CAS: 5502-94-3; 12-Methyltetradecanoic Acid

该化合物是含有分子式C15H30O2的分链脂肪酸,其特征为第12个碳位置的甲基组,该化合物影响其物理和化学特性,如熔点和溶性.该化合物在生化研究中通常使用,特别是在涉及脂新陈代谢,薄膜结构和细菌脂肪分析的研究中使用.其分支结构使它成为色谱应用和质谱测量的宝贵参考标准.该化合物的稳定性和明确界定的结构确保实验环境中的可复制性,使其成为分析和合成化学应用的可靠选择.

结构式图片

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5129-66-8 5918-29-6 1070-68-4

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ECHA物质C&L通报

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CAS号112-38-9 十一烯酸 | CAS号592-34-7 氯甲酸正丁酯 | CAS号111045-01-3 10-Keto-12-meth... | CAS号41059-02-3 9-溴壬酸 | CAS号70794-53-5 [1-(ethoxycarbo... | CAS号62691-05-8 (S)-12-Methylte... | CAS号14065-32-8 10-氯-10-氧代癸酸甲酯 | CAS号818-88-2 癸二酸单甲酯 | CAS号106-79-6 癸二酸二甲酯 | CAS号19207-26-2 aggreceride A

合成工艺路线路线简述

    📜6-[5-(2-Methyl-Butyl)-Thiophen-2-Yl]-6-Oxo-Hexanoic Acid置于hydroxide,肼体系中,化学反应 2.0H,反应生成 12-甲基十四烷酸
    参考文献:58.噻吩用作扩链剂.第二部分 合成支链链烷酸
    标题:58.噻吩用作扩链剂.第二部分 合成支链链烷酸
    摘要:
    DOI:10.1039/jr9620000350

    海关参考信息

    专利信息


    专利号:US-5612217-A
    优先权日:1994-10-25
    标 题 :Streptomyces sp. MA 7074 (ATCC 55605) used for microbial synthesis of HIV protease inhibitors
    发明人:SHAFIEE ALI; CHEN SHIEH-SHUNG T; ARISON BYRON H; MILLER RANDALL R; GARRITY GEORGE M; HEIMBUCH BRIAN
    权利人:MERCK & CO INC
    摘要:Biotransformation products of a fermentation with culture MA7074 are potent HIV protease inhibitors. These products are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

    专利号:US-8535689-B2
    优先权日:2007-10-01
    标题 :Identification of bacterial autoinducer and use in treating bacterial pathogenicity
    发明人:BASSLER BONNIE; SEMMELHACK MARTIN; HIGGINS DOUGLAS A; BOLITHO MEGAN EILEEN; KRAML KRISTINA M; NG WAI-LEUNG
    权利人:BASSLER BONNIE; SEMMELHACK MARTIN; HIGGINS DOUGLAS A; BOLITHO MEGAN EILEEN; KRAML KRISTINA M; NG WAI-LEUNG; UNIV PRINCETON
    摘要:A bacterial autoinducer, CAI-1, was purified and its structure identified. Methods for synthesis of the autoinducer and its analogues were elucidated. Methods of using the autoinducer or its analogues for treating bacterial pathogenicity and bio film formation are described. Methods for prevention and treatment of cholera are described. Synthetic (S)-3-hydroxytridecan-4-one functions as well as natural CAI-1 in repressing production of the virulence factor toxin co-regulated pilus (TCP). Strategies are described to manipulate bacterial quorum sensing in the clinical arena.

    专利号:US-2017246690-A1
    优先权日:2014-06-20
    标 题:Stabilizing agent-free metal nanoparticle synthesis and uses of metal nanoparticles synthesized therefrom
    发明人:MURPHY RYAN J; DREYFUS REMI; HOUGH LAWRENCE ALAN; MALASSIS LUDIVINE; MURRAY CHRISTOPHER; DONNIO BERTRAND
    权利人:RHODIA OPERATIONS; CENTRE NAT RECH SCIENT; UNIV PENNSYLVANIA
    摘要:Described herein are methods of synthesizing metal nanoparticles and the metal nanoparticles synthesized therefrom. Further described in the present disclosure are methods of modifying the surfaces of metal nanoparticles and the metal nanoparticles modified thereby. Also described herein are uses of such metal nanoparticles.

