其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Quinaldine CAS Registry Number: 91-63-4 2-甲基喹啉

CAS Name: 2-Methylquinoline
Percent Composition: C 83.88%, H 6.34%, N 9.78%
Literature References: Occurs in coal tar; made from aniline, acetaldehyde and HCl. Lab procedure: A. I. Vogel, Practical Organic Chemistry (Longmans, London, 3rd ed., 1959) p 831; Gattermann-Wieland, Praxis des Organischen Chemikers (de Gruyter, Berlin, 40th ed., 1961) p 318. Pharmacology: Brown et al., Comp. Biochem. Physiol. 42A, 223 (1972). Toxicity data: Smyth et al., Arch. Ind. Hyg. Occup. Med. 4, 119 (1951); L. L. Marking, Invest. Fish Control 23, 3 (1969).

Betonicine CAS Registry Number: 515-25-3 左旋水苏碱

CAS Name: (2S-trans)-2-Carboxy-4-hydroxy-1,1-dimethylpyrrolidinium inner salt
Additional Names: l-N,N-dimethyl-4-hydroxypyrrolidine-2-carboxylic acid betaine; l-1-methyl-4-hydroxypyrrolidine-2-...
Literature References: Occurs in Croton gubouga S. Moore; in Stachys officinalis (L.) Trev. (Betonica officinalis L.), Labiatae; in Achillea moschata Jacq. and A. millefolium L., Compositae: Goodson, Clewer, J. Chem. Soc. 115, 923 (1919); Guggenheim, Die biogenen Amine (S. Karger, New York, 1951) p 246; Miller, Chow, J. Am. Chem. Soc. 76, 1353 (1954); Pailer, Kump, Monatsh. Chem. 90, 396 (1959); Arch. Pharm. 293, 646 (1960). Stereoisomeric with turicine (cis-form). Synthesis: Patchett, Witkop, J. Am. Chem. Soc. 79, 185 (1957).

Apiole (Dill) CAS Registry Number: 484-31-1 6-烯丙基-4,5-二甲氧基苯并[d][1,3]二恶唑

CAS Name: 4,5-Dimethoxy-6-(2-propenyl)-1,3-benzodioxole
Additional Names: 1-allyl-2,3-dimethoxy-4,5-(methylenedioxy)benzene; dill apiole
Percent Composition: C 64.85%, H 6.35%, O 28.80%
Literature References: Occurs in dill oil, Anethum graveolus L., Umbelliferae. Isoln: G. Ciamician, P. Silber, Ber. 29, 1799 (1896); D. B. Spoelstra, Rec. Trav. Chim. 48, 372 (1929). Structure: H. Thoms, Arch. Pharm. 242, 344 (1904). Synthesis: W. Baker et al., J. Chem. Soc. 1934, 1681; F. Dallacker, Ber. 102, 2663 (1969); J. R. Cannon et al., J. Sci. Soc. Thailand 6, 59 (1980). Synergistic activity with insecticides: E. P. Lichtenstein et al., J. Agric. Food Chem. 22, 658 (1974); S.S. Tomar et al., Agric. Biol. Chem. 43, 1479 (1979).

Tripalmitin CAS Registry Number: 555-44-2 (三)棕榈酸甘油酯

CAS Name: Hexadecanoic acid 1,2,3-propanetriyl ester
Additional Names: palmitin; glyceryl tripalmitate
Percent Composition: C 75.87%, H 12.24%, O 11.89%
Literature References: Occurs in fats. Prepd from glycerol and palmitic acid in the presence of Twitchell reagent: Ozaki, Biochem. Z. 177, 159 (1926); or in the presence of trifluoroacetic anhydride: Bourne et al., J. Chem. Soc. 1949, 2976.

Gentisic Acid CAS Registry Number: 490-79-9 2,5-二羟基苯甲酸

CAS Name: 2,5-Dihydroxybenzoic acid
Additional Names: 5-hydroxysalicylic acid
Percent Composition: C 54.55%, H 3.92%, O 41.52%
Literature References: Occurs in gentian: Redgrove, Pharm. J. 122, 324 (1929). Found in urine of dogs after ingestion of salicylates: Neuberg, Berl. Klin. Wochenschr. 48, 799 (1911). Prepd from hydroquinone: Senhofer, Sarlay, Monatsh. Chem. 2, 448 (1881); Juch, ibid. 26, 839 (1905); Brunner, Ann. 351, 321 (1907); Zeltner, Landau, DE 258887; Frdl. 11, 210; Dyson, Manual of Organic Chemistry vol. I (London, 1950) p 614; by oxidation of salicylic acid with potassium persulfate: DE 81297 (to Schering AG); Frdl. 4, 127; from p-hydroxyphenol: Meyer, US 2588336 (1952 to Monsanto); from 5-bromo-2-hydroxybenzoic acid: Lowenthal, Pepper, J. Am. Chem. Soc. 72, 3292 (1950); by Kolbe synthesis: Clemens, US 2816137 (1957 to Eastman Kodak). Metabolic product of Penicillium patulum: Tanenbaum, Bassett, Biochim. Biophys. Acta 28, 21 (1958); of Polyporus tumulosus Cooke: Crowden, Ralph, Aust. J. Chem. 14, 475 (1961). Biosynthesis: Gatenback, Linnroth, Acta Chem. Scand. 16, 2298 (1962).

