CAS: 134-35-0; (2S)-2-(4-(((2-Amino-5-Methyl-4-Oxo-3,4,5,6,7,8-Hexahydropteridin-6-yl)Methyl)Amino)Benzamido)Pentanedioic Acid

专利信息

专利号:WO-9317112-A1
优先权日:1992-02-20
标题:Biosynthesis of methionine using a reduced source of sulfur
发明人：LIEVENSE JEFFERSON CLAY
权利人:GENENCOR INT
摘要:There are provided methods for the fermentation synthesis of methionine and homoserine using a reduced source of sulfur such as sulfide or methylmercaptan; and/or by modifying the methionine biosynthetic pathway in a producing microbe. Also provided are methods for the fermentation synthesis of methionine and homoserine using an oxidized sulfur source such as sulfate, sulfite or thiosulfate; and/or by modifying the methionine biosynthetic pathway in a producing microbe.

专利号:US-7635764-B2
优先权日:1997-11-24
标题:Nucleic acid molecules associated with the methionine synthesis and degradation pathways
发明人：BLEDIG STEFAN A; BYRUM JOSEPH R; LIU JINGDONG
权利人:MONSANTO TECHNOLOGY LLC
摘要:The present invention is in the field of plant biochemistry. More specifically the invention relates to nucleic acid sequences from plant cells, in particular, DNA sequences from maize and soybean plants associated with the methionine pathway. The invention encompasses nucleic acid molecules that encode proteins and fragments of proteins. In addition, the invention also encompasses proteins and fragments of proteins so encoded and antibodies capable of binding these proteins or fragments. The invention also relates to methods of using the nucleic acid molecules, proteins and fragments of proteins and antibodies, for example for genome mapping, gene identification and analysis, plant breeding, preparation of constructs for use in plant gene expression and transgenic plants.

专利号:US-2015317458-A1
优先权日:2012-12-06
标 题 :In silico prediction of enhanced nutrient content in plants by metabolic modelling
发明人：LOTZ KATRIN; LEPS MICHAEL; LEMKE RAINER; JUNKER BJOERN; SCHREIBER FALK
权利人:BASF PLANT SCIENCE CO GMBH
摘要:The present invention relates to a method for identifying at least one metabolic conversion step, the modulation of which increases the amount of a metabolite of interest in a plant cell, plant or plant part, said method comprising establishing a stoichiometric network model for the metabolism of the plant cell, plant or plant part including the synthesis pathway for the metabolite of interest, identifying at least one candidate metabolic conversion step by applying at least one algorithm of Growth-coupled Design, and validating the at least one candidate metabolic conversion step by a constraint-based modeling approach in the stoichiometric network model, wherein an increase in the metabolite of interest occurring in said constraint-based modeling approach is indicative for a metabolic conversion step, the modulation of which increases the amount of the metabolite of interest in the plant cell, plant or plant part. The present invention further relates to a method for generating a plant cell, plant or plant part which produces an increased amount of a metabolite of interest when compared to a control, said method comprising identifying a metabolic conversion step, the modulation of which increases a metabolite of interest in a plant cell, plant or plant part, by the method for identifying a metabolic conversion step and modulating the said metabolic conversion step such that the amount of the metabolite of interest is increased in vivo in a plant cell, plant or plant part.

专利号:US-8389535-B2
优先权日:2010-07-01
标题 :L-methylfolate treatment for psychiatric or neurologic disorders
发明人：QUILLIN ROBERT L
权利人:QUILLIN ROBERT L
摘要:Provided herein are methods of treating neuropsychiatric disorders or improving the symptoms associated therewith administering a medical food, such as L-methylfolate, to a subject having the disorder. The neuropsychiatric disorder may be an autism spectrum disorder or attention deficit disorder with or without hyperactivity (ADD/ADHD). The L-methylfolate may be administered as an adjunct to other therapeutic agents effective to treat the disorder. The subject preferably may be a child and also may have a single nucleotide polymorphism in the MTHFR gene associated with reduced expression of MTHFR enzyme. Also provided is a method of increasing the de novo synthesis of neurotransmitters in vivo by transporting a methyl-donating compound across the blood-brain barrier in a subject.

专利号:US-2007190596-A1
优先权日:2006-01-20
标题:Synthesis of (6S)-5-methyl-5,6,7,8-tetrahydrofolic acid

专利号:EP-4524234-A1
优先权日:2023-09-14
标题 :Genetically engineered bacterium using glucose as substrate for de novo synthesis of vanillin and application thereof