CAS: 594-30-9; Triphenylbismuthdichloride
该化合物是有机体化合物,其独特的结构特征包括三联苯组和两个氯原子,该化合物一般是白色至光黄色固体,以水溶性较低而著称,但可溶于氯仿和苯等有机溶剂中.二氯化三联苯具有有趣的化学特性,包括由于存在可以接受电子对子的双苯基中心而具有作为刘易斯酸的能力.该化合物经常用于有机合成,特别是在涉及形成碳结和各种化学变异的试剂的反应中.此外,该化合物在医药化学和材料科学中的潜在用途引起了注意,尽管由于与二氯化合物有关的毒性,应当遵守安全防范措施.
相似化合物
603-33-8 6729-60-8 2023-48-5MSDS等安全信息
欧盟法规
ECHA物质C&L通报上下游产品
iodine trichloride triphenylbismuthane triphenylbismuth dihydroxide chlorinetriphenylbismuthane 3-methyl-3-phenyl-3H-indole isoflavanone 3,3-diphenylchroman-4-one合成工艺路线路线简述
📜三苯基铋置于磺酰氯体系中,用 二氯甲烷 作为反应溶剂,以86 %的收率获得产物三苯基二氯化铋
参考文献:三苯基二氯化铋促进硫代酰胺脱硫一锅法合成2-芳基化和2-烷基化苯并恶唑和苯并咪唑
标题:三苯基二氯化铋促进硫代酰胺脱硫一锅法合成2-芳基化和2-烷基化苯并恶唑和苯并咪唑
摘要:2-取代苯并唑衍生物是具有生物活性的物质,因此开发新颖且有效的合成方法引起了人们的兴趣.本文描述了合成 2-芳基-和 2-烷基-取代的苯并唑的简单方法. 2-氨基苯酚与硫代酰胺在 60 oc 下,在二氯化三苯基铋的存在下,在 1,2-二氯乙烷中作为促进剂,在温和的反应条件下以中等至优异的收率提供各种 2-芳基-和 2-烷基苯并恶唑.该方法也可用于苯并咪唑和苯并噻唑的合成.本研究首次使用三苯基二氯化铋通过硫代酰胺经脱硫和氯化生产苯甲亚胺酰氯,及其在2-取代苯并唑合成中的应用.
DOI:10.3762/bjoc.18.155
海关参考信息
- 2902200000-苯
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专利信息
专利号:US-2005192265-A1
优先权日:2003-03-20
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
专利号:US-6849650-B2
优先权日:1998-02-27
标 题:Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THORSETT EUGENE D; PORTER WARREN J; NISSEN JEFFREY S; LATIMER LEE H; AUDIA JAMES E; DROSTE JAMES
权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
专利号:US-6906056-B2
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
权利人:LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
专利号:US-7390801-B2
优先权日:1996-12-23
标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THORSETT EUGENE D; PLEISS MICHAEL A; LATIMER LEE H; JOHN VARGHESE; FREEDMAN STEPHEN; BRITTON THOMAS C; AUDIA JAMES A; REEL JON K; DRESSMAN BRUCE A; DROSTE JAMES J; HENRY STEVEN S; STUCKY RUSSELL D; PORTER WARREN J
权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
专利号:US-2002045747-A1
优先权日:1996-12-23
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
专利号:US-2002052359-A1
优先权日:1996-12-23
标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting B-amyloid peptide release and/or its synthesis by use of such compounds
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
合成方法参考DOI号:10.1002/chem.201604914
📝 需求与反馈
尽可能描述清楚需求与问题信息
