CAS: 813-19-4; 1,1,1,2,2,2-Hexabutyldistannane

该化合物是一种有机锡化合物,其分子式(C4H996Sn2)通常用作有机合成和催化的前体或试剂,其主要优点包括高热稳定性和交叉反应的回动性,使其在先进材料应用中形成碳-锡联结的价值.该化合物的对称结构和定义明确的声学测量法有助于聚合和锡涂层工艺的一贯性能.此外,六丁基锡烷与轻有机锡衍生物相比具有低波动性,提高了实验室和工业环境中的处理安全性.它在专门合成途径中的效用强调了其在有机金属化学和材料科学研究中的重要性.

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物理性质

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9,10-Dicyanoanthracene benzyltributyltin tri-n-butyl-tin hydride N,N-dimethylaminomethylidene-P-phenylphosphinetributyl(thien-2-yl)stannane 2-butyl-4-methylquinoline 2-cyclohexyl-4-methylquinoline tributylphenylstannane

合成工艺路线路线简述

  • 101537-26-2 + 123347-37-5 = 813-19-4 + 111-87-5 + 156517-50-9 + 929-62-4
    反应条件:1.1 Solvents: Tetrahydrofuran
    标题:Regioselective Addition Of Stannylcyanocuprates To Acetylenic Ethers: A Chemical And Spectroscopic Study
    作者:Cabezas,Jorge A.; Oehlschlager,Allan C.
    参考文献:Synthesis 日期:1994 卷标:(4) 页码:432-42]

    1067-52-3 = 813-19-4 [标题:Reaction Conditions
    标题:Hexabutyldistannane
    作者:Mitchell,Terence N.; Et Al
    参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2012 卷标:1 页码:1-6]

    1067-52-3 = 813-19-4
    反应条件:1.1 Catalysts: (+/-)-Benzoin
    标题:2,2-Dibutyl-1,3,2-Dioxastannolenes
    作者:Davies,Alwyn G.; Et Al
    参考文献:Journal Of The Chemical Society 日期:1983 卷标:(4) 页码:875-82]

    = 813-19-4
    反应条件:1.1 Reagents: Sodium Hydroxide,Sodium Borohydride Solvents: Methanol,Tetrahydrofuran
    标题:Preparation Of Distannanes
    参考文献:Germany]

    = 813-19-4
    反应条件:1.1 Reagents: Samarium Iodide (Smi2) Solvents: Tetrahydrofuran,Hexamethylphosphoramide
    标题:Reductions With Samarium(Ii) Iodide
    作者:Molander,Gary A.
    参考文献:Organic Reactions (Hoboken 日期:1994 卷标:46]

    = 813-19-4
    反应条件:1.1 Reagents: Hexamethylphosphoramide,Samarium Iodide (Smi2) Solvents: Tetrahydrofuran
    标题:Rapid And Mild Deoxygenation Of Organoheteroatom Oxides With The Efficient Electron Transfer System Smi2-Tetrahydrofuran-Hexamethylphosphoric Triamide
    作者:Handa,Yuichi; Et Al
    参考文献:Journal Of The Chemical Society 日期:1989 卷标:(5) 页码:298-9]

    1461-22-9 = 813-19-4
    反应条件:1.1 Reagents: Sodium Solvents: Ammonia
    标题:Some Uses Of Tin Compounds In Organic Synthesis
    作者:Rowley,Michael
    参考文献:1986]

    3757-88-8 = 813-19-4 [标题:Reaction Conditions
    标题:Reaction Of α-Acetylene Organotin Compounds With Metallic Sodium
    作者:Komarov,N. V.; Et Al
    参考文献:Zhurnal Obshchei Khimii 日期:1979 卷标:49(10)]

    603-32-7 + 813-19-4 = 813-19-4
    反应条件:1.1 Solvents: Ethanol,Benzene; 40 H,Reflux
    标题:Reactions Of Hexabutylditin With Triphenyl Phosphine And Arsine
    作者:Bansal,Deepika; Et Al
    参考文献:Journal Of Ultra Chemistry 日期:2009 卷标:5(3) 页码:427-429]

    1461-23-0 = 813-19-4
    反应条件:1.1 Reagents: Potassium,18-Crown-6 Solvents: Tetrahydrofuran
    标题:Generation Of C,Si,And Sn Anions Using [k+/k-] Solutions In Thf
    作者:Hevesi,Laszlo; Et Al
    参考文献:Synlett 日期:1995 卷标:(10) 页码:1047-9]

    59431-29-7 = 813-19-4 [标题:Reaction Conditions
    标题:Synthesis And Rearrangement Reactions Of O-Functionalized Phenyllithium And Phenylsodium Derivatives Of Group Ivb And Vb Elements
    作者:Heinicke,J.; Et Al
    参考文献:Journal Of Organometallic Chemistry 日期:1983 卷标:243(1) 页码:1-8]

