CAS: 865-47-4; Potassium Tert-Butanolate

• 英文名称Potassium Tert-Butanolate
• 中文名称叔丁醇钾
• 其它别名Potassium tert-butylate; Potassium tert-butoxide; KtB
• CAS编号865-47-4
• MFCD编号:MFCD00012162
• EINECS号:212-740-3
• FDA UNII编号:VR838VHE0V
• 分子式:C4H9KOLewis structure
• 分子量:112.21
• 产品CID: 1867908
• 产品分类有机原料 → 有机金属类化合物 → 有机钾

• 相似结构搜索
• 产品信息参考
• InChIKey: LPNYRYFBWFDTMA-UHFFFAOYSA-N
• InChI=1S/C4H9O.K/c1-4(2,3)5;/h1-3H3;/q-1;+1…
• 计算化学: 氢键受体数1.0氢键供体数1.0可旋转键数0.0

物理性质

• 熔点256-258  °C (分解)(文献)
• 沸点275 °C
• 闪点54 °F
• 密度0.910 g/mL at 20 °C
• PH:13 (5g/l, H2O, 20°C)Hydrolysis
• pKa:pK1:18(25°C)
• PSA:23.06
• LogP:1.2154
• 蒸汽压1 mm Hg ( 220 °C)
• 溶解性Soluble In Hexane, Toluene, Diethyl Ether And Terahydrofuran.
• 敏感性易受潮
• 外观形态白色至类白色溶液
• 储存条件存储低于 +30°C.
• 产品应用丁醇钾在有机化学中用途广泛,因为它是一种非亲核性强碱.它的碱性没有氨基碱强,例如二异丙氨基锂(简称LDA),但比氢氧化钾强得多.叔丁基较大的空间位阻影响了它参与亲核取代反应,例如威廉姆逊合成或SN2.叔丁醇钾能从许多有机物中夺取质子,例如末端炔烃和活泼亚甲基化合物.它在卤代烃脱去卤化氢形成烯烃的β-消除反应中也很常用. 用于农药,医药,印染,催化剂等.广泛应用于化工,医药,农药等有机合成中的缩合,重排和开环等反应中.
• 性质描述常温下为白色或类白色固体粉末,密度0.929,熔点256-258°C,沸点275°C,与水反应.叔丁醇钾碱性强而亲核性相对较弱,溶于THF,常用于卤代烃的脱卤化氢反应.本品是有机碱性腐蚀品,强吸湿,应密封保存,在贮运中注意防火,防晒以及要存放在阴凉通风干燥处.可挤压干燥. 易吸湿.溶于叔丁醇,常用于卤代烃的脱卤化氢反应,其溶液较稳定.暴露于空气中分解.遇水分解成氢氧化钾与叔丁醇.可由叔丁醇与金属钾反应后,减压蒸去叔丁醇制得.强碱性缩合剂,其碱性较甲醇钠,乙醇钠强.广泛用于有机合成的缩合,重排和开环等反应中,一般用叔丁醇溶液.

MSDS等安全信息

• GHS象形图
• GHS符号GHS02 & GHS05;
  注释: Flame & Corrosion
• 危险类别易燃固体 类别1
  自热物质 类别2
  皮肤腐蚀 类别1A
  Self-heat. 1
  严重眼损伤 类别1
  急性毒性 类别4(经口)
  皮肤腐蚀 类别1B
  易燃固体 类别2
  Water-react. 3
  皮肤腐蚀 类别1C
  易燃液体 类别2
  Water-react. 2
• 警示词Danger(危险)
• 危险描述H228 |易燃固体.
  H252 |大量自热;可能着火.
  H314 |造成严重皮肤灼伤和眼损伤.
  H251 |自热:可能起火.
  H318 |造成严重眼损伤.
  H302 |吞咽有害.
  H261 |遇水放出易燃气体.
  H225 |高度易燃液体和蒸气.
• 防范说明P210-P231+P232-P260-P280-P303+P361+P353-P305+P351+P338
• 危险等级8
• UN编号UN 3274 3/PG 2
• 危险品标志F,C,Xi
• 风险等级Flammable solid/Corrosive
• 包装等级I
• 安全声明16-26-36/37/39-43-45-7/9-8-43A-33-27-29
• 危险类别码11-19-22-34-35-14-20-36/37-37
• WGK Germany1

欧盟法规

上下游产品

合成工艺路线路线简述

• 合成目标产物 Potassium Tert-Butoxide 主要起始原料 Tert-Butanol
• 113-00-8 = 865-47-4 [标题:Reaction Conditions
  标题:Preparation Of N-[4-[3-(2-Aminopyrido[2,3-D]Pyrimidin-6-Yl)Propyl]Benzoyl]Glutamates And Analogs As Antitumor Agents
  参考文献:European Patent Organization]
  
  113-00-8 = 865-47-4 [标题:Reaction Conditions
  标题:Preparation Of N-[4-[3-(2-Aminopyrido[2,3-D]Pyrimidin-6-Yl)Propyl]Benzoyl]Glutamates And Analogs As Antitumor Agents
  参考文献:European Patent Organization]
  
  105-56-6 = 865-47-4 [标题:Reaction Conditions
  标题:Preparation Of N-[4-[3-(2-Aminopyrido[2,3-D]Pyrimidin-6-Yl)Propyl]Benzoyl]Glutamates And Analogs As Antitumor Agents
  参考文献:European Patent Organization]
  
