临床前CDMO研发筛选相关化合物

CDMO是Contract Development and Manufacturing Organization的缩写，即合同定制研发生产组织。它是一种为制药企业及生物技术公司提供医药（特别是创新药）工艺研发及制备、工艺优化、放大生产、注册和验证批生产以及商业化生产等定制服务的机构. 在传统代工基础上增加了研发和工艺优化能力，是高技术壁垒的工艺研发能力与规模生产能力的深度结合. 1, 工艺开发与优化：创新性合成路线设计、工艺参数优化. 2, 中试放大：实验室工艺向规模化生产的转化 3, 注册批生产：支持客户新药申报的验证批生产. 4, 商业化生产：药品上市后的大规模生产供应. 全球医药CDMO行业保持较高景气度。根据弗若斯特沙利文预测：2026年全球CDMO市场规模：预计达1,189亿美元 2033年全球CDMO市场规模：预计达3,385亿美元. CDMO作为医药产业链专业化分工的产物，已经从单纯的CMO代工模式升级为"研发+生产"一体化的高附加值服务。当前，在多肽、ADC、CGT等新型药物赛道的驱动下，全球及中国CDMO市场保持高速增长。中国CDMO企业凭借完整的供应链体系、工程师红利和一体化服务能力，全球市占率有望持续提升，行业正从"成本优势"竞争迈向"体系优势"竞争的新阶段。
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临床前CDMO研发化合物筛选

CAS: 59-02-9

Vitamin E

中文名称:维生素E油
CAS号:59-02-9
分子式: C29H50O2 分子量: 430.71
产品形式: free base
研发状态: Not yet recruiting
研发用途: Dietary Exposure; Diabetes Mellitus Type 2; Cardiovascular Diseases; Bone Loss; Sustainability; Exposure; Obesity; Vitamin Deficiency; Mineral Deficiency
研究机构: German Federal Institute for Risk Assessment; Max Rubner-Institut; University of Bonn; Research Institute for Plant-Based Nutrition; University of Jena; University of Regensburg; Heidelberg University; University of Vienna
研发日期: April 1 2024
研发阶段: --
Vitamin E (D-alpha-Tocopherol) is a fat-soluble vitamin with potent antioxidant properties. It is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription.

CAS: 58-96-8

Uridine

中文名称:尿苷
CAS号:58-96-8
分子式: C9H12N2O6 分子量: 244.20
产品形式: free base
研发状态: Recruiting
研发用途: Ischemic Stroke
研究机构: Barts & The London NHS Trust; Queen Mary University of London; Nutricia Research
研发日期: July 11 2023
研发阶段: Not Applicable
Uridine (NSC 20256,β-Uridine, Uridin) is a nucleoside, contains a uracil attached to a ribose ring via a β-N1-glycosidic bond.

CAS: 58-85-5

Biotin (Vitamin B7)

中文名称:D-生物素
CAS号:58-85-5
分子式: C10H16N2O3S 分子量: 244.31
产品形式: free base
研发状态: Not yet recruiting
研发用途: Breast Cancer
研究机构: Istituto Scientifico Romagnolo per lo Studio e la cura dei Tumori
研发日期: Jun-24
研发阶段: Phase 1
Biotin(Vitamin B7) is a water-soluble B-vitamin and is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids.

CAS: 58749-22-7

Licochalcone A

中文名称:甘草查尔酮A
CAS号:58749-22-7
分子式: C21H22O4 分子量: 338.40
产品形式: free base
研发状态: Completed
研发用途: Acne Vulgaris; Acne
研究机构: Mahidol University; Beiersdorf
研发日期: June 1 2019
研发阶段: Not Applicable
Licochalcone A is an estrogenic flavanoid extracted from licorice root, showing antimalarial, anticancer, antibacterial and antiviral activities. Phase 3.

CAS: 58-64-0

ADP

中文名称:腺苷-5'-二磷酸
CAS号:58-64-0
分子式: C10H15N5O10P2 分子量: 427.20
产品形式: free base
研发状态: Not yet recruiting
研发用途: Alzheimer''s Disease Psychosis
研究机构: ACADIA Pharmaceuticals Inc.
研发日期: Apr-24
研发阶段: Phase 3
ADP (Adenosine diphosphate, adenosine pyrophosphate, Adenosine 5'-diphosphate) is an important organic compound in metabolism and is essential to the flow of energy in living cells.

CAS: 58-63-9

Inosine

中文名称:肌苷
CAS号:58-63-9
分子式: C10H12N4O5 分子量: 268.23
产品形式: free base
研发状态: Completed
研发用途: Healthy Volunteers
研究机构: University Hospital Basel Switzerland
研发日期: February 28 2022
研发阶段: Not Applicable
Inosine (NSC 20262, INO 495) is a nucleoside that is formed when hypoxanthine is attached to a ribose ring via a β-N9-glycosidic bond.