    1461-22-9 + 4226-01-1 = 813-19-4 [标题:Reaction Conditions
    标题:Hexabutyldistannane
    作者:Mitchell,Terence N.; Et Al
    参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2012 卷标:1 页码:1-6]

    = 813-19-4
    反应条件:1.1 Catalysts: Tetrakis(Triphenylphosphine)Palladium
    标题:Organotin Compounds. Xxxiii. The First Complexation Between Organotin And Nitro Derivatives: Reactions Of The Tin-Alkyl Bond
    作者:Al-Allaf,Talal A. K.; Et Al
    参考文献:Journal Of Organometallic Chemistry 日期:1989 卷标:373(1) 页码:29-35]

    = 813-19-4 [标题:Reaction Conditions
    标题:Hexabutyldistannane
    作者:Mitchell,Terence N.; Et Al
    参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2012 卷标:1 页码:1-6]

    = 813-19-4
    反应条件:1.1 6 H,200 °C
    标题:A Convenient Route To Distannanes,Oligostannanes,And Polystannanes
    作者:Khan,Aman; Et Al
    参考文献:Canadian Journal Of Chemistry 日期:2010 卷标:88(10) 页码:1046-1052]

    = 813-19-4
    反应条件:1.1 4 H,200 °C
    标题:Synthesis Of Hexabutylditin From Tributyltin Hydride And Bis(Tributyltin)Oxide
    作者:Darwish,Alla; Et Al
    参考文献:Synthetic Communications 日期:2004 卷标:34(10) 页码:1885-1890]

    1066-87-1 = 813-19-4 [标题:Reaction Conditions
    标题:Hexabutyldistannane
    作者:Mitchell,Terence N.; Et Al
    参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2012 卷标:1 页码:1-6]

    1461-22-9 = 813-19-4
    反应条件:1.1 Reagents: 1,2-Dibromoethane,Magnesium Solvents: Tetrahydrofuran; 0.5 H,Rt
    标题:Novel Access To Organostannane Compounds Under Ultrasound Irradiation
    作者:Zhao,Zhi-Quan; Et Al
    参考文献:Chinese Journal Of Chemistry 日期:2004 卷标:22(11) 页码:1382-1383]

    1461-22-9 = 813-19-4
    反应条件:1.1 Reagents: Ammonia
    标题:Preparation Of Allylstannanes And Distannanes Using Zinc In Liquid Ammonia
    作者:Makosza,Mieczyslaw; Et Al
    参考文献:Synthetic Communications 日期:1998 卷标:28(14) 页码:2697-2702]

    92074-24-3 = 813-19-4
    反应条件:1.1 Catalysts: Cuprous Cyanide Solvents: Tetrahydrofuran
    标题:Scope And Mechanism Of Stannylalumination Of 1-Alkynes
    作者:Sharma,Sunaina; Et Al
    参考文献:Journal Of Organic Chemistry 日期:1989 卷标:54(21) 页码:5064-73]

    92074-24-3 = 813-19-4
    反应条件:1.1 Catalysts: Cuprous Cyanide Solvents: Tetrahydrofuran
    标题:Scope And Mechanism Of Stannylalumination Of 1-Alkynes
    作者:Sharma,Sunaina; Et Al
    参考文献:Journal Of Organic Chemistry 日期:1989 卷标:54(21) 页码:5064-73]

    35864-20-1 = 813-19-4
    反应条件:1.1 Reagents: Sodium Solvents: Hexane
    标题:Reaction Of α-(Trialkylstannyl)Acetylenes With Metallic Sodium
    作者:Komarov,N. V.; Et Al
    参考文献:Izvestiya Akademii Nauk 日期:1994 卷标:(6) 页码:1109-10]

    35864-20-1 = 813-19-4 [标题:Reaction Conditions
    标题:Reaction Of α-Acetylene Organotin Compounds With Metallic Sodium
    作者:Komarov,N. V.; Et Al
    参考文献:Zhurnal Obshchei Khimii 日期:1979 卷标:49(10)]

    813-19-4 = 813-19-4
    反应条件:1.1 Solvents: Dichloromethane; 35 H,Reflux
    标题:Reactions Of Hexabutylditin With Triphenyl Phosphine And Arsine
    作者:Bansal,Deepika; Et Al
    参考文献:Journal Of Ultra Chemistry 日期:2009 卷标:5(3) 页码:427-429]

    7342-47-4 = 813-19-4
    反应条件:1.1 Reagents: Zinc,Ammonium Chloride Solvents: Tetrahydrofuran,Water
    标题:Wurtz-Type Reductive Coupling Reaction Of Primary Alkyl Iodides And Haloorganotins In Cosolvent/h2O(Nh4Cl)/zn Media As A Route To Mixed Alkylstannanes And Hexaalkyldistannanes
    作者:Marton,D.; Et Al
    参考文献:Journal Of Organometallic Chemistry 日期:2000 卷标:612(1-2) 页码:78-84]

