87081-58-1 + 81201-97-0 + 110187-42-3 = 58-64-0 + 57-00-1 + 110-15-6 + 53-57-6 反应条件:1.1R:Cleland'S Reagent,R:Mgcl2,R:R:R:R:R:R:H2O,R:Koh,R:Nh4Cl,C:56-65-5,C:Coenzyme Ii,C:9001-51-8,C:9001-40-5,C:9073-95-4,C:9023-83-0,C:9015-83-2,C:9026-23-7,C:9012-49-1,C:9024-93-5,C:9029-03-2,C:9030-25-5,C:9024-62-8,C:37278-21-0,C:9013-02-9,C:9029-12-3,C:9001-15-4,C:1927-31-7,S:H2O 标题:Enzymatic De Novo Pyrimidine Nucleotide Synthesis 作者:By Schultheisz,Heather L. Et Al 参考文献:Journal Of The American Chemical Society 日期:2011 卷标:133(2) 页码:297-304]
= 58-64-0 + 1062-98-2 + 56983-23-4 反应条件:1.1R:4-Ethylmorpholine,R:Mgcl2,S:Thf,S:H2O 标题:Magnesium(Ii) Ion-Mediated Conversion Of Mono- And Oligonucleotides To 5'-Polyphosphates In Aqueous Solution 作者:By Sawai,Hiroaki Et Al 参考文献:Tetrahedron Letters 日期:1993 卷标:34(30) 页码:4801-4]
50-69-1 + 73-24-5 = 58-64-0 反应条件:1.1R:Po43-,R:H2O,2 H,150°C 标题:Confinement And Time Immemorial: Prebiotic Synthesis Of Nucleotides On A Porous Mineral Nanoreactor 作者:By Rodrigues,Francisco Et Al 参考文献:Journal Of Physical Chemistry Letters 日期:2019 卷标:10(15) 页码:4192-4196]
50-99-7 = 58-64-0 反应条件:1.1R:Na Orthophosphate,R:Mgcl2,R:Nacl,C:9001-51-8,S:H2O,2-3 Min,293K,Ph 7.6 标题:Integrated Ph Measurement During Reaction Monitoring With Dual-Reception 1H-31P Nmr Spectroscopy 作者:By Cox,Neil Et Al 参考文献:Analytical Chemistry (Washington 日期:2019 卷标:91(6) 页码:3959-3963]
= 58-64-0 + 76991-64-5 + 81410-37-9 反应条件:1.1R:Tris Buffer,R:Mgcl2,R:Cleland'S Reagent,C:69106-44-1,S:H2O,15 Min,30°C,Ph 7.5; 5 Min,95°C1.2C:62213-21-2,2 H,37°C; 5 Min,95°C 标题:High Yield Synthesis,Purification And Characterisation Of The Rnase L Activators 5'-Triphosphate 2'-5'-Oligoadenylates 作者:By Morin,B. Et Al 参考文献:Antiviral Research 日期:2010 卷标:87(3) 页码:345-352]
= 58-64-0 反应条件:1.1R:Naod,C:1801427-51-9,S:D2O,37°C,Ph 7.4 标题:Intrinsic Apyrase-Like Activity Of Cerium-Based Metal-Organic Frameworks (Mofs): Dephosphorylation Of Adenosine Tri- And Diphosphate 作者:By Yang,Jian Et Al 参考文献:Angewandte Chemie 日期:2020 卷标:59(51) 页码:22952-22956]
288-32-4 = 58-64-0 反应条件:1.1R:S:H2O,S:Mecn,1 H,40°C2.1R:Na Orthophosphate 标题:One-Pot Synthesis Of Nucleotides In Water Medium 作者:By Depaix,Anais Et Al 参考文献:Phosphorus 日期:2019 卷标:194(4-6) 页码:335-336]
