其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

b -Boswellic Acid CAS Registry Number: 631-69-6 β-乳香酸

CAS Name: (3a,4b)-3-Hydroxyurs-12-en-23-oic acid
Percent Composition: C 78.90%, H 10.59%, O 10.51%
Literature References: Occurs as the acetate in frankincense (olibanum) from Boswellia carterii, Burseraceae. The b-form is predominant and is accompanied by small amounts of a- and g-boswellic acid. Isoln from olibanum tears: Winterstein, Stein, Z. Physiol. Chem. 208, 9 (1932). Early structural studies: Simpson, Williams, ibid. 1938, 686, 1712; Ruzicka, Wirz, Helv. Chim. Acta 22, 948 (1939); 23, 132 (1940); Ruzicka et al., ibid. 27, 1859 (1944). Revised structure and stereochemistry: Beton et al., J. Chem. Soc. 1956, 2904; Allan, Chimia 17, 382 (1963); idem, Phytochemistry 7, 963 (1968). Review: J. Simonsen, W. C. J. Ross, The Terpenes vol. 5 (University Press, Cambridge, 1957) pp 68-74.

Rhamnose CAS Registry Number: 3615-41-6 α-鼠李糖

CAS Name: 6-Deoxy-L-mannose
Additional Names: L-rhamnose; L-mannomethylose; isodulcit
Percent Composition: C 43.90%, H 7.37%, O 48.73%
Literature References: Occurs free in poison sumac (Rhus toxicodendron L., Anacardiaceae), combined in the form of glycosides of many plants. Preparation: Clark, J. Biol. Chem. 38, 255 (1919). Structure and configuration: Fischer, Morrell, Ber. 27, 384 (1894); Fischer, Zach, ibid. 45, 3762 (1912); Hirst, Macbeth, J. Chem. Soc. 1926, 23; Avery, Hirst, ibid. 1929, 2466. Isoln from walls of gram-negative bacteria: Salton, Biochim. Biophys. Acta 45, 364 (1960); from Afraegle paniculata Engl., Rutaceae: Torto, J. Chem. Soc. 1961, 5234; from rabbit skin: Malawista, Davidson, Nature 192, 871 (1961); from leaves of Solanum chacoense Bitter, Solanaceae: Kuhn, Löw, Ber. 94, 1088 (1961).

Benzyl Acetate CAS Registry Number: 140-11-4 乙酸苄酯

CAS Name: Acetic acid phenylmethyl ester
Additional Names: acetic acid benzyl ester
Percent Composition: C 71.98%, H 6.71%, O 21.31%
Literature References: Occurs in a number of plants, particularly jasmine: S. Arctander, Perfume and Flavor Materials of Natural Origin (Elizabeth, N.J., 1960) pp 313-314. Prepd from benzyl chloride, acetic acid or sodium acetate and triethylamine: Merker, Scott, J. Org. Chem. 26, 5180 (1961); Hennis et al., Ind. Eng. Chem. Prod. Res. Dev. 6, 193 (1967). Toxicity study: P. M. Jenner et al., Food Cosmet. Toxicol. 2, 327 (1964).

Allopregnane-3 b ,17 a ,21-triol-11,20-dione CAS Registry Number: 516-45-0 (3beta,5alpha)-3,17,21-三羟基孕甾烷e-11,20-二酮

CAS Name: 3b,17,21-Trihydroxy-5a-pregnane-11,20-dione
Additional Names: 3b,17,21-trihydroxy-11,20-dioxo-5a-pregnane; 17-(1-keto-2-hydroxyethyl)androstane-3,17-diol-11-one; Kendall's compound G;...
Literature References: Occurs in adrenal cortex: Kuizenga, Cartland, Endocrinology 24, 526 (1939); von Euw, Reichstein, Helv. Chim. Acta 25, 988 (1942); 41, 1516 (1958). Prepn by reduction of allopregnane-17a,21-diol-3,11,20-trione: Kaufmann, Pataki, Experientia 7, 260 (1951); from 5a-pregnan-3b-ol-11,20-dione: Chamberlin, Chemerda, J. Am. Chem. Soc. 77, 1221 (1955).

