专利号:US-7355036-B2 优先权日:2001-07-03 标 题 :Two-stage protective groups for the synthesis of biopolymers 发明人:GUEIMIL RAMON; SCHEFFLER MATTHIAS; STAEHLER PEER F; BEIJER BARBRO 权利人:FEBIT AG 摘要:The invention relates to a method for the synthesis of a nucleic acid by gradual breakdown from protected synthesis building blocks carrying two-stage protective groups. The two-stage protective groups are split by means of a first exposure step and a subsequent chemical treatment step
专利号:US-2007088174-A1 优先权日:2005-10-19 标 题 :Synthesis of phenoxyacetic acid derivatives 发明人:WINTER ERIC; REICHEL CARSTEN; GUTHEIL DIETER 权利人:BOEHRINGER INGELHEIM INT 摘要:The present invention relates to an improved process for the preparation of substituted 2-(4-carbonylmethoxy-optionally 2,5-disubstituted-phenyl)-acetaldehydes, in particular 2-(4-alkoxycarbonylmethoxy-optionally 2,5-disubstituted-phenyl)-acetaldehydes and their use in the synthesis of optionally substituted 2-[4-[2-[[-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]-amino]ethyl]-optionally 2,5-disubstituted-phenoxy]acetic acid derivatives or the salts thereof, which may be used as pharmaceutically active substances.
专利号:US-2009247781-A1 优先权日:2004-10-26 标 题:Synthesis of phenoxyacetic acid derivatives 发明人:WINTER ERIC; REICHEL CARSTEN; GUTHEIL DIETER 权利人:KISSEI PHARMACEUTICAL 摘要:The present invention relates to an improved process for the preparation of substituted 2-(4-carbonylmethoxy-optionally 2,5-disubstituted-phenyl-acetaldehydes, in particular 2-(4-alkoxycarbonylmethoxy-optionally 2,5-disubstituted-phenyl)-acetaldehydes and their use in the synthesis of optionally substituted 2-[4-[2-[[-2-hydroxy-2-(4-hydroxyphenyl)- 1 -methylethyl]-amino]ethyl]-optionally 2,5-disubstituted-phenoxy]acetic acid derivatives or the salts thereof, which may be used as pharmaceutically active substances.
专利号:EP-1730108-B1 优先权日:2004-03-18 标 题:Stereoselective synthesis of vitamin d analogues 发明人:SABROE THOMAS PETER; CALVERLEY MARTIN JOHN 权利人:LEO PHARMA AS 摘要:The present invention relates to intermediates useful for the synthesis of calcipotriol or calcipotriol monohydrate, to methods of producing said intermediates, and to methods of stereoselectively reducing said intermediates.
专利号:EP-1735276-B1 优先权日:2004-04-02 标题:Novel method for the preparation of intermediates useful for the synthesis of vitamin d analogues 发明人:HANSEN ERIK TORNGAARD; SABROE THOMAS PETER; CALVERLEY MARTIN JOHN; PEDERSEN HENRIK; DEUSSEN HEINZ-JOSEF WILHELM 权利人:LEO PHARMA AS 摘要:The present invention relates to novel methods for the preparation of intermediates which are useful in the synthesis of cacipotriol. The present invention relates further to the use of intermediates produced with said methods for making calcipotriol or calcipotriol monohydrate.
专利号:US-8759555-B2 优先权日:2004-03-18 标 题:Stereoselective synthesis of vitamin D analogues 发明人:SABROE THOMAS PETER; CALVERLEY MARTIN JOHN 权利人:SABROE THOMAS PETER; CALVERLEY MARTIN JOHN; LEO PHARMA AS 摘要:The present invention relates to intermediates useful for the synthesis of calcipotriol or calcipotriol monohydrate, to methods of producing said intermediates, and to methods of stereoselectively reducing said intermediates.