  = 865-47-4
  反应条件:1.1 Reagents: Sodium Hydride Solvents: Dimethyl Sulfoxide2.1 -
  标题:Preparation Of N-[4-[3-(2-Aminopyrido[2,3-D]Pyrimidin-6-Yl)Propyl]Benzoyl]Glutamates And Analogs As Antitumor Agents
  参考文献:European Patent Organization]
  
  = 865-47-4
  反应条件:1.1 Catalysts: Oxalyl Chloride2.1 -
  标题:Preparation Of N-[4-[3-(2-Aminopyrido[2,3-D]Pyrimidin-6-Yl)Propyl]Benzoyl]Glutamates And Analogs As Antitumor Agents
  参考文献:European Patent Organization]
  
  = 865-47-4
  反应条件:1.1 -2.1 Catalysts: Acetamide
  标题:Structural Modifications Of The Potassium Channel Activator Cromakalim: The C-3 Position
  作者:Buckle,Derek R.; Et Al
  参考文献:Journal Of The Chemical Society 日期:1991 卷标:(1) 页码:63-72]
  
  = 865-47-4
  反应条件:1.1 Solvents: Ethanol2.1 Catalysts: Oxalyl Chloride3.1 -
  标题:Preparation Of N-[4-[3-(2-Aminopyrido[2,3-D]Pyrimidin-6-Yl)Propyl]Benzoyl]Glutamates And Analogs As Antitumor Agents
  参考文献:European Patent Organization]
  
  = 865-47-4
  反应条件:1.1 Reagents: Potassium; 50 °C
  标题:A Practical Synthesis Of (Z)- And (E)-8-Dodecene-1-Yl Acetate,Components Of Lepidoptera Insect Sex Pheromones
  作者:Ciotlaus,Irina; Et Al
  参考文献:Revista De Chimie (Bucharest 日期:2017 卷标:68(1) 页码:157-162]
  
  = 865-47-4
  反应条件:1.1 Solvents: Acetonitrile,Water
  标题:Structurally Simple Benzyl-Type Photolabile Protecting Groups For Direct Release Of Alcohols And Carboxylic Acids
  作者:Wang,Pengfei; Et Al
  参考文献:Organic Letters 日期:2015 卷标:17(9) 页码:2114-2117]
  
  113-00-8 = 865-47-4 [标题:Reaction Conditions
  标题:Preparation Of N-[4-[3-(2-Aminopyrido[2,3-D]Pyrimidin-6-Yl)Propyl]Benzoyl]Glutamates And Analogs As Antitumor Agents
  参考文献:European Patent Organization]
  
  113-00-8 = 865-47-4 [标题:Reaction Conditions
  标题:Preparation Of N-[4-[3-(2-Aminopyrido[2,3-D]Pyrimidin-6-Yl)Propyl]Benzoyl]Glutamates And Analogs As Antitumor Agents
  参考文献:European Patent Organization]
  
  113-00-8 = 865-47-4 [标题:Reaction Conditions
  标题:Preparation Of N-[4-[3-(2-Aminopyrido[2,3-D]Pyrimidin-6-Yl)Propyl]Benzoyl]Glutamates And Analogs As Antitumor Agents
  参考文献:European Patent Organization]
  
  = 865-47-4
  反应条件:1.1 Catalysts: Acetamide
  标题:Structural Modifications Of The Potassium Channel Activator Cromakalim: The C-3 Position
  作者:Buckle,Derek R.; Et Al
  参考文献:Journal Of The Chemical Society 日期:1991 卷标:(1) 页码:63-72]
  
  = 865-47-4
  反应条件:1.1 -2.1 Reagents: Sodium Hydride Solvents: Dimethyl Sulfoxide3.1 -
  标题:Preparation Of N-[4-[3-(2-Aminopyrido[2,3-D]Pyrimidin-6-Yl)Propyl]Benzoyl]Glutamates And Analogs As Antitumor Agents
  参考文献:European Patent Organization]
  
  = 865-47-4 [标题:Reaction Conditions
  标题:Preparation Of N-[4-[3-(2-Aminopyrido[2,3-D]Pyrimidin-6-Yl)Propyl]Benzoyl]Glutamates And Analogs As Antitumor Agents
  参考文献:European Patent Organization]
  
  = 865-47-4
  反应条件:1.1 Solvents: Tetrahydrofuran2.1 -3.1 -4.1 -
  标题:Preparation Of N-[4-[3-(2-Aminopyrido[2,3-D]Pyrimidin-6-Yl)Propyl]Benzoyl]Glutamates And Analogs As Antitumor Agents
  参考文献:European Patent Organization]
  
  = 865-47-4
  反应条件:1.1 -2.1 Solvents: Ethanol3.1 Catalysts: Oxalyl Chloride4.1 -
  标题:Preparation Of N-[4-[3-(2-Aminopyrido[2,3-D]Pyrimidin-6-Yl)Propyl]Benzoyl]Glutamates And Analogs As Antitumor Agents
  参考文献:European Patent Organization]
  
  = 865-47-4
  反应条件:1.1 Reagents: Lithium Borohydride Solvents: Methanol2.1 -3.1 Reagents: Sodium Hydride Solvents: Dimethyl Sulfoxide4.1 -
  标题:Preparation Of N-[4-[3-(2-Aminopyrido[2,3-D]Pyrimidin-6-Yl)Propyl]Benzoyl]Glutamates And Analogs As Antitumor Agents
  参考文献:European Patent Organization

海关参考信息

• 2905122000-异丙醇
  2905143000-叔丁醇
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
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