Allopregnane-3 b ,11 b ,17 a ,20 b ,21-pentol CAS Registry Number: 516-39-2 (3beta,5alpha,11beta)-孕甾烷-3,11,17,20,21-五醇

CAS Name: 5a-Pregnane-3b,11b,17,20b,21-pentol
Additional Names: 3b,11b,17,20b,21-pentahydroxy-5a-pregnane; 17-(1,2-dihydroxyethyl)androstane-3,11,17-triol; Kendall's compound D; Reichstein's su...
Literature References: Occurs in adrenal cortex: Mason et al., J. Biol. Chem. 114, 613 (1936). Prepn from 21-acetoxy-3b,17a-dihydroxy-5a-pregnane-11,20-dione + lithium aluminum hydride: Klyne, Ridley, J. Chem. Soc. 1956, 4825; by hydrogenation of cortisol with platinum oxide: Caspi, J. Org. Chem. 24, 669 (1959).

Deoxycorticosterone CAS Registry Number: 64-85-7 去氧皮质酮

CAS Name: 21-Hydroxypregn-4-ene-3,20-dione
Additional Names: 4-pregnen-21-ol-3,20-dione; 21-hydroxyprogesterone; desoxycorticosterone; 11-deoxycorticosterone; cortexone; desoxycortone; Kendall'...
Literature References: Occurs in adrenal cortex: Reichstein, von Euw, Helv. Chim. Acta 21, 1197 (1938); Steiger, Reichstein, ibid. 20, 1164 (1937). Numerous prepns from other steroids: Schindler et al., ibid. 24, 371 (1941); Reichstein, DE 875353 (1953 to Schering); Bockmühl et al., DE 871153 (1953 to Hoechst); Wettstein et al., US 2778776 (1957 to Ciba); NL 89575 (1958 to Organon); Kaspar et al., DE 1028572 (1958 to Schering). Isoln from the prothoracal glands of the water beetle, Dytiscus marginalis: Schildknecht et al., Angew. Chem. 78, 392 (1966).

Creosol CAS Registry Number: 93-51-6 2-甲氧基-4-甲基苯酚

CAS Name: 2-Methoxy-4-methylphenol
Additional Names: 2-methoxy-p-cresol; 4-methylguaiacol; 3-methoxy-4-hydroxytoluene; 4-hydroxy-3-methoxy-1-methylbenzene
Percent Composition: C 69.55%, H 7....
Literature References: Occurs in beechwood tar. It is one of the active constituents of creosote. Obtained by the Clemmensen reduction of vanillin using amalgamated zinc and toluene as auxiliary solvent: Fletcher, Tarbell, J. Am. Chem. Soc. 65, 1431 (1943); Schwarz, Hering, Org. Synth. coll. vol. IV, 203 (1963).

Epiquinidine CAS Registry Number: 572-59-8 表奎宁定

CAS Name: (9R)-6'-Methoxycinchonan-9-ol
Percent Composition: C 74.04%, H 7.46%, N 8.63%, O 9.86%
Literature References: Occurs in cinchona bark. Isoln from quinoidine: Dirscherl, Thron, Ann. 521, 48 (1938). By epimerization of quinine or quinidine: Rabe, Höter, J. Prakt. Chem. 154, 66 (1940). Stereochemistry: Prelog, Zalán, Helv. Chim. Acta 27, 535, 545 (1944); Prelog, Häfliger, ibid. 33, 2021 (1950); Roth, Pharmazie 16, 257 (1961). Synthesis: Grethe et al., Helv. Chim. Acta 55, 1044 (1972); Gutzwiller, Uskokovic, ibid. 56, 1494 (1973).

Mesitylene CAS Registry Number: 108-67-8 均三甲苯

CAS Name: 1,3,5-Trimethylbenzene
Additional Names: sym-trimethylbenzene
Percent Composition: C 89.94%, H 10.06%
Literature References: Occurs in coal tar and in petroleum crudes; prepd by dehydrating acetone with H2SO4: Adams, Hufferd, Org. Synth. 2, 41 (1922).

Isodurene CAS Registry Number: 527-53-7 1,2,3,5-四甲基苯

CAS Name: 1,2,3,5-Tetramethylbenzene
Percent Composition: C 89.49%, H 10.51%
Literature References: Occurs in coal tar. Prepd by the action of dimethyl sulfate on 2,4,6-trimethylphenylmagnesium bromide: Smith, Org. Synth. 11, 66 (1931).