CAS: 4044-65-9; 1,4-Phenylene Diisothiocyanate

该化合物是有机化合物,其特征是附于一种苯二氮基骨的两个异硫氰酸盐功能组,该化合物一般是黄色至褐色固体,以其活性而著称,特别是在形成硫尿素和其他衍生物时,通过增加核生殖反应来形成硫尿素和其他衍生物方面.它溶于丙酮和氯仿等有机溶剂,但在水中溶解性有限. p-Phenyle disotherocyanate主要用于各种聚合物的合成和有机合成中的试剂,特别是用于制造异硫酸盐衍生物.此外,它可用于材料科学和生物化学学领域,可以用来为蛋白质贴标签和研究生物相互作用.然而,必须谨慎地处理这一化合物,因为它可能构成健康风险,包括皮肤和呼吸刺激,因此被认为是危险的.在与该物质合作时,应当遵循适当的安全议定书.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号75-15-0 二硫化碳 | CAS号100-01-6 对硝基苯胺 | CAS号19972-69-1 methyl N-[4-(me... | CAS号106-50-3 对苯二胺 | CAS号108-24-7 乙酸酐 | CAS号463-71-8 硫光气 | CAS号67-66-3 氯仿 | CAS号35353-29-8 1-N,4-N-bis(1,3... | CAS号1519-70-6 1,4-亚苯基二(硫脲) | CAS号26328-53-0 4-硝基-4'-异硫氰基二苯胺 | CAS号56041-34-0 4-phenyl-3-pyri...

合成工艺路线路线简述

  • 合成目标产物 1,4-Phenylene Diisothiocyanate 主要起始原料 P-Phenylenediamine
  • (文献来源)合成步骤主要原料 P-Phenylenediamine
📜N,N'-(1,4-Phenylene)Bis(Methyldithiocarbamate)置于ammonium Hydroxide,Mercury(II) Oxide体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 4.0H,以83%的收率获得产物对苯二异硫氰酸酯
参考文献:Garin,J.; Melendez,E.; Merchan,F.,Bulletin Des Societes Chimiques Belges,1989,Vol. 98,# 4,P. 289-290
标题:Garin,J.; Melendez,E.; Merchan,F.,Bulletin Des Societes Chimiques Belges,1989,Vol. 98,# 4,P. 289-290

专利信息


专利号:US-5554501-A
优先权日:1992-10-29
标题:Biopolymer synthesis using surface activated biaxially oriented polypropylene
发明人:COASSIN PETER J; MATSON ROBERT S; RAMPAL JANG B
权利人:BECKMAN INSTRUMENTS INC
摘要:Disclosed herein are surface activated, organic polymers useful for biopolymer synthesis. Most preferably, aminated biaxially oriented polypropylene is used for the synthesis of oligonucleotides thereto, and these devices are most preferably utilized for genetic analysis of patient samples.

专利号:EP-0721458-B1
优先权日:1993-09-28
标题:Biopolymer synthesis utilizing surface activated, organic polymers
发明人:COASSIN PETER J; MATSON ROBERT S; RAMPAL JANG B
权利人:BECKMAN COULTER INC
摘要:Disclosed herein are surface activated, organic polymers useful for biopolymer synthesis. Most preferably, aminated polypropylene is used for the synthesis of oligonucleotides thereto, and these devices are most preferably utilized for genetic analysis of patient samples.

专利号:US-5583211-A
优先权日:1992-10-29
标 题 :Surface activated organic polymers useful for location - specific attachment of nucleic acids, peptides, proteins and oligosaccharides
发明人:COASSIN PETER J; MATSON ROBERT; RAMPAL JANG
权利人:BECKMAN INSTRUMENTS INC
摘要:Disclosed herein are surface activated, organic polymers useful for biopolymer synthesis. Most preferably, aminated polypropylene is used for the synthesis of oligonucleotides thereto, and these devices are most preferably utilized for genetic analysis of patient samples.

