其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Bis(triphenylphosphine)dicarbonylnickel CAS Registry Number: 13007-90-4 双(三苯基膦)二羰基镍

CAS Name: Dicarbonylbis(triphenylphosphine)nickel
Additional Names: dicarbonyldi(triphenylphosphino)nickel
Percent Composition: C 71.39%, H 4.73%, Ni 9.18%, O 5.01%, P 9.69%
Literature References: Obtained by reacting one mole of nickel carbonyl with two moles of triphenylphosphine: Reppe, Schweckendiek, Ann. 560, 104 (1948); Rose, Statham, J. Chem. Soc. 1950, 69. Also by reacting CO with a methanol soln of triphenylphosphine and reduced Ni at 170° and 60 atm: Yamamoto, Oku, Bull. Chem. Soc. Jpn. 27, 382 (1954), C.A. 49, 6856 (1955).

Isobutyl Urethane CAS Registry Number: 539-89-9 N-异-丁基脲烷

CAS Name: (2-Methylpropyl)carbamic acid ethyl ester
Percent Composition: C 57.90%, H 10.41%, N 9.65%, O 22.04%
Literature References: Obtained by shaking isobutylamine with ethyl chloroformate and aq KOH in the cold.

Methyl Isothiocyanate CAS Registry Number: 556-61-6 异硫氰酸甲酯

CAS Name: Isothiocyanatomethane
Additional Names: methyl mustard oil
Trademarks: Trapex
Percent Composition: C 32.85%, H 4.14%, N 19.16%, S 43.85%
Literature References: Obtained by the action of CS2 on methylamine. Antibacterial activity: P. Klesse, P. Lukoschek, Arzneim.-Forsch. 5, 505 (1955). Toxicity data: E. H. Vernot et al., Toxicol. Appl. Pharmacol. 42, 417 (1977). Headspace determn in wine: N. Gandini, R. Riguzzi, J. Agric. Food Chem. 45, 3092 (1997). Soil degradation study: A. Frick et al., J. Environ. Qual. 27, 1158 (1998).

Etofylline CAS Registry Number: 519-37-9 7-(2-羟基乙基)茶碱

CAS Name: 3,7-Dihydro-7-(2-hydroxyethyl)-1,3-dimethyl-1H-purine-2,6-dione
Additional Names: 7-(2-hydroxyethyl)theophylline; oxyethyltheophylline
Trademarks: Oxytheonyl; Oxphylline (Amido); P...
Literature References: Obtained by the action of glycol monochlorohydrin upon theophylline in an alkaline medium: Lespagnol et al., Bull. Soc. Pharm. Lille 1948, no. 2, p 18; Roth, Arch. Pharm. 292, 234 (1959); Fabbrini, Cencioni, Farmaco Ed. Sci. 17, 660 (1962).

Phthaloyl Chloride CAS Registry Number: 88-95-9 邻苯二甲酰氯

CAS Name: 1,2-Benzenedicarbonyl dichloride
Percent Composition: C 47.33%, H 1.99%, Cl 34.93%, O 15.76%
Literature References: Obtained by the action of PCl5 on phthalic anhydride.

Propylidene Chloride CAS Registry Number: 78-99-9 1,1-二氯丙烷

CAS Name: 1,1-Dichloropropane
Percent Composition: C 31.89%, H 5.35%, Cl 62.75%
Literature References: Obtained by the action of PCl5 on propionaldehyde. Toxicity data: Smyth et al., Arch. Ind. Hyg. Occup. Med. 10, 61 (1954).

Guaiacol Phosphate CAS Registry Number: 563-03-1 三(2-甲氧基苯基)磷酸酯

Percent Composition: C 60.58%, H 5.08%, O 26.90%, P 7.44%
Literature References: Obtained by the action of POCl3 upon guaiacol sodium: Kucherov, Zh. Obshch. Khim. 19, 126 (1949). Prepn of sodium salt: Auger, Dupuis, Compt. Rend. 146, 1151 (1908).

Isophthalic Acid CAS Registry Number: 121-91-5 间苯二甲酸(IPA)

CAS Name: 1,3-Benzenedicarboxylic acid
Additional Names: m-phthalic acid
Percent Composition: C 57.84%, H 3.64%, O 38.52%
Literature References: Obtained by the oxidation of m-xylene: Smith, J. Am. Chem. Soc. 43, 1920 (1921); Weisemann, Fragen, Proc. 5th World Petrol. Congr. 4, 197 (1960); Brill, Ind. Eng. Chem. 52, 837 (1960); Bhattacharyya, Ganguly, J. Indian Chem. Soc. 38, 463 (1961); Saffer, Barker, US 3089906 (1963 to Mid-Century Corp.); Hay, GB 951192 (1964 to General Electric).

Chloroacetyl Isocyanate CAS Registry Number: 4461-30-7 氯乙酰异氰酸酯

Additional Names: Chloroacetic acid anhydride with isocyanic acid
Percent Composition: C 30.15%, H 1.69%, Cl 29.67%, N 11.72%, O 26.77%
Literature References: Obtained by the reaction of chloroacetamide with oxalyl chloride: Speziale, Smith, J. Org. Chem. 28, 1808 (1963).

Glucoheptonic Acid CAS Registry Number: 87-74-1 D-甘油-L-葡萄糖-庚酸

CAS Name: D-glycero-D-gulo-Heptonic acid
Additional Names: a-glucoheptonic acid; glucosemonocarboxylic acid; glucomonocarbonic acid
Percent Composition: C 37.17%, H 6.24%, O 56.59%
Literature References: Obtained by treating glucose with HCN yielding a cyanohydrin which is saponified to glucoheptonic acid: Kiliani, Ber. 19, 769 (1886); Fischer, Ann. 270, 71 (1892); Armestar, C.A. 45, 2865 (1951). Process starting with calcium cyanide and glucose: Clevenot, US 2735866 (1956 to Lab. Clevenot). Diagnostic use of 99mTc complexes in renal scintigraphy: R. E. Boyd et al., Br. J. Radiol. 46, 604 (1973); in brain scanning: J. Léveillé et al., J. Nucl. Med. 18, 957 (1977); T. W. Ryerson et al., Radiology 127, 429 (1978). Subacute toxicity study: L. Belbeck et al., Can. J. Comp. Med. 45, 299 (1981).