CAS: 7084-24-4; 2-(3,4-Dihydroxyphenyl)-5,7-Dihydroxy-3-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Chromenylium Chloride

该化合物是对其生物活性特性进行广泛研究的一种炭疽衍生物. 这种水溶色色显示出强烈的抗氧化性活动,在氧化压力和细胞保护的研究应用中具有价值. 其稳定的氯化物形式比其他炭氰胺剂更能溶解和生物利用率. 氯甲烷因其潜在的反炎和代谢效益,通常用于营养,制药和食品科学研究. 化合物的特征精密结构和高纯度(典型为 95 %) 保证实验环境中的再生性. 它与其他水分和极有机溶剂的兼容性进一步促进了体外生和体外生研究.

结构式图片

上下游产品

CAS号32292-78-7 2-(苯甲酰氧基)-4,6-二羟基苯甲醛 | CAS号99-50-3 原儿茶酸 | CAS号487-70-7 2,4,6-三羟基苯甲醛

合成工艺路线路线简述

    (2S,3R,4S,5R,6R)-2-[(2S,3R,4S,5S,6R)-2-[2-(3,4-Dihydroxyphenyl)-5,7-Dihydroxychromenylium-3-Yl]Oxy-4,5-Dihydroxy-6-(Hydroxymethyl)Oxan-3-Yl]Oxy-6-Methyloxane-3,4,5-Triol;Chloride 反应生成 矢车菊素-3-O-葡萄糖苷
    参考文献:Andersen,Zhiametryvind M.,Phytochemistry,28,(1989) N,C. 495-497
    标题:Andersen,Zhiametryvind M.,Phytochemistry,28,(1989) N,C. 495-497

    海关参考信息

    专利信息


    专利号:US-2023119068-A1
    优先权日:2020-02-13
    标题:Methods for rapid synthesis of pyranoanthocyanins
    发明人:ZHU XIAOYI; STRAATHOF NICOLE; MIYAGUSUKU-CRUZADO GONZALO; GIUSTI M MONICA; CANO ISRAEL GARCIA; JIMENEZ-FLORES RAFAEL
    权利人:OHIO STATE INNOVATION FOUNDATION
    摘要:The present disclosure provides methods for the rapid synthesis of pyranoanthocyanins.

    专利号:WO-2025081225-A1
    优先权日:2023-10-17
    标 题 :Synthesis of polyphenols
    发明人:TURLAND CADE LACHLAN; GROLMAN DAVID; BEHRENDORFF JAMES BRUCE YARNTON HAYCOCK; MORADI SHAYLI VARASTEH; THOMSON RAINE ELIZABETH STURT
    权利人:Delica Therapeutics Pty Ltd
    摘要:The present disclosure relates to polyphenols, including flavonoids, flavones and cannflavins, and methods of synthesising polyphenols. The present disclosure provides methods, enzymes and compositions that may be useful in the synthesis of polyphenols.

    专利号:US-2024009104-A1
    优先权日:2021-02-09
    标 题:Process for extraction and hemi-synthesis of pyranoanthocyanins and skincare cosmetic formulations containing them
    发明人:REIS FERNANDES IVA LUZIA; DA SILVA OLIVEIRA PINTO DA SILVA JOANA ALEXANDRA; DA CRUZ BATISTA MATEUS NUNO FILIPE; PEREIRA DE FREITAS VICTOR ARMANDO; COUTO OLIVEIRA HELDER JOSÉ; CARNEIRO ARAUJO PAULA ALEXANDRA; RODRIGUES CORREIA PATRICIA; MARTINS PEREIRA ANA RITA
    权利人:UNIV DO PORTO; REQUIMTE REDE DE QUIM E TECNOLOGIA
    摘要:A process of extraction of anthocyanins from different foodstuffs or by-products, and their conversion into pyranoanthocyanins compounds, which can be used as pigments having new colors and improved stability to be incorporated into skincare formulations in particular anti-ageing and sun-protection formulations. Cosmetic formulations having the pigments with improved properties of UV protection and moisturizing, anti-dark spots, anti-wrinkles and wound-healing, which can be associated with interesting colors ranging from red to blue depending on the selected pigments in the composition and in the formula composition. The present invention is in the area of organic chemistry, biochemistry, pharmacology and cosmetics for skincare.

