465; V. Herout et al., Collect. Czech. Chem. Commun. 25, 1492 (1960); J. Beauhaire et al., Tetrahedron Lett. 21, 3191 (1980).

Ultramarine CAS Registry Number: 1317-97-1

Additional Names: C.I. Pigment Blue 29; C.I. 77007
Literature References: A blue pigment occurring naturally as the mineral lapis lazuli. Made by igniting a mixture of kaolin, Na2CO3 (or Na2SO4), S and carbon. The resulting aluminosulfosilicates resemble zeolites structurally and have the approx formula Na7Al6Si6O24S3. See: Colour Index vol. 4 (3rd ed., 1971) p 4653.

Sodium Polystyrene Sulfonate CAS Registry Number: 9003-59-2 聚苯乙烯磺酸钠

Trademarks: Resonium A (Winthrop); Kayexalate (Sanofi Winthrop)
Literature References: A cation exchange resin charged with sodium.

Kinetin CAS Registry Number: 525-79-1 6-糠氨基嘌呤

CAS Name: N-(2-Furanylmethyl)-1H-purin-6-amine
Additional Names: N6-furfuryladenine; 6-furfurylaminopurine
Percent Composition: C 55.81%, H 4.22%, N 32.54%, O 7.43%
Literature References: A cell division factor found in various plant parts and in yeast. Isoln from autoclaved water slurries of deoxyribonucleic acid: Miller et al., J. Am. Chem. Soc. 77, 1392 (1955). Structure and synthesis from furfurylamine and 6-methylmercaptopurine: Miller et al., ibid. 2662; 78, 1375 (1956); US 2903455 (1959 to Wisc. Alumni Res. Found.). Physiologically active at very great dilutions, but only in presence of auxin, see Indoleacetic Acid. Crystal structure: M. Soriano-Garcia, R. Parthasarathy, Acta Crystallogr. 33B, 2674 (1977). Review: Miller, Annu. Rev. Plant Physiol. 12, 395 (1961).

Cyclic GMP CAS Registry Number: 7665-99-8 鸟苷3',5'-环一磷酸

CAS Name: Guanosine cyclic 3',5'-(hydrogen phosphate)
Additional Names: cyclic guanosine 3',5'-monophosphate; guanosine 3',5'-cyclic monophosphate; guanosine 3',5'-cyclic phosphate; guanosine 3...
Literature References: A cellular regulatory agent which has been described as a "second messenger". See Cyclic AMP. First synthesized because of the interest in cyclic nucleotides generated by cyclic AMP: Smith et al., J. Am. Chem. Soc. 83, 698 (1961); Borden, Smith, J. Org. Chem. 31, 3247 (1966). Has subsequently been found in animal and bacterial cells in concentrations of 10-8 to 10-6 moles/kg. First isoln from rat urine: Ashman et al., Biochem. Biophys. Res. Commun. 11, 330 (1963). Structure and conformation: Chwang, Sundaralingam, Nature New Biol. 244, 136 (1973). Proposed as an antagonist of cyclic AMP in bidirectional systems such as contraction-relaxation or glycogen synthesis-glycogen breakdown. Cyclic GMP levels increase in response to a variety of hormones including acetylcholine, insulin and oxytocin. Formed by conversion of guanosine triphosphate by the enzyme guanylate cyclase and hydrolyzed by cyclic nucleotide phosphodiesterases. Found to activate specific protein kinases. Reviews of biochemical model: Goldberg et al., in Pharmacology and the Future of Man vol. 5, R. A. Maxwell, G. H. Acheson, Eds. (Karger, New York, 1973) pp 146-169; eidem in Advan. Cyclic Nucleotide Res. vol. 3, P. Greengard, G. A. Robison, Eds. (Raven Press, New York, 1973) pp 155-223; Kolata, Science 182, 149-151 (1973); Nature 246, 186 (1973); N. D. Goldberg, M. K. Haddox, Annu. Rev. Biochem. 46, 823-896 (1977). Book: Handb. Exp. Pharmacol. 58, entitled "Cyclic Nucleotides", Pt. I: Biochemistry and Pt. II: Physiology Pharmacology, J. A. Nathanson, J. W. Kobabian, Eds. (Springer-Verlag, New York, 1982) 736 and 1000 pp resp.

Cephapirin Sodium CAS Registry Number: 24356-60-3 头孢匹林钠

CAS Name: (6R,7R)-3-[(Acetyloxy)methyl]-8-oxo-7-[[(4-pyridinylthio)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monosodium salt
Additional Names: 3-(hydroxymethyl)-8-oxo-...
Literature References: A cephalosporin C antibiotic effective against gram-pos. and gram-neg. bacteria including Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis. Prepn: L. B. Crast, ZA 6707783; eidem, US 3422100 (1968, 1970 both to Bristol-Myers). Alternate processes: H. H. Silvestri, D. A. Johnson, US 3503967; R. E. Havranek, L. B. Crast, US 3578661 (1970, 1971 both to Bristol-Myers); L. B. Crast et al., J. Med. Chem. 16, 1413 (1973). Activity studies: Chisholm et al., Antimicrob. Agents Chemother. 1969, 244; Axelrod et al., Appl. Microbiol. 22, 904 (1971); Bran et al., Antimicrob. Agents Chemother. 1, 35 (1972); Wiesner et al., ibid. 303.

Leucopterin CAS Registry Number: 492-11-5 无色喋呤

CAS Name: 2-Amino-5,8-dihydro-4,6,7(1H)-pteridinetrione
Additional Names: 2-amino-4,6,7-pteridinetriol; 2-amino-4,6,7-trihydroxypteridine; 2-amino-4,6,7-trihydroxypyrimido[4,5-b]pyrazine
Per...
Literature References: A colorless substance found in the wings of butterflies (especially of white-winged butterflies). May be obtained from xanthopterin by dehydrogenation: Wieland, Purrmann, Ann. 544, 172 (1940). Synthesis by fusing 2,4,5-triamino-6-hydroxypyrimidine with an excess of oxalic acid: Purrmann, ibid. 188. See also ref under Xanthopterin and review on pterins by Purrmann, Fortschr. Chem. Org. Naturst. 4, 64 (1945).

Ferric Citrate CAS Registry Number: 2338-05-8 (undefined); 28633-45-6 (undefined iron(III) salt); 3522-50-7 (1:1 iron(III) citrate salt) 柠檬酸铁(III) 一水合物

CAS Name: 2-Hydroxy-1,2,3-propanetricarboxylic acid iron salt
Literature References: A combination of iron and citric acid of indefinite composition. Prepn: Belloni, Gazz. Chim. Ital. 50, II, 159 (1920). Complex formation study: R. C. Warner, I. Weber, J. Am. Chem. Soc. 75, 5086 (1953). Polymerization studies: T. G. Spiro et al., ibid. 89, 5555, 5559 (1967). Role in iron uptake in plants: H. F. Bienfait, M. R. Scheffers, Plant Soil 143, 141 (1992). Tumorigenicity study in mice: K. Inai et al., Food Chem. Toxicol. 32, 493 (1994). Clinical evaluation in hyperphosphataemia: W.-C. Yang et al., Nephrol. Dial. Transplant. 17, 265 (2002).