CAS: 6108-05-0; Lidocaine Hydrochloride Monohydrate

2-(二乙基氨基)乙酰胺,2-氯-1,3-二甲苯置于potassium Carbonate,盐酸,水体系中,用 N,N-二甲基甲酰胺,乙酸乙酯,丙酮 作为反应溶剂,化学反应 2.0H,以92.1%的收率获得产物盐酸利多卡因
参考文献:一种11/5水盐酸利多卡因化合物
标题:一种11/5水盐酸利多卡因化合物
摘要:本发明公开了一种1 1 / 5 水盐酸利多卡因化合物及制法,该化合物用粉末x射线衍射测定法测定,以2θ+/-0.2°衍射角表示在6.7°,13.5°,16.6°,20.2°,27.1°,34.0°处显示出特征衍射峰.本发明制备的1 1 / 5 水盐酸利多卡因化合物具有热稳定性好,纯度高,吸湿性弱的优点,而且工艺简单,收率高,重复性强,适合于工业化生产.

专利信息

专利号:US-9828452-B1
优先权日:2004-11-11
标 题 :Process for the synthesis of poly (vinyl alcohol) and/or poly (vinyl acetate) with spherical morphology and shell-and-nucleus structure and its use in vascular embolization
发明人：COSTA DA SILVA PINTO JOSÉ CARLOS; Niemeyer Limeira Mariana Araújo; SILVA FABRICIO MACHADO; MELO PRIAMO ALBUQUERQUE; DE SOUZA MÃ?RCIO NELE; Lopez Galdêncio Espinosa
权利人:COSTA DA SILVA PINTO JOSÉ CARLOS; Niemeyer Limeira Mariana Araújo; SILVA FABRICIO MACHADO; MELO PRIAMO ALBUQUERQUE; DE SOUZA MÃ?RCIO NELE; Lopez Galdêncio Espinosa; INST ALBERTO LUIZ COIMBRA DE PÓS-GRADUAÇÃO E PESQUISA DE ENGENHARIA—COPPE; FIRST LINE IND E COMMERCIA S/A
摘要:The present invention describes a process for the synthesis of spherical particles of polyvinyl alcohol—PVA and/or polyvinyl acetate—PVAc with shell nucleus structure from total or partial hydrolysis in a caustic aqueous medium with obtaining particulates of PVA/PVAc with controlled spherical morphology, to be used in vascular embolization.

专利号:US-6264962-B1
优先权日:1997-12-19
标 题:Use of cinnamic acid or of at least one of its derivatives in a cosmetic composition
发明人：BRETON LIONEL; GIRERD FLORENCE; RENAULT BEATRICE
权利人:OREAL
摘要:The invention relates to the use of cinnamic acid, or of at least one of its derivatives, in a cosmetic composition as an agent for promoting the synthesis of the skin's total lipids. n The invention also relates to a cosmetic composition comprising an effective amount of cinnamic acid or of at least one of its derivatives.

专利号:US-6660283-B2
优先权日:1997-12-19
标 题 :Use of cinnamic acid, or of at least one of its derivatives in a cosmetic composition
发明人：BRETON LIONEL; GIRERD FLORENCE; RENAULT BEATRICE
权利人:OREAL
摘要:The invention relates to the use of cinnamic acid, or of at least one of its derivatives, in a cosmetic composition as an agent for promoting the synthesis of the skin's total lipids.The invention also relates to a cosmetic composition comprising an effective amount of cinnamic acid or of at least one of its derivatives.

专利号:WO-9925385-A1
优先权日:1997-11-17
标 题:A method of increasing nucleic acid synthesis with ultrasound
发明人：UNGER EVAN C; MCCREERY THOMAS; SADEWASSER DAVID
权利人:IMARX PHARMACEUTICAL CORP
摘要:The present invention is directed to a method of increasing nucleic acid synthesis in a cell comprising administering to the cell a therapeutically effective amount of ultrasound for a therapeutically effective time such that said administration of said ultrasound results in said increased nucleic acid synthesis. The nucleic acid sequence may comprise an endogenous sequence or an exogenous sequence.

专利号:US-8178501-B2
优先权日:2004-12-17
标 题:Antibiotic combinations for providing total solution to the treatment of infections
发明人：CHAUDHARY MANU
权利人:CHAUDHARY MANU; VENUS REMEDIES LTD
摘要:The invention relates to a new pharmaceutical composition, a method of treatment of infection and also a process to prepare the composition. The infectious complications are important causes of morbidity and mortality. Hospital acquired pneumonia (HAP) remains the most severe nosocomial infection in intensive care units. Beta-lactams alone are always considered inadequate when P. aeruginosa and/or methicillin-resistant S. aureus are implicated as pathogens or copathognes. The present invention provides the desired empirical therapy for control of all bacterial infections. The invention provides antibiotic combination products for delivering at least two different antibiotics, through parenteral dosage form comprising protein-synthesis-inhibiting antibiotic which is amikacin or its sulphate salt and non-protein-synthesis-inhibiting antibiotic which is cefepime or its hydrochloride salt. The invention provides a total solution, against multiresistant P. aeruginosa , or Acinetobacter spp. and/or methicillin-resistant S. aureus , and are useful for intramuscular or intravenous administration as antibiotics for hospitalized patients with acute or serious infections. The pharmaceutical compositions described here normally have the least nephrotoxicity and have better efficacy and safety of cefepime plus amikacin combination.

专利号:US-9687428-B2
优先权日:2001-05-01
标题 :Hydrogel compositions for tooth whitening
发明人：SINGH PARMINDER; CLEARY GARY W; MUDUMBA SRI; FELDSTEIN MIKHAIL M; BAYRAMOV DANIR F
权利人:A V TOPCHIEV INST OF PETROCHEMICAL SYNTHESIS RUSSIAN ACAD OF SCIENCES; CORIUM INT INC; A V TOPCHIEV INST OF PETROCHEMICAL SYNTHESIS RUSSIAN ACAD OF SCIENCES
摘要:A composition is provided, wherein the composition comprises a water-swellable, water insoluble polymer, a blend of a hydrophilic polymer and a complementary oligomer capable of hydrogen bonding to the hydrophilic polymer, and a whitening agent, preferably a peroxide. The composition finds utility as a tooth whitening composition and is applied to the teeth in need of whitening, and then removed when the degree of whitening has been achieved. In certain embodiments, the composition is translucent. Methods for preparing and using the compositions are also disclosed.