其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Domiodol CAS Registry Number: 61869-07-6 多米奥醇

CAS Name: 2-(Iodomethyl)-1,3-dioxolane-4-methanol
Additional Names: 4-hydroxymethyl-2-iodomethyl-1,3-dioxolaneTrademarks: Mucolitico (Maggioni)
Percent Composition: C 24.61%, H 3.72%, I 52.0...
Literature References: Organic iodide mixture of cis and trans isomers. Prepn: M. Carissimi et al., DE 2610704; eidem, US 4085223 (1976, 1978 both to Maggioni). Prepn, expectorant and mucolytic activities: G. Cantarelli et al., Farmaco Ed. Prat. 34, 393 (1979). Pharmacology, toxicity: K. Kogi et al., Arzneim.-Forsch. 33, 1281 (1983). Separation of isomers and comparison of their pharmacological activity: M. Riva et al., ibid. 1091. Metabolism and tissue distribution in rats: T. Ohtsuki et al., Farmaco Ed. Prat. 39, 291 (1984). Comparative study with S-carboxymethylcysteine, q.v., in chronic obstructive lung disease: L. Casali et al., Int. J. Clin. Pharmacol. Ther. Toxicol. 20, 554 (1982).

Gallium Citrate CAS Registry Number: 27905-02-8; 30403-03-3 (unspecified stoichiometry) 枸橼酸镓

CAS Name: 2-Hydroxy-1,2,3-propanetricarboxylic acid gallium salt (1:1)
Percent Composition: C 27.84%, H 1.95%, Ga 26.94%, O 43.27%
Literature References: Organogallium complex administered to provide an aqueous source of gallium that accumulates in specific biological tissues. Prepd from gallium hydroxide and citric acid: P. Neogi, S. K. Nandi, J. Indian Chem. Soc. 13, 399 (1936); H. C. Dudley, J. Am. Chem. Soc. 72, 3822 (1950). Review of early clinical use as radiolabeled form: J. I. Hirsch et al., Drug Intel. Clin. Pharm. 7, 519-523 (1973). Mechanism studies of tumor localization: S. R. Vallabhajosula et al., Int. J. Nucl. Med. Biol. 8, 363 (1981); and metabolism: H. Kriegel, Nuklearmedizin 2, 53 (1984). Clinical management of lymphoma with SPECT/CT system: B. Palumbo et al., Eur. J. Nucl. Med. Mol. Imaging 32, 1011 (2005). Toxicity studies: H. C. Dudley et al., J. Pharmacol. Exp. Ther. 98, 409 (1950); H. D. Brunner, et al., Radiology 61, 550 (1953). Review of diagnostic use as imaging agent in oncology: H. A. Macapinlac et al., Nucl. Med. Biol. 21, 731-738 (1994); in infection: C. J. Palestro, Semin. Nucl. Med. 24, 128-141 (1994); in lymphoma: E. Even-Sapir, O. Israel, Eur. J. Nucl. Med. Mol. Imaging 30, Suppl. 1, S65-S81 (2003).

MMT CAS Registry Number: 12108-13-3

CAS Name: Tricarbonyl[(1,2,3,4,5-h)-1-methyl-2,4-cyclopentadien-1-yl]manganese
Additional Names: methylcyclopentadienylmanganese tricarbonyl; MCMT; tricarbonyl(h5-methylcyclopentadienyl)mangane...
Literature References: Organometallic antiknock compound used to increase the octane quality of fuel. Prepn: J. E. Brown et al., US 2818417 (1957 to Ethyl Corp.). Evaluation of antiknock properties: R. J. Riggs et al., Proc. 37th Natural Gas Assoc. Am. 1958, 51. Effect on auto emissions: W. R. Pierson et al., J. Air Pollut. Control. Assoc. 28, 692 (1978). Use as dopant in Mn deposition: K. Hirabayashi, H. Kozawaguchi, Jpn. J. Appl. Phys. 25, 711 (1986). Pyrolysis mechanism in deposition: S. Wen-bin et al., J. Cryst. Growth 113, 1 (1991); I. M. T. Davidson et al., J. Mater. Chem. 4, 13 (1994). GC determn in gasoline: W. A. Aue et al., Anal. Chem. 62, 2453 (1990); and in air: V. S. Gaind et al., Analyst 117, 161 (1992). Review as octane enhancer: J. D. Bailie, Oil Gas J. 74, 69-72 (1976); D. P. Hollrah, A. M. Burns, ibid. 89, 86-90 (1991). Review of toxicology: J. Stara et al., Proc. 4th Ann. Conf Environment. Toxicol. AD-781 031, 251-270 (1973); P. J. Abbott, Sci. Total Environ. 67, 247-255 (1987); and environmental assessment: D. R. Lynam et al., ibid. 93, 107-114 (1990.)

Phosalone CAS Registry Number: 2310-17-0 伏杀硫磷

CAS Name: Phosphorodithioic acid S-[(6-chloro-2-oxo-3(2H)-benzoxazolyl)methyl] O,O-diethyl ester
Additional Names: phosphorodithioic acid, O,O-diethyl ester, S-ester with 6-chloro-3-(mercaptome...
Literature References: Organophosphorous pesticide; cholinesterase inhibitor. Prepn: GB 1005372 (1965 to Rhône-Poulenc). Toxicology, metabolism, insecticidal properties: D. L. Colinese, H. J. Terry, Chem. Ind. (London) 1968, 1507. Use as molluscicide: Cessac, FR 1453989 (1966 to Rhône-Poulenc).

