CAS: 121-19-7; Roxarsone

该化合物是黄色晶状固体,因其抗微生物特性而闻名.Roxarsonone在水中溶解,与其他砷化合物相比毒性较低,尽管人们对它有可能在环境中转化为毒性较大的砷形式表示关切,但其化学结构包括一种砷原子结为芳香环,有助于其生物活动.该化合物已受到审查,以了解其环境影响,特别是动物产品的砷积累和潜在的人类健康风险.监管机构已评估其安全性,导致某些地区的限制.总的来说,虽然Roxorsonone在农业应用中有效,但由于与砷接触有关的环境和健康问题,其使用正日益受到重新考虑.

结构式图片

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

(4-chloro-3-nitro-phenyl)-arsonic acid 4-hydroxyphenylarsonic acid (4-bromo-3-nitro-phenyl)-arsonic acid (4-iodo-3-nitro-phenyl)-arsonic acid4-iodo-2-nitrophenol 3-amino-4-hydroxyphenylarsonic acid 4-Arsenoso-2-nitro-phenol 4-methoxy-3-nitrophenylarsonic acid

合成工艺路线路线简述

    📜苯酚置于硫酸,硝酸体系中,化学反应生成洛克沙砷
    参考文献:Conant,Journal Of The American Chemical Society,1919,Vol. 41,P. 432
    标题:Conant,Journal Of The American Chemical Society,1919,Vol. 41,P. 432

    海关参考信息

    专利信息


    专利号:US-3974110-A
    优先权日:1973-10-04
    标题:Modification of polystyrene by Friedel-Crafts reaction with substituted halo ethyl benzenes and haloethylphenols to make supports for solid phase peptide synthesis
    发明人:PATCHORNIK ABRAHAM; KALIR RAMI; FRIDKIN MATITYAHU; WARSHAVSKY ABRAHAM
    权利人:YEDA RES & DEV
    摘要:A process for producing reagents useful in organic synthesis, of the general formula WHEREIN Z designates the (CH2-CH-CH2-) ¦ part of a polymeric backbone of a polymer like polystyrene, a copolymer comprising polystyrene and a comonomer like divinylbenzene, butadiene, and other copolymers comprising styrene, or wherein Z designates the aliphatic moiety of a long-chain aralkyl compound having a terminal phenyl moiety; N IS AN INTEGER FROM 1 TO 8, INCLUSIVE; R designates oxygen or sulfur; X designates nitro, carbonyl, carboxyl, cyano-carbalkoxy or a carboxamido group which may be substituted on the nitrogen atom, or a halogen atom, or alkyl, unsaturated alkyl, aralkyl; RH and X together designate hydroxytriazole; which comprises reacting a compound of the general formula WHEREIN Y designates -Cl, -Br, or -OH and X and R are as defined above, with a polystyrene polymer or with a copolymer as defined above, or with a long-chain araliphatic compound as defined above, in a Friedel-Crafts reaction. According to a preferred embodiment copolymers of polystyrene and divinylbenzene are used. The invention also relates to the novel products obtained by the above reaction.

    专利号:US-9693999-B2
    优先权日:2011-01-26
    标题:Small molecule RNase inhibitors and methods of use
    发明人:DUNMAN PAUL M; OLSON PATRICK D; CHILDERS WAYNE
    权利人:UNIV ROCHESTER; UNIV NEBRASKA; Temple University—Of the Commonwealth System of Higher Education
    摘要:Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.

    专利号:US-9768333-B2
    优先权日:2009-02-03
    标题:Microbially-mediated method for synthesis of non-oxide semiconductor nanoparticles
    发明人:PHELPS TOMMY J; LAUF ROBERT J; MOON JI-WON; RONDINONE ADAM JUSTIN; LOVE LONNIE J; DUTY CHAD EDWARD; MADDEN ANDREW STEPHEN; LI YILIANG; IVANOV ILIA N; RAWN CLAUDIA JEANETTE
    权利人:UT BATTELLE LLC; UNIV TENNESSEE RES FOUND
    摘要:The invention is directed to a method for producing non-oxide semiconductor nanoparticles, the method comprising: (a) subjecting a combination of reaction components to conditions conducive to microbially-mediated formation of non-oxide semiconductor nanoparticles, wherein said combination of reaction components comprises i) anaerobic microbes, ii) a culture medium suitable for sustaining said anaerobic microbes, iii) a metal component comprising at least one type of metal ion, iv) a non-metal component comprising at least one non-metal selected from the group consisting of S, Se, Te, and As, and v) one or more electron donors that provide donatable electrons to said anaerobic microbes during consumption of the electron donor by said anaerobic microbes; and (b) isolating said non-oxide semiconductor nanoparticles, which contain at least one of said metal ions and at least one of said non-metals. The invention is also directed to non-oxide semiconductor nanoparticle compositions produced as above and having distinctive properties.