专利号:US-5629394-A
优先权日:1992-12-17
标 题 :Direct synthesis by living cationic polymerization of nitrogen-containing polymers
发明人:CHERADAME HERVE M; CHEN FRANK J; STANAT JON E R; NGUYEN HUNG A; TABAR BEHROOZ R
权利人:EXXON CHEMICAL PATENTS INC
摘要:A method is provided for the direct synthesis by living cationic polymerization of novel polymeric materials functionalized with desirable nitrogen-containing functional groups such as terminal azido, cyano, carbonylamino, cyanato, thiocyanato or thiocarbonylamino groups. Polymerization and functionalization occur in a substantially simultaneous manner. All necessary reactants for the functionalization are present when polymerization is initiated. The nitrogen-containing functional group is provided as a part of a molecule having a release moiety which is preferably resonance stabilized or a tertiary alkyl type and which acts to aid the nitrogen-containing species in functioning as a leaving group.

专利号:US-2008051323-A1
优先权日:2004-08-21
标 题 :Chloroquine drug compositions and methods for their synthesis
发明人:KOSAK KENNETH M
权利人:KOSAK KENNETH M
摘要:This invention discloses compositions of chloroquine-coupled active agents, including methods for their preparation. The prior art has shown that chloroquines given as free drug in high enough concentration, enhances the release of various agents from cellular endosomes into the cytoplasm. The purpose of these compositions is to provide a controlled amount of chloroquine at the same site where the active agent is delivered, thereby reducing the overall dosage needed. n The compositions comprise a chloroquine substance coupled to an active agent directly or through a variety of pharmaceutical carrier substances. The carrier substances include polysaccharides, synthetic polymers, proteins, micelles and other substances for carrying and releasing the chloroquine compositions in the body for therapeutic effect. The compositions can also include a biocleavable linkage for carrying and releasing active agents for therapeutic or other medical uses. The invention also discloses carrier compositions that are coupled to targeting molecules for targeting the delivery of chloroquine substances and active agents to their site of action.

专利号:US-9923142-B2
优先权日:2016-05-31
标 题:Methods of graphene growth and related structures
发明人:CHEN MIIN-JANG; PAN SAMUEL C; HSIEH CHUNG-YEN
权利人:TAIWAN SEMICONDUCTOR MFG CO LTD; UNIV NAT TAIWAN
摘要:A method and structure for providing uniform, large-area graphene by way of a transfer-free, direct-growth process. In some embodiments, a SAM is used as a carbon source for direct graphene synthesis on a substrate. For example, a SAM is formed on an insulating surface, and a metal layer is formed over the SAM. The metal layer may serve as a catalytic metal, whereby the SAM is converted to graphene following an annealing process. The SAM is deposited using a VPD process (e.g., an ALD process and/or an MLD process). In some embodiments, a CNT having a controlled diameter may be formed on the surface of a nanorod by appropriately tuning the geometry of the nanorod. Additionally, in some embodiments, a curved graphene transistor may be formed over a curved oxide surface, thereby providing a band gap in a channel region of the graphene transistor.

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主要参考文献


1: Lainakis NG, Papalois A, Agrogiannis G, Antonopoulos CN, Michail P, Bastounis E, Patsouris E, Felekouras E. Development of an animal model of fibrous cholangitis in pigs. J Invest Surg. 2014 Apr;27(2):95-101. doi: 10.3109/08941939.2013.839010. Epub 2014 Jan 10. doi: 10.1016/j.bios.2012.07.049. Epub 2012 Aug 3. doi: 10.1002/anie.201105717. Epub 2011 Nov 14. doi: 10.1007/s12010-008-8245-9. Epub 2008 May 20. Epub 2005 Aug 1. Erratum in: Int J Cancer. 2005 Dec 20;117(6):1065. German. Review.

合成参考文献


摘要:US EPA; Estimation Programs Interface (EPI). ver. 3.11. U.S. EPA version for Windows. Washington, DC: U.S. EPA (2003). Available from, as of Feb 25, 2005:
摘要:
摘要:U.S. Environmental Protection Agency. 1998. Extremely Hazardous Substances (EHS) Chemical Profiles and Emergency First Aid Guides. Washington, D.C.: U.S. Government Printing Office.
参考文献:10.1007/s00436-001-0535-x
摘要:Harder A. Chemotherapeutic approaches to nematodes: current knowledge and outlook. Parasitol Res. 2002 Mar;88(3):272–7. doi: 10.1007/s00436-001-0535-x.
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