    专利号:US-2024026314-A1
    优先权日:2020-11-25
    标题 :Polypeptides for use in the synthesis of bioactive phenolic compounds
    发明人:ROTHSTEIN STEVEN; AKHTAR TARIQ; CASARETTO JOSE; PERRIN COLBY; VAN GELDER KRISTEN
    权利人:ROTHSTEIN STEVEN; AKHTAR TARIQ; CASARETTO JOSE; PERRIN COLBY; VAN GELDER KRISTEN
    摘要:Described herein is a polypeptide encoding a prenyltransferase for prenylating a polyphenol and a polypeptide encoding an O-methyltransferase for methylating a polyphenol. For example, the polypeptide comprises or consists of the sequence of SEQ ID NO: 1, 2, 3, 4, 5, and/or 6, and/or a polypeptide listed in Table 1, and/or SEQ ID NO: 7-30, or a variant thereof having at least 80% sequence identity to SEQ ID NO: 1, 2, 3, 4, 5, and/or 6, and/or the polypeptide listed in Table 1, and/or SEQ ID NO: 7-30, or a fragment of the polypeptide or the variant thereof.

    专利号:US-8513395-B2
    优先权日:2005-06-15
    标题:Method for the synthesis of anthocyanins
    发明人:BAKSTAD EINAR
    权利人:BAKSTAD EINAR; BIOSYNTH AS
    摘要:The present invention relates to methods of preparing anthocyanins, and methods of preparing precursors of anthocyanins. The methods utilize a coupling reaction between a sugar and a suitable electrophilic precursor to form Eastern half intermediates that are then reacted with Western half intermediates to form the target anthocyanins. Some Eastern half intermediates and electrophilic precursors also form part of the invention.

    专利号:US-2007232495-A1
    优先权日:2006-03-24
    标题:Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof
    发明人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
    权利人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
    摘要:The invention is related to compositions and methods that naturally protect plant tissues against ultraviolet radiation and temperature, thus giving protection against sunburn to plants, plant parts, fruits and/or flowers during their development. The invention is also related to compositions and methods to naturally improve the color of plants, plant parts, fruits and/or flowers by inducing the natural synthesis of flavonoids and anthocyanins present in plants. Likewise, the present invention is directed to improving the nutritional value of plants, plant parts, fruits and/or flowers by increasing the normal levels of polyphenolic compounds, especially flavonoids, present therein. Additionally, the present invention is related to compositions and methods that give more resistance to plants, plant parts, fruits and/or flowers against pathogens as bacteria and fungi. Finally, the present invention is related to plants, plant parts, fruits, flowers and/or propagating material treated with the compositions described in the present document.
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    主要参考文献


    1: Ndiaye A, Dioum A, Oprea CI, Dumbrava A, Lungu J, Georgescu A, Moscalu F, Gîrţu MA, Beye AC, Youm I. A Combined Experimental and Computational Study of Chrysanthemin as a Pigment for Dye-Sensitized Solar Cells. Molecules. 2021 Jan 4;26(1):225. doi: 10.3390/molecules26010225.
    2: Sun DK, Wang L, Zhang P. ANTITUMOR EFFECTS OF CHRYSANTHEMIN IN PC-3 HUMAN PROSTATE CANCER CELLS ARE MEDIATED VIA APOPTOSIS INDUCTION, CASPASE SIGNALLING PATHWAY AND LOSS OF MITOCHONDRIAL MEMBRANE POTENTIAL. Afr J Tradit Complement Altern Med. 2017 Jun 5;14(4):54-61. doi: 10.21010/ajtcam.v14i4.7.
    3: Soto-Rojo R, Baldenebro-López J, Flores-Holguín N, Glossman-Mitnik D. Comparison of several protocols for the computational prediction of the maximum absorption wavelength of chrysanthemin. J Mol Model. 2014 Aug;20(8):2378. doi: 10.1007/s00894-014-2378-2. Epub 2014 Jul 25. 20(9):2348. doi: 10.3390/ijms20092348.

    合成参考文献


    参考文献:10.1186/s12957-021-02339-7
    摘要:Chen X, Zhang W, Xu X. Cyanidin-3-glucoside suppresses the progression of lung adenocarcinoma by downregulating TP53I3 and inhibiting PI3K/AKT/mTOR pathway. World Journal of Surgical Oncology. 2021 Aug 06;19(1):232. doi: 10.1186/s12957-021-02339-7.
    摘要:United States Patent Document., #4229439
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