专利号:WO-2009018504-A1 优先权日:2007-08-01 标题 :Process for the synthesis of diaminopyridine and related compounds 发明人:RITTER JOACHIM C 权利人:DU PONT; RITTER JOACHIM C 摘要:A process is provided for the synthesis of a diaminopyridine, such as 2,6-diaminopyridine and related compounds, which are used industrially as compounds and as components in the synthesis of a variety of useful materials. The synthesis proceeds by means of a chlorine-ammonia displacement in the presence of a copper source.
专利号:US-2025136636-A1 优先权日:2021-08-16 标 题:Nucleotide complexes capable of an improved dna synthesis yield 发明人:KYSH DANIEL; ROTHWELL PAUL 权利人:TOUCHLIGHT IP LTD 摘要:The present invention relates to novel nucleotide complexes which enhance the enzymatic production of DNA. The nucleotide complexes includes a divalent cation at a ratio of 0.2-1.5 divalent cations per nucleotide, whilst monovalent ions (other than hydrogen or hydronium ions from any solvent) are minimal. The nucleotide complexes have desirable properties for the synthesis of deoxyribonucleic acid (DNA), in particular cell-free enzymatic synthesis of DNA, preferably on a large or industrial scale. Further, the invention includes improved processes for preparing said nucleotide complexes. Further complexes are disclosed which possess unique properties in accelerating DNA synthesis at higher concentrations, these complexes also containing zwitterion molecules.
专利号:US-2023091493-A1 优先权日:2020-02-14 标 题:Dna synthesis yield improvements 发明人:ROTHWELL PAUL; KYSH DANIEL; PORTER NEIL 权利人:TOUCHLIGHT IP LTD 摘要:The present invention relates to an improved process for synthesis of deoxyribonucleic acid (DNA), in particular cell-free enzymatic synthesis of DNA, preferably on a large or industrial scale, with an improved yield and/or with an improved efficiency. The invention requires the use of nucleotide complexes wherein the nucleotide is associated with a mixture of divalent and monovalent cations. Preferably, the divalent cation may be magnesium or manganese.
专利号:US-4710566-A 优先权日:1984-12-27 标题:Purification of the messenger RNA cap-binding protein 发明人:KOZARICH JOHN W; RHOADS ROBERT E 权利人:UNIV YALE 摘要:The synthesis of a new affinity medium, the p-aminophenyl-γ-ester of 7-methylguanosine-5'-triphosphate coupled to Sepharose, for use in affinity chromatography is claimed. An improved method in terms of speed and purity for the isolation of messenger ribonucleic acid cap-binding protein is claimed. The synthesis of the p-aminophenyl-γ-ester of 7-methylguanosine-5'-triphosphate is described.
专利号:US-5738855-A 优先权日:1994-10-17 标题:Synthesis of typhoid fever vaccine from a plant or fruit polysaccharide 发明人:SZU SHOUSUN CHEN; BYSTRICKY SLAVOMIR 权利人:US ARMY 摘要:The present invention is a modified plant, fruit or synthetic oligo- or polysaccharide which has been structurally altered so as to render the modified saccharide antigenically similar to the Vi of Salmonella typhi. The modified saccharide may be conjugated to a carrier to form a conjugate that is immunogenic against S. typhi. Antibodies produced in response to the immunogenic conjugate are protective against typhoid fever. Methods are provided for making the modified saccharide and the immunogenic conjugate.
专利号:US-3627761-A 优先权日:1969-01-17 标 题 :Process for the preparation of cephalosporin 发明人:NEIDLEMAN SAUL LEWIS; LAST JEROLD ALAN; PAN SAMUEL CHENG; DOLFINI JOSEPH EDWARD 权利人:SQUIBB & SONS INC 摘要:A process comprising the treatment of a compound selected from the group consisting of WHERE R represents alkyl having up to seven carbon atoms, phenyl, X-substituted phenyl, naphthyl, X-substituted naphthyl, pyridyl, pyrryl, furyl, thienyl, pyridyl-lower alkyl, pyrryllower alkyl, furyl-lower alkyl, thienyl-lower alkyl, D R A W I N G WHEREIN R2 represents alkyl having up to seven carbon atoms, phenyl, X-substituted phenyl, naphthyl, cyclohexadienyl (e.g., 1,4-cyclohexadienyl, 1,3-cyclohexadienyl, and 2,4cyclohexadienyl), X-substituted naphthyl, pyridyl, pyrryl, furyl, thienyl, pyridyl-lower alkyl, pyrryl-lower alkyl, furyl-lower alkyl, or thienyl-lower alkyl; R3 represents lower alkyl, monocyclic aryl, or monocyclic aryl-lower alkyl; R4 and R5 each represent hydrogen, lower alkyl, monocyclic aryl, or monocyclic aryl-lower alkyl; n is 1, 2, or 3; and X represents lower alkyl, lower alkoxy, or halo; and R1 represents triphenylmethyl, diphenylmethyl, or benzyl, said treatment comprising heating the above compounds to a temperature of about 25* C. to about 100* C. at a pH of about 6 to 11.5. Products prepared by means of the above reaction possess antibacterial activity against a large number of micro-organisms and are intermediates for the synthesis of related compounds (such as cephalothin, cephalexin, cephaloridine) which possess utility known to the art.
摘要:National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Sodium Sesquicarbonate (533-96-0). Available from, as of February 10, 2012: 摘要:Sander JE et al; Avian Dis. 42 (1): 215-8 (1998) 摘要:O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 2006., p. 1490 摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118 摘要:Rom - Rom WN (ed). _Environmental and Occupational Medicine, _4th Ed. Philadelphia: Lippincott Williams & Wilkins, 2007., p. 538