Cholestanol CAS Registry Number: 80-97-7 二氢胆固醇

CAS Name: (3b,5a)-Cholestan-3-ol
Additional Names: Dihydrocholesterol; 3b-hydroxycholestane; b-cholestanol
Percent Composition: C 83.44%, H 12.45%, O 4.12%
Literature References: Occurs in human feces, in gallstones, in eggs. Prepn by reduction of cholesterol: Willstätter, Mayer, Ber. 41, 2199 (1908); Ellis, Gardner, Biochem. J. 12, 72 (1918). From coprostenone: Diels, Abderhalden, Ber. 39, 884 (1906). See also Bruce, Ralls, Org. Synth. coll. vol. II, 191 (1943).

Tephrosin CAS Registry Number: 76-80-2 灰叶草素, 羟基鱼藤素

CAS Name: (7aR-cis)-13,13a-Dihydro-7a-hydroxy-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7aH)-one
Additional Names: hydroxydeguelin; toxicarol
Percent Composition...
Literature References: Occurs in leaves of Tephrosia vogelii Hook. f., Leguminosae, in derris root, cubé root: Hanriot, Compt. Rend. 144, 150 (1907); Clark, J. Am. Chem. Soc. 53, 729 (1931). Structure: Butenandt, Hilgetag, Ann. 495, 172 (1932).

Thianaphthene CAS Registry Number: 95-15-8 苯并噻吩

CAS Name: Benzo[b]thiophene
Additional Names: benzothiofuran
Percent Composition: C 71.60%, H 4.51%, S 23.89%
Literature References: Occurs in lignite tar. Catalytic synthesis from styrene and hydrogen sulfide: Moore, Greensfelder, J. Am. Chem. Soc. 69, 2008 (1947); from ethyl benzene and hydrogen sulfide: Hansch, Hawthorne, ibid. 70, 2495 (1948).

Fumaric Acid CAS Registry Number: 110-17-8 富马酸,反丁烯二酸

CAS Name: (2E)-2-Butenedioic acid
Additional Names: trans-1,2-ethylenedicarboxylic acid; allomaleic acid; boletic acid
Percent Composition: C 41.39%, H 3.47%, O 55.14%
Literature References: Occurs in many plants, e.g., in Fumaria officinalis L., Fumariaceae, in Boletus scaber Bull., Boletaceae, and in Fomes igniarius (Fries) Kickx., Polyporaceae. Essential to vegetable and animal tissue respiration. Prepd industrially from glucose by the action of fungi such as Rhizopus nigricans: Foster, Waksman, J. Am. Chem. Soc. 61, 127 (1939). Laboratory prepn by the oxidation of furfural with sodium chlorate in the presence of vanadium pentoxide: Milas, Org. Synth. coll. vol. II, 302 (1943). Molecular structure: J. L. Derissen, J. Mol. Struct. 38, 177 (1977). Review: W. D. Robinson, R. A. Mount in Kirk-Othmer Encyclopedia of Chemical Technology vol. 14 (Wiley-Interscience, New York, 3rd ed., 1981) pp 770-793.

Orcinol CAS Registry Number: 504-15-4 3,5-二羟基甲苯

CAS Name: 5-Methyl-1,3-benzenediol
Additional Names: 5-methylresorcinol; orcin; 3,5-dihydroxytoluene
Percent Composition: C 67.73%, H 6.50%, O 25.78%
Literature References: Occurs in many species of lichens: Sastry, Rao, Curr. Sci. 10, 437 (1941). Prepn: Anker, Cook, J. Chem. Soc. 1945, 311; Kisteneva, Rozhdestvenskii, Zh. Prikl. Khim. 22, 1108 (1949); Stevens, US 2603662 (1952 to Gulf); Zimmer, US 3028410 (1962 to Hooker Chem.). Toxicity studies: I. Veldre et al., Vopr. Gig. Tr. Prof. Patol. Est. SSR 2, 160 (1970), C.A. 74, 51746h (1971).