CAS: 993-07-7; Trimethylsilane

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CAS号75-77-4 三甲基氯硅烷 | CAS号16853-85-3 氢化铝锂 | CAS号290333-18-5 2-Me2N-α-Me3Si-... | CAS号83268-94-4 2-allyl-2-metho... | CAS号6651-36-1 1-环己烯氧基三甲基硅烷 | CAS号83268-89-7 2-cyclopropyl-2... | CAS号75-54-7 甲基二氯硅烷 | CAS号917-54-4 甲基锂 | CAS号83268-92-2 2-methoxy-1,1,1... | CAS号5089-32-7 trimethyl(trime... | CAS号6231-76-1 1,2-ethanediylb... | CAS号18140-32-4 2-(dichlorometh... | CAS号3353-69-3 1,2-二(甲基二氯硅基)乙烷 | CAS号4551-15-9 (苯硫基)三甲基硅烷 | CAS号14629-58-4 [2-(Trimethylsi... | CAS号3844-94-8 1-三甲基硅基-1-己炔 | CAS号18151-58-1 2-trimethylsily... | CAS号124582-84-9 1,1,1-trimethyl... | CAS号18151-32-1 2-氰基乙基三甲基硅烷

三甲基溴硅烷置于2,2,6,6-四甲基哌啶,氢气,Tris(2,6-Difluorophenyl)Borane体系中,用 氘代苯 作为反应溶剂,25.0 °C,1.0 Mpa 条件下,反应 16.0H,以71%的收率获得产物三甲基硅烷
参考文献:甲硅烷基三氟甲磺酸酯和卤化物无金属催化氢解成氢硅烷**
标题:甲硅烷基三氟甲磺酸酯和卤化物无金属催化氢解成氢硅烷**
摘要:甲硅烷基三氟甲磺酸酯和卤化物无金属氢解成氢硅烷的过程被解锁.这是通过使用与金属催化剂竞争的硼基有机催化剂来实现的.
DOI:10.1002/anie.202200911

专利信息

专利号:US-7247752-B2
优先权日:2004-10-01
标 题 :Methods for the synthesis of astaxanthin
发明人：LOCKWOOD SAMUEL F; TANG PENG CHO; NADOLSKI GEOFF; JACKSON HENRY L; FANG ZHIQIANG; DU YISHU; YANG MIN; GEISS WILLIAM; WILLIAMS RICHARD; BURDICK DAVID
权利人:CARDAX PHARMACEUTICALS INC
摘要:A method used for synthesizing intermediates for use in the synthesis of carotenoids and carotenoid analogs, and/or carotenoid derivatives. In some embodiments, the invention includes methods for synthesizing optically active intermediates useful for the synthesis of optically active carotenoids. Synthesis of optically active carotenoids, in one embodiment, may be accomplished by forming an optically active dihydroxy intermediate from ketoisopherone. The optically active dihydroxy intermediate may be converted into optically active astaxanthin derivatives.

专利号:US-7956011-B2
优先权日:2005-05-04
标题:Materials and methods for the photodirected synthesis of oligonucleotide arrays
发明人：SERAFINOWSKI PAWEL JERZY; GARLAND PETER BRYAN
权利人:CANCER RES INST ROYAL
摘要:Materials and methods for photodirected synthesis of oligonucleotide arrays on a solid substrate by photodirected synthesis are disclosed which employ a film formed from (i) a photoacid generator that on photolysis generates acid that is capable of directly removing the protecting group of the linker molecules or oligonucleotides and (ii) a polymer substantially lacking electronegative heteroatoms that are capable of hydrogen bonding with photogenerated acid. Methods of synthesizing an oligomer arrays are also described that use a film that restricts diffusion of reactants and products on the substrate during synthesis of the array and which includes a precursor of a deprotecting reagent. The method involves removing one or more of the non-required products of the deprotection reaction from the reactive array elements at which they are produced during the reaction, in order to displace the deprotection reaction towards completion.

专利号:US-10889599-B2
优先权日:2018-02-27
标 题:1,1-diborylalkyl-1-metal compounds, preparation method thereof, and their applications toward synthesis of 1,1-diboronate ester compounds
发明人：CHO SEUNG HWAN; LEE YEOSAN
权利人:POSTECH ACAD IND FOUND
摘要:The present invention relates to a 1,1-diborylalkyl-1-metal compound including one metal group together with two identical boron groups at the sp3 carbon center, and its use. Specifically, the present invention relates to development of novel organic reactions, synthesis of functional molecules, and synthesis of new drugs by applying the novel 1,1-diboryl-1-metal substituted alkyl compounds to various molecular libraries which could not be synthesized by conventional methodologies.

专利号:US-7202370-B2
优先权日:2003-10-27
标 题 :Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
发明人：NAIDU RAGINA
权利人:CONOR MEDSYSTEMS INC
摘要:A method is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel from 9-dihydro-13-acetylbaccatin III. The preparation of a suitably protected baccatin III backbone from 9-dihydro-13-acetylbaccatin III, and the insertion of the phenylisoserine side chain onto the protected baccatin III from 9-dihydro-13-acetylbaccatin III to form the taxane derivatives, paclitaxel and docetaxel is disclosed.

专利号:US-8722886-B1
优先权日:2012-11-13
标题:Methods for the total chemical synthesis of enantiomerically-pure 7-(2′-trimethylsilyl)ethyl camptothecin
发明人：CHEN XINGHAI; HAUSHEER FREDERICK H; MALAKHOV ANDREY; KOCHAT HARRY
权利人:CHEN XINGHAI; HAUSHEER FREDERICK H; MALAKHOV ANDREY; KOCHAT HARRY; BIONUMERIK PHARMACEUTICALS INC
摘要:The present invention discloses and claims five (5) novel, highly efficient synthetic routes for the total synthesis of enantiomerically-pure (i.e., 99%) 7-(2′-trimethylsilyl)ethyl camptothecin (BNP1350; Karenitecin; Cositecan). These aforementioned synthetic schemes are the first to disclose the total syntheses of 7-(2′-trimethylsilyl)ethyl camptothecin using a highly novel direct, non-linear and convergent synthetic strategy which involves annealing the key C7-(trimethylsilyl)ethyl side chain-bearing A ring key synthons to an enantiomerically-pure tricyclic pyridone; rather than through the conventional methodology which incorporates the C7-(trimethylsilyl)ethyl side chain as the final synthetic step on a totally synthesized camptothecin parent compound. The current novel synthetic approaches reported herein since utilize desirably functionalized A-ring with preinstalled trimethyl silyl ethyl side chain, the aforementioned synthetic methodologies have a wider scope of making wide range of pharmaceutically relevant A-ring substituted BNP1350 analogs by substituting desirably functionalized nitro or protected amino phenyl carboxy A-ring as the starting material.

专利号:US-9944532-B2
优先权日:2013-10-22
标 题 :Solid source and method for the synthesis of silicon-containing precursors for chemical vapor deposition
发明人：SCARLETE MIHAI; AKTIK CETIN
权利人:SOCPRA SCIENCE ET GENIE S E C; UNIV DE BISHOP; SOCPRA SCIENCE ET GENIE S E C
摘要:The present document described a solid source and a method for synthesis of silicon-containing precursors for chemical vapor deposition. The solid source comprises a solid polysilane; an energy coupling agent distributed in the solid polysilane; and hydrogen, mixed with the solid polysilane and the energy coupling agent distributed in the solid polysilane, in a necessary amount to satisfy a hydrogen deficiency during a hydrogenolysis reaction.