    专利号:US-2025228841-A1
    优先权日:2024-01-12
    标题 :Compositions affecting pigment production and methods for treatment of bacterial diseases
    发明人:Lee Wai Yip Thomas; LO KAI YIP GEORGE
    权利人:APTORUM THERAPEUTICS LTD
    摘要:Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (II):The present methods include administering to a subject an effective amount of one or more compounds of Formula (II). In one embodiment, said microbial infections are bacterial infections. More specifically, the bacterial infections are staphylococcal infections. Compositions are provided that include compounds of formula II in combination with one or more antibiotics or one or more staphyloxanthin-synthesis-inhibiting compounds.

    专利号:US-6214875-B1
    优先权日:1998-04-14
    标题:Anticancer effects of specific branched-chain fatty acids and related production process
    发明人:YANG ZHENHUA
    摘要:A group of specific branched-chain fatty acids, with significant anticancer effects on human and animals; methods of making using either chemical synthesis or biosynthesis methods; and methods of treating cancer.

    专利号:CN-106852132-A
    优先权日:2014-06-20
    标题:Stabilizer-free synthesis of metal nanoparticles and use of metal nanoparticles synthesized therefrom

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Kitahara T, Aono S, Mori K. Synthesis of both the enantiomers of aseanostatin P5 (sarcinic acid), an inhibitor of myeloperoxidase release, and four diastereomers of aggreceride A, a platelet aggregation inhibitor. Biosci Biotechnol Biochem. 1995 Jan;59(1):78-82. doi: 10.1271/bbb.59.78. 44(5):533-40. doi: 10.7164/antibiotics.44.533. 44(5):524-32. doi: 10.7164/antibiotics.44.524. 26(2):273-282.e7. doi: 10.1016/j.chom.2019.07.002. Epub 2019 Aug 1.
    5: Kameoka H, Tsutsui I, Saito K, Kikuchi Y, Handa Y, Ezawa T, Hayashi H, Kawaguchi M, Akiyama K. Stimulation of asymbiotic sporulation in arbuscular mycorrhizal fungi by fatty acids. Nat Microbiol. 2019 Oct;4(10):1654-1660. doi: 10.1038/s41564-019-0485-7. Epub 2019 Jun 24. 15(5):e2002214. doi: 10.1371/journal.pbio.2002214.
    7: Inoue T, Shingaki R, Fukui K. Inhibition of swarming motility of Pseudomonas aeruginosa by branched-chain fatty acids. FEMS Microbiol Lett. 2008 Apr;281(1):81-6. doi: 10.1111/j.1574-6968.2008.01089.x. 79(12):4696-701. doi: 10.1021/ac0702894. Epub 2007 May 18. 73(4):594-6. doi: 10.1042/bj0730594.

    合成参考文献


    摘要:Final Report 04/2019 Available from CIR
    参考文献:10.1099/ijs.0.02733-0
    摘要:Donachie SP, Bowman JP, Alam M. Psychroflexus tropicus sp. nov., an obligately halophilic Cytophaga-Flavobacterium-Bacteroides group bacterium from an Hawaiian hypersaline lake. Int J Syst Evol Microbiol. 2004 May;54(Pt 3):935–40. doi: 10.1099/ijs.0.02733-0.
    参考文献:10.1007/s11033-020-05709-8
    摘要:Patra S, Praharaj PP, Panigrahi DP, Panda B, Bhol CS, Mahapatra KK, Mishra SR, Behera BP, Jena M, Sethi G, Patil S, Patra SK, Bhutia SK. Bioactive compounds from marine invertebrates as potent anticancer drugs: the possible pharmacophores modulating cell death pathways. Molecular Biology Reports. 2020 Aug 14;47(9):7209–28. doi: 10.1007/s11033-020-05709-8.
    参考文献:10.1186/1471-2091-5-1
    摘要:Toman R, Garidel P, Andrä J, Slaba K, Hussein A, Koch MH, Brandenburg K. Physicochemical characterization of the endotoxins from Coxiella burnetii strain Priscilla in relation to their bioactivities. BMC Molecular and Cell Biology. 2004 Jan 12;5(1):1. doi: 10.1186/1471-2091-5-1.
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