Tolclofos-methyl CAS Registry Number: 57018-04-9 甲基立枯磷

CAS Name: O-(2,6-Dichloro-4-methylphenyl)phosphorothioic acid O,O-dimethyl ester
Additional Names: O-(2,6-dichloro-p-tolyl) O,O-dimethyl phosphorothioate; tolclophos-methylTrademarks: Rizolex (...
Literature References: Organophosphorus fungicide; inhibits phospholipid biosynthesis. Prepn: T. Kato et al., DE 2501040; GB 1467561 (1975, 1977 both to Sumitomo). Properties and biological activity: S. Ohtsuki, A. Fujinami, Jpn. Pestic. Inf. 41, 21 (1982). Synthesis: M. Sasaki et al., J. Pestic. Sci. 9, 737 (1984). Mode of action: S. Nakamura, T. Kato, ibid. 725; P. Leroux et al., Pestic. Sci. 36, 255 (1992). GC determn in soil, lettuce: M. Gennari et al., J. AOAC Int. 80, 1298 (1997). Control of bottom rot on lettuce: J. R. Coley-Smith et al., Plant Pathol. 40, 359 (1991).

Phenylselenotrimethylsilane CAS Registry Number: 33861-17-5 三甲基苯基硒硅烷

CAS Name: Trimethyl(phenylseleno)silane
Additional Names: trimethylsilyl phenyl selenide; PSTMS
Percent Composition: C 47.15%, H 6.16%, Se 34.44%, Si 12.25%
Literature References: Organoselenium compound for the introduction of selenium into molecules. Prepn: N. Y. Derkach et al., Zh. Org. Khim. 7, 1543 (1971); and use: D. Liotta et al., Tetrahedron Lett. 1978, 5091. Improved synthesis: N. Miyoshi et al., Synthesis 1979, 300. Synthetic applications: S. D. Rychnovsky, D. J. Skalitzky, Synlett 1995, 555; H. Abe et al., Chem. Pharm. Bull. 46, 1311 (1998); M. W. DeGroot, J. F. Corrigan, Dalton 2000, 1235. Brief review: M. David, Synlett 2001, 445.

Aricine CAS Registry Number: 482-91-7 阿立新鹼

CAS Name: (19a,20a)-16,17-Didehydro-10-methoxy-19-methyloxayohimban-16-carboxylic acid methyl ester
Additional Names: quinovatine; cinchovatine; heterophylline
Percent Composition: C 69.09%,...
Literature References: Originally found in Cusco bark, the bark of Cinchona pelletierana Wedd., Rubiaceae: Pelletier, Coriol, J. Pharm. Chim. [2] 15, 565 (1829). Also from Rauwolfia canescens L., R. heterophylla Roem. Schult., R. sellowii Muell. Argov. and Aspidosperma marcgravianum Woodson., Apocynaceae: Stoll et al., Helv. Chim. Acta 38, 270 (1955); Hochstein et al., J. Am. Chem. Soc. 77, 3551 (1955); Hochstein, ibid. 77, 5744 (1955); Gilbert et al., J. Org. Chem. 27, 4702 (1962). Structure: Stoll et al., loc. cit. Stereochemistry: Neuss, Boaz, J. Org. Chem. 22, 1001 (1957); Shamma, Richey, J. Am. Chem. Soc. 85, 2507 (1963).

Dicumarol CAS Registry Number: 66-76-2 双羟香豆素

CAS Name: 3,3'-Methylenebis[4-hydroxy-2H-1-benzopyran-2-one]
Additional Names: 3,3'-methylenebis[4-hydroxycoumarin]; bishydroxycoumarin (rescinded)
Trademarks: Dicoumarol; Dicoumarin; Dicumo...
Literature References: Originally isolated from spoiled sweet clover (improperly cured Melilotus hay): Link et al., J. Biol. Chem. 138, 21, 513, 529 (1941); 142, 941 (1942); now prepd synthetically by the action of formaldehyde on 4-hydroxycoumarin (obtained as the Na derivative by the action of sodium metal on methyl acetylsalicylate): Link, Fed. Proc. 4, 176 (1945), and patents (The Wisconsin Alumni Res. Found.). Toxicity data: Rose et al., Proc. Soc. Exp. Biol. Med. 50, 228 (1942).

Uredepa CAS Registry Number: 302-49-8 乌瑞替哌

CAS Name: [Bis(1-aziridinyl)phosphinyl]carbamic acid ethyl ester
Additional Names: ethyl [bis(1-aziridinyl)phosphinyl]carbamate; ethyl N-[bis(ethyleneimido)phosphoro]carbamate; bis(ethylenimido...
Literature References: Outline of prepn: Bardos et al., Nature 183, 399 (1959); Bardos, Papanastassiou, US 3201313 (1965 to Armour Pharm.).

Moxalactam CAS Registry Number: 64952-97-2 拉氧头孢

CAS Name: (6R,7R)-7-[[(2R)-Carboxy(4-hydroxyphenyl)acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Additional Name...
Literature References: Oxa-substituted third generation cephalosporin antibiotic (oxacephalosporin). Prepn: M. Narisada, W. Nagata, DE 2713370; eidem, US 4138486 (1977, 1979 both to Shionogi); M. Narisada et al., J. Med. Chem. 22, 757 (1979). Laboratory evaluation: T. Yoshida et al., Antimicrob. Agents Chemother. 17, 302 (1980). Mechanism of action study: Y. Komatsu, T. Nishikawa, ibid. 316. Pharmacokinetics: R. Wise et al., ibid. 18, 369 (1980). Comparative in vitro activity: T. O. Kurtz et al., ibid. 645. Series of articles on pharmacology, teratology, toxicity studies: Chemotherapy (Tokyo) 28, Suppl. 7, 1002-1235 (1980). Clinical evaluation in neonates and infants: U. B. Schaad et al., J. Pediatr. 98, 129 (1981). Review: Rev. Infect. Dis. 4, Suppl., S489-S726 (1982).