    专利号:US-5352587-A
    优先权日:1989-06-23
    标 题:Compositions and methods for the synthesis of natriuretic protein receptor B and methods of use
    发明人:CHANG MING-SHI; GOEDDEL DAVID V; LOWE DAVID G
    权利人:GENENTECH INC
    摘要:PCT No. PCT/US90/03586 Sec. 371 Date Dec. 19, 1991 Sec. 102(e) Date Dec. 19, 1991 PCT Filed Jun. 22, 1990 PCT Pub. No. WO91/00292 PCT Pub. Date Jan. 10, 1991.Described are the amino acid sequence of natriuretic peptide receptor B (NPRB) and DNA encoding NPRB. Also disclosed are expression vectors and cells transformed to express the NPRB, DNA encoding NPRB and diagnostic and therapeutic uses for the NPRB and the DNA encoding NPRB.

    专利号:US-8759053-B2
    优先权日:2009-02-03
    标 题 :Microbially-mediated method for synthesis of non-oxide semiconductor nanoparticles
    发明人:PHELPS TOMMY J; LAUF ROBERT J; MOON JI WON; RONDINONE ADAM J; LOVE LONNIE J; DUTY CHAD EDWARD; MADDEN ANDREW STEPHEN; LI YILIANG; IVANOV ILIA N; RAWN CLAUDIA JEANETTE
    权利人:PHELPS TOMMY J; LAUF ROBERT J; MOON JI WON; RONDINONE ADAM J; LOVE LONNIE J; DUTY CHAD EDWARD; MADDEN ANDREW STEPHEN; LI YILIANG; IVANOV ILIA N; RAWN CLAUDIA JEANETTE; UT BATTELLE LLC; UNIV TENNESSEE RES FOUNDATION
    摘要:The invention is directed to a method for producing non-oxide semiconductor nanoparticles, the method comprising: (a) subjecting a combination of reaction components to conditions conducive to microbially-mediated formation of non-oxide semiconductor nanoparticles, wherein said combination of reaction components comprises i) anaerobic microbes, ii) a culture medium suitable for sustaining said anaerobic microbes, iii) a metal component comprising at least one type of metal ion, iv) a non-metal component containing at least one non-metal selected from the group consisting of S, Se, Te, and As, and v) one or more electron donors that provide donatable electrons to said anaerobic microbes during consumption of the electron donor by said anaerobic microbes; and (b) isolating said non-oxide semiconductor nanoparticles, which contain at least one of said metal ions and at least one of said non-metals. The invention is also directed to non-oxide semiconductor nanoparticle compositions produced as above and having distinctive properties.

    专利号:US-3573253-A
    优先权日:1968-11-18
    标题:Preparation of cross-linked poly (4-hydroxy - 3 - nitro) (nonsubstituted or alpha and/or beta substituted) stryene
    发明人:GRAY DON N
    权利人:DON N GRAY
    摘要:THERE IS DISCLOSED A PROCESS FOR PREPARING A SOLID PHASE, POLYMERIC SUBSTRATE COMPRISING A CROSS-LINKED POLY (4HYDROXY-3-NITRO) STYRENE WHICH IS ESPECIALLY SUITABLE FOR THE SYNTHESIS OF POLYPEPTIDES. THE POLYSTYRENE MAY BE NONSUBSTITUTED OR SUBSTITUTED (ALPHA AND/OR BETA).

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Liu QH, Yuan L, Li ZH, Leung KMY, Sheng GP. Environmental co-exposure to roxarsone and heavy metals drives bacterial antibiotic multidrug resistance via genetic and phenotypic adaptations. Water Res. 2026 Jan 1;288(Pt B):124682. doi: 10.1016/j.watres.2025.124682. Epub 2025 Sep 29.
    284:122173. doi: 10.1016/j.envres.2025.122173. Epub 2025 Jun 19.
    482:144168. doi: 10.1016/j.foodchem.2025.144168. Epub 2025 Mar 31. 25(1):23. doi: 10.1186/s12866-024-03740-4.

    合成参考文献


    摘要:Toxicology and Applied Pharmacology., 5(507), 1963 []
    摘要:National Toxicology Program Technical Report Series., NTP-TR-345(1989)
    摘要:L20: Wikipedia. Arsenic toxicity. Last Updated 22 February 2009.
    摘要:A17: Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. doi: 10.1016/j.jinorgbio.2007.10.021. Epub 2007 Nov 22.
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