📜苯酚置于硫酸,硝酸体系中,化学反应生成洛克沙砷 参考文献:Conant,Journal Of The American Chemical Society,1919,Vol. 41,P. 432 标题:Conant,Journal Of The American Chemical Society,1919,Vol. 41,P. 432
专利号:US-3974110-A 优先权日:1973-10-04 标题:Modification of polystyrene by Friedel-Crafts reaction with substituted halo ethyl benzenes and haloethylphenols to make supports for solid phase peptide synthesis 发明人:PATCHORNIK ABRAHAM; KALIR RAMI; FRIDKIN MATITYAHU; WARSHAVSKY ABRAHAM 权利人:YEDA RES & DEV 摘要:A process for producing reagents useful in organic synthesis, of the general formula WHEREIN Z designates the (CH2-CH-CH2-) ¦ part of a polymeric backbone of a polymer like polystyrene, a copolymer comprising polystyrene and a comonomer like divinylbenzene, butadiene, and other copolymers comprising styrene, or wherein Z designates the aliphatic moiety of a long-chain aralkyl compound having a terminal phenyl moiety; N IS AN INTEGER FROM 1 TO 8, INCLUSIVE; R designates oxygen or sulfur; X designates nitro, carbonyl, carboxyl, cyano-carbalkoxy or a carboxamido group which may be substituted on the nitrogen atom, or a halogen atom, or alkyl, unsaturated alkyl, aralkyl; RH and X together designate hydroxytriazole; which comprises reacting a compound of the general formula WHEREIN Y designates -Cl, -Br, or -OH and X and R are as defined above, with a polystyrene polymer or with a copolymer as defined above, or with a long-chain araliphatic compound as defined above, in a Friedel-Crafts reaction. According to a preferred embodiment copolymers of polystyrene and divinylbenzene are used. The invention also relates to the novel products obtained by the above reaction.
专利号:US-9693999-B2 优先权日:2011-01-26 标题:Small molecule RNase inhibitors and methods of use 发明人:DUNMAN PAUL M; OLSON PATRICK D; CHILDERS WAYNE 权利人:UNIV ROCHESTER; UNIV NEBRASKA; Temple University—Of the Commonwealth System of Higher Education 摘要:Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.
专利号:US-9768333-B2 优先权日:2009-02-03 标题:Microbially-mediated method for synthesis of non-oxide semiconductor nanoparticles 发明人:PHELPS TOMMY J; LAUF ROBERT J; MOON JI-WON; RONDINONE ADAM JUSTIN; LOVE LONNIE J; DUTY CHAD EDWARD; MADDEN ANDREW STEPHEN; LI YILIANG; IVANOV ILIA N; RAWN CLAUDIA JEANETTE 权利人:UT BATTELLE LLC; UNIV TENNESSEE RES FOUND 摘要:The invention is directed to a method for producing non-oxide semiconductor nanoparticles, the method comprising: (a) subjecting a combination of reaction components to conditions conducive to microbially-mediated formation of non-oxide semiconductor nanoparticles, wherein said combination of reaction components comprises i) anaerobic microbes, ii) a culture medium suitable for sustaining said anaerobic microbes, iii) a metal component comprising at least one type of metal ion, iv) a non-metal component comprising at least one non-metal selected from the group consisting of S, Se, Te, and As, and v) one or more electron donors that provide donatable electrons to said anaerobic microbes during consumption of the electron donor by said anaerobic microbes; and (b) isolating said non-oxide semiconductor nanoparticles, which contain at least one of said metal ions and at least one of said non-metals. The invention is also directed to non-oxide semiconductor nanoparticle compositions produced as above and having distinctive properties.