    79411-60-2 = 813-19-4
    反应条件:1.1 Reagents: Water Solvents: Water
    标题:Some Aspects On The Reactivity Of α-Chloro-α-Ethoxymethyltributyltin: Reductive Etherification Of Aromatic Aldehydes And Demonstration Of Formyltributyltin During The Hydrolysis
    作者:Quintard,Jean Paul; Et Al
    参考文献:Journal Of Organometallic Chemistry 日期:1983 卷标:251(2) 页码:175-87]

    1067-24-9 = 813-19-4 [标题:Reaction Conditions
    标题:Product Subclass 1: Tin Hydrides
    作者:Clark,A. J.
    参考文献:Science Of Synthesis 日期:2003 卷标:5 页码:205-271]

    64909-10-0 = 813-19-4
    反应条件:1.1 Catalysts: Acetylene
    标题:Reaction Of Trialkyl Stannanides Of Alkali Metals With Acetylene Compounds
    作者:Zavgorodnii,V. S.; Et Al
    参考文献:Zhurnal Obshchei Khimii 日期:1981 卷标:51(9) 页码:2048-57
📜三丁基氧化锡 反应生成 六正丁基二锡
参考文献:有机锡氧化物,醇盐和酰氧基与有机硅氢化物的反应.有机锡氢化物的新制备方法
标题:有机锡氧化物,醇盐和酰氧基与有机硅氢化物的反应.有机锡氢化物的新制备方法
摘要:通过改变反应物的摩尔比,研究了有机锡氧化物,醇盐和酰氧化物与有机硅氢化物的反应.并且发现sn 3 O容易被si 3 H裂解而得到sn 3H.以非常好的产率获得了几种有机锡氢化物,例如氢化三丁基锡,氢化三丙基锡和二丁基二氢化锡.对于氢化三苯基锡和二甲基二甲基锡,必须使用自由基抑制剂或碘作为促进剂,即使这样产率也很差.还获得了siosn类型的新化合物,例如(三丁基甲硅烷氧基)三丁基锡,(三苯基甲硅烷氧基)三丁基锡和(三苯基甲硅烷氧基)三丙基锡.
DOI:10.1016/s0022-328X(00)81719-2

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专利信息


专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:US-2024409557-A1
优先权日:2023-05-09
标 题 :5,6-fused and 6,6-fused bicyclic alcohols and ethers and compositions for use as 15-prostaglandin dehydrogenase modulators
发明人：GREENMAN KEVIN LLOYD; PICKRELL ALEXANDER J; LI KEXUE; AMEGADZIE ALBERT K; WANG HUI-LING; WEIRES NICHOLAS ANTHONY; ALLEN JOHN G; BOURBEAU MATTHEW P
权利人:AMGEN INC
摘要:The present disclosure provides novel 15-hydroxy-prostaglandin dehydrogenase inhibitors, pharmaceutical compositions comprising such compounds, and methods of using such compounds and compositions in treating 15-hydroxy-prostaglandin dehydrogenase-mediated disease. Also provided are methods of making such compounds and intermediates thereof. The compounds have a general Formula (A).Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (A).

专利号:US-2025026766-A1
优先权日:2022-01-12
标题 :Thiazolopyridyl Amide Derivatives as DNA Polymerase Theta Inhibitors
发明人：LI JING; XU WENQING; WANG ZHIWEI
权利人:BEIGENE LTD
摘要:The present invention relates to compounds containing thiazolopyridyl amide structure, the process for their synthesis, as well as the use of such compounds for inhibiting DNA Polymerase Theta (Pol Theta), and in the treatment of various diseases including cancers.

专利号:US-9192612-B2
优先权日:2013-02-13
标题:Heteroaryl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
发明人：BRODNEY MICHAEL AARON; BUTLER CHRISTOPHER RYAN; BECK ELIZABETH MARY; DAVOREN JENNIFER ELIZABETH; LACHAPELLE ERIK ALPHIE; O'NEILL BRIAN THOMAS
权利人:PFIZER
摘要:The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, n nand the variables R 1 and R 2 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-2025188097-A1
优先权日:2023-12-11
标 题 :Organoboron compound, its preparation and use
发明人：LU ZHENPIN; LI HAOKUN
权利人:UNIV CITY HONG KONG
摘要:An organoboron compound for reductive synthesis includes a structure of Formula (I). A method for preparing the organoboron compound includes providing a first precursor having a structure of Formula (IV), with R1 and R2 each being the mono-, di or tri substitution, and converting the first precursor into the organoboron compound.

专利号:US-9233981-B1
优先权日:2013-02-15
标题:Substituted phenyl hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
发明人：BRODNEY MICHAEL AARON; O'NEILL BRIAN THOMAS; BUTLER CHRISTOPHER RYAN; BECK ELIZABETH MARY
权利人:PFIZER
摘要:The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, n nwherein the variables R 1 and R 2 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

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摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
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