网站主页>>>项目整合精选>>>项目整合精选>>>Domiodol CAS Registry Number: 61869-07-6 多米奥醇

Domiodol CAS Registry Number: 61869-07-6 多米奥醇

CAS Name: 2-(Iodomethyl)-1,3-dioxolane-4-methanol
Additional Names: 4-hydroxymethyl-2-iodomethyl-1,3-dioxolaneTrademarks: Mucolitico (Maggioni)
Percent Composition: C 24.61%, H 3.72%, I 52.00%, O 19.67%

📌 参考资料/链接：
Literature References: Organic iodide mixture of cis and trans isomers. Prepn: M. Carissimi et al., DE 2610704; eidem, US 4085223 (1976, 1978 both to Maggioni). Prepn, expectorant and mucolytic activities: G. Cantarelli et al., Farmaco Ed. Prat. 34, 393 (1979). Pharmacology, toxicity: K. Kogi et al., Arzneim.-Forsch. 33, 1281 (1983). Separation of isomers and comparison of their pharmacological activity: M. Riva et al., ibid. 1091. Metabolism and tissue distribution in rats: T. Ohtsuki et al., Farmaco Ed. Prat. 39, 291 (1984). Comparative study with S-carboxymethylcysteine, q.v., in chronic obstructive lung disease: L. Casali et al., Int. J. Clin. Pharmacol. Ther. Toxicol. 20, 554 (1982).

📄 详细内容

Properties: LD50 in male, female mice (mg/kg): 79, 89 i.p.; 140, 145 orally (Riva).
Toxicity data: LD50 in male, female mice (mg/kg): 79, 89 i.p.; 140, 145 orally (Riva)
Derivative Type: cis-Form
Properties: bp0.2 106-108°. LD50 orally in male mice: 135 mg/kg (Riva).
Boiling point: bp0.2 106-108°
Toxicity data: LD50 orally in male mice: 135 mg/kg (Riva)
Derivative Type: trans-Form
Properties: bp0.2 114-116°. LD50 orally in male mice: 150 mg/kg (Riva).
Boiling point: bp0.2 114-116°
Toxicity data: LD50 orally in male mice: 150 mg/kg (Riva)
Therap-Cat: Mucolytic.
Keywords: Mucolytic.
产品链接: 61869-07-6››

← 返回产品列表