专利号:US-5352587-A 优先权日:1989-06-23 标 题:Compositions and methods for the synthesis of natriuretic protein receptor B and methods of use 发明人:CHANG MING-SHI; GOEDDEL DAVID V; LOWE DAVID G 权利人:GENENTECH INC 摘要:PCT No. PCT/US90/03586 Sec. 371 Date Dec. 19, 1991 Sec. 102(e) Date Dec. 19, 1991 PCT Filed Jun. 22, 1990 PCT Pub. No. WO91/00292 PCT Pub. Date Jan. 10, 1991.Described are the amino acid sequence of natriuretic peptide receptor B (NPRB) and DNA encoding NPRB. Also disclosed are expression vectors and cells transformed to express the NPRB, DNA encoding NPRB and diagnostic and therapeutic uses for the NPRB and the DNA encoding NPRB.
专利号:US-8759053-B2 优先权日:2009-02-03 标 题 :Microbially-mediated method for synthesis of non-oxide semiconductor nanoparticles 发明人:PHELPS TOMMY J; LAUF ROBERT J; MOON JI WON; RONDINONE ADAM J; LOVE LONNIE J; DUTY CHAD EDWARD; MADDEN ANDREW STEPHEN; LI YILIANG; IVANOV ILIA N; RAWN CLAUDIA JEANETTE 权利人:PHELPS TOMMY J; LAUF ROBERT J; MOON JI WON; RONDINONE ADAM J; LOVE LONNIE J; DUTY CHAD EDWARD; MADDEN ANDREW STEPHEN; LI YILIANG; IVANOV ILIA N; RAWN CLAUDIA JEANETTE; UT BATTELLE LLC; UNIV TENNESSEE RES FOUNDATION 摘要:The invention is directed to a method for producing non-oxide semiconductor nanoparticles, the method comprising: (a) subjecting a combination of reaction components to conditions conducive to microbially-mediated formation of non-oxide semiconductor nanoparticles, wherein said combination of reaction components comprises i) anaerobic microbes, ii) a culture medium suitable for sustaining said anaerobic microbes, iii) a metal component comprising at least one type of metal ion, iv) a non-metal component containing at least one non-metal selected from the group consisting of S, Se, Te, and As, and v) one or more electron donors that provide donatable electrons to said anaerobic microbes during consumption of the electron donor by said anaerobic microbes; and (b) isolating said non-oxide semiconductor nanoparticles, which contain at least one of said metal ions and at least one of said non-metals. The invention is also directed to non-oxide semiconductor nanoparticle compositions produced as above and having distinctive properties.
专利号:US-3573253-A 优先权日:1968-11-18 标题:Preparation of cross-linked poly (4-hydroxy - 3 - nitro) (nonsubstituted or alpha and/or beta substituted) stryene 发明人:GRAY DON N 权利人:DON N GRAY 摘要:THERE IS DISCLOSED A PROCESS FOR PREPARING A SOLID PHASE, POLYMERIC SUBSTRATE COMPRISING A CROSS-LINKED POLY (4HYDROXY-3-NITRO) STYRENE WHICH IS ESPECIALLY SUITABLE FOR THE SYNTHESIS OF POLYPEPTIDES. THE POLYSTYRENE MAY BE NONSUBSTITUTED OR SUBSTITUTED (ALPHA AND/OR BETA).
1: Liu QH, Yuan L, Li ZH, Leung KMY, Sheng GP. Environmental co-exposure to roxarsone and heavy metals drives bacterial antibiotic multidrug resistance via genetic and phenotypic adaptations. Water Res. 2026 Jan 1;288(Pt B):124682. doi: 10.1016/j.watres.2025.124682. Epub 2025 Sep 29. 284:122173. doi: 10.1016/j.envres.2025.122173. Epub 2025 Jun 19. 482:144168. doi: 10.1016/j.foodchem.2025.144168. Epub 2025 Mar 31. 25(1):23. doi: 10.1186/s12866-024-03740-4.
合成参考文献
摘要:Toxicology and Applied Pharmacology., 5(507), 1963 [] 摘要:National Toxicology Program Technical Report Series., NTP-TR-345(1989) 摘要:L20: Wikipedia. Arsenic toxicity. Last Updated 22 February 2009. 摘要:A17: Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. doi: 10.1016/j.jinorgbio.2007.10.021. Epub 2007 Nov 22.