专利号:US-5612217-A 优先权日:1994-10-25 标 题 :Streptomyces sp. MA 7074 (ATCC 55605) used for microbial synthesis of HIV protease inhibitors 发明人:SHAFIEE ALI; CHEN SHIEH-SHUNG T; ARISON BYRON H; MILLER RANDALL R; GARRITY GEORGE M; HEIMBUCH BRIAN 权利人:MERCK & CO INC 摘要:Biotransformation products of a fermentation with culture MA7074 are potent HIV protease inhibitors. These products are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
专利号:US-8535689-B2 优先权日:2007-10-01 标题 :Identification of bacterial autoinducer and use in treating bacterial pathogenicity 发明人:BASSLER BONNIE; SEMMELHACK MARTIN; HIGGINS DOUGLAS A; BOLITHO MEGAN EILEEN; KRAML KRISTINA M; NG WAI-LEUNG 权利人:BASSLER BONNIE; SEMMELHACK MARTIN; HIGGINS DOUGLAS A; BOLITHO MEGAN EILEEN; KRAML KRISTINA M; NG WAI-LEUNG; UNIV PRINCETON 摘要:A bacterial autoinducer, CAI-1, was purified and its structure identified. Methods for synthesis of the autoinducer and its analogues were elucidated. Methods of using the autoinducer or its analogues for treating bacterial pathogenicity and bio film formation are described. Methods for prevention and treatment of cholera are described. Synthetic (S)-3-hydroxytridecan-4-one functions as well as natural CAI-1 in repressing production of the virulence factor toxin co-regulated pilus (TCP). Strategies are described to manipulate bacterial quorum sensing in the clinical arena.
专利号:US-2017246690-A1 优先权日:2014-06-20 标 题:Stabilizing agent-free metal nanoparticle synthesis and uses of metal nanoparticles synthesized therefrom 发明人:MURPHY RYAN J; DREYFUS REMI; HOUGH LAWRENCE ALAN; MALASSIS LUDIVINE; MURRAY CHRISTOPHER; DONNIO BERTRAND 权利人:RHODIA OPERATIONS; CENTRE NAT RECH SCIENT; UNIV PENNSYLVANIA 摘要:Described herein are methods of synthesizing metal nanoparticles and the metal nanoparticles synthesized therefrom. Further described in the present disclosure are methods of modifying the surfaces of metal nanoparticles and the metal nanoparticles modified thereby. Also described herein are uses of such metal nanoparticles.
专利号:US-2025228841-A1 优先权日:2024-01-12 标题 :Compositions affecting pigment production and methods for treatment of bacterial diseases 发明人:Lee Wai Yip Thomas; LO KAI YIP GEORGE 权利人:APTORUM THERAPEUTICS LTD 摘要:Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (II):The present methods include administering to a subject an effective amount of one or more compounds of Formula (II). In one embodiment, said microbial infections are bacterial infections. More specifically, the bacterial infections are staphylococcal infections. Compositions are provided that include compounds of formula II in combination with one or more antibiotics or one or more staphyloxanthin-synthesis-inhibiting compounds.
专利号:US-6214875-B1 优先权日:1998-04-14 标题:Anticancer effects of specific branched-chain fatty acids and related production process 发明人:YANG ZHENHUA 摘要:A group of specific branched-chain fatty acids, with significant anticancer effects on human and animals; methods of making using either chemical synthesis or biosynthesis methods; and methods of treating cancer.
专利号:CN-106852132-A 优先权日:2014-06-20 标题:Stabilizer-free synthesis of metal nanoparticles and use of metal nanoparticles synthesized therefrom
1: Kitahara T, Aono S, Mori K. Synthesis of both the enantiomers of aseanostatin P5 (sarcinic acid), an inhibitor of myeloperoxidase release, and four diastereomers of aggreceride A, a platelet aggregation inhibitor. Biosci Biotechnol Biochem. 1995 Jan;59(1):78-82. doi: 10.1271/bbb.59.78. 44(5):533-40. doi: 10.7164/antibiotics.44.533. 44(5):524-32. doi: 10.7164/antibiotics.44.524. 26(2):273-282.e7. doi: 10.1016/j.chom.2019.07.002. Epub 2019 Aug 1. 5: Kameoka H, Tsutsui I, Saito K, Kikuchi Y, Handa Y, Ezawa T, Hayashi H, Kawaguchi M, Akiyama K. Stimulation of asymbiotic sporulation in arbuscular mycorrhizal fungi by fatty acids. Nat Microbiol. 2019 Oct;4(10):1654-1660. doi: 10.1038/s41564-019-0485-7. Epub 2019 Jun 24. 15(5):e2002214. doi: 10.1371/journal.pbio.2002214. 7: Inoue T, Shingaki R, Fukui K. Inhibition of swarming motility of Pseudomonas aeruginosa by branched-chain fatty acids. FEMS Microbiol Lett. 2008 Apr;281(1):81-6. doi: 10.1111/j.1574-6968.2008.01089.x. 79(12):4696-701. doi: 10.1021/ac0702894. Epub 2007 May 18. 73(4):594-6. doi: 10.1042/bj0730594.
合成参考文献
摘要:Final Report 04/2019 Available from CIR 参考文献:10.1099/ijs.0.02733-0 摘要:Donachie SP, Bowman JP, Alam M. Psychroflexus tropicus sp. nov., an obligately halophilic Cytophaga-Flavobacterium-Bacteroides group bacterium from an Hawaiian hypersaline lake. Int J Syst Evol Microbiol. 2004 May;54(Pt 3):935–40. doi: 10.1099/ijs.0.02733-0. 参考文献:10.1007/s11033-020-05709-8 摘要:Patra S, Praharaj PP, Panigrahi DP, Panda B, Bhol CS, Mahapatra KK, Mishra SR, Behera BP, Jena M, Sethi G, Patil S, Patra SK, Bhutia SK. Bioactive compounds from marine invertebrates as potent anticancer drugs: the possible pharmacophores modulating cell death pathways. Molecular Biology Reports. 2020 Aug 14;47(9):7209–28. doi: 10.1007/s11033-020-05709-8. 参考文献:10.1186/1471-2091-5-1 摘要:Toman R, Garidel P, Andrä J, Slaba K, Hussein A, Koch MH, Brandenburg K. Physicochemical characterization of the endotoxins from Coxiella burnetii strain Priscilla in relation to their bioactivities. BMC Molecular and Cell Biology. 2004 Jan 12;5(1):1. doi: 10.1186/1471-2091-5-1.