= 58-64-0 + 2211158-60-8 反应条件:1.1R:(Meo)3Po,5 Min,0°C1.2R:Pocl3,0°C; 2 H,0°C1.3R:2Bu3N h4P2O7,S:Dmf,> 1 Min,0°C1.4R:Bu3N,2 H,0°C1.5R:Et4N+ br-,5 Min,0°C2.1R:Mgcl2,R:Kcl,C:9024-82-2,S:Etoh,S:H2O,3 Min,37°C,Ph 7.82.2C:9032-70-6,30 Min,37°C3.1R:Mncl2,R:Nacl,R:Kcl,C:9032-66-0,S:H2O 标题:Emissive Synthetic Cofactors: Enzymatic Interconversions Of Tza Analogues Of Atp,Nad+,Nadh,Nadp+,And Nadph 作者:By Halle,Francois Et Al 参考文献:Angewandte Chemie 日期:2018 卷标:57(4) 页码:1087-1090]
99-50-3 + 63-68-3 = 58-64-0 + 645-08-9 + 121-34-6 反应条件:1.1R:Mgcl2,R:Kcl,C:9026-44-2,C:9013-02-9,C:61-19-8,C:9012-25-3,C:9012-52-6,C:29908-03-0,S:H2O,20 H,37°C,Ph 7.51.2R:HCLo4 标题:Catalytic Alkylation Using A Cyclic S-Adenosylmethionine Regeneration System 作者:By Mordhorst,Silja Et Al 参考文献:Angewandte Chemie 日期:2017 卷标:56(14) 页码:4037-4041]
= 58-64-0 反应条件:1.1R:R:1H-Imidazole,S:H2O,S:Mecn,30 Min,40°C1.2R:Nah2Po4,2 H,40°C 标题:One-Pot Synthesis Of Nucleotides And Conjugates In Aqueous Medium 作者:By Depaix,Anais Et Al 参考文献:European Journal Of Organic Chemistry 日期:2017 卷标:2017(2) 页码:241-245]
= 58-64-0 反应条件:1.1R:Licl,C:1980854-55-4,S:D2O,40 H,Rt 标题:Gallium(Iii)-Containing,Sandwich-Type Heteropolytungstates: Synthesis,Solution Characterization,And Hydrolytic Studies Toward Phosphoester And Phosphoanhydride Bond Cleavage 作者:By Kandasamy,Balamurugan Et Al 参考文献:Inorganic Chemistry 日期:2016 卷标:55(18) 页码:9204-9211
专利号:US-2022297083-A1 优先权日:2019-08-27 标 题 :Continuous Synthesis Of Porous Coordination Polymers In Supercritical Carbon Dioxide 发明人:RASMUSSEN ELIZABETH G; KRAMLICH JOHN C; NOVOSSELOV IGOR V 权利人:UNIV WASHINGTON 摘要:This disclosure relates generally relates to methods and systems useful for continuous synthesis of materials in super-critical carbon dioxide (sCO 2 ). More particularly, this disclosure relates to methods and systems useful for continuous synthesis of coordination polymers, such as metal-organic frameworks (MOFs) and/or covalent organic frameworks (COFs), in sCO 2 .
专利号:US-9376461-B2 优先权日:2011-06-06 标 题:Non-enzymatic synthesis of O-acetyl-ADP-ribose and analogues thereof 发明人:KOPPETSCH KARSTEN; SZCZEPANKIEWICZ BRUCE G; PERNI ROBERT B 权利人:KOPPETSCH KARSTEN; SZCZEPANKIEWICZ BRUCE G; PERNI ROBERT B; GLAXOSMITHKLINE LLC 摘要:Provided herein is a simple, one-step, non-enzymatic synthesis of O-Acetyl-ADP-ribose (OAADPR) from NAD and sodium acetate in acetic acid. The extension of this reaction to other carboxylic acids, demonstrates that the reaction between NAD, and NAD analogs produces mixtures of the corresponding 2′- and 3′-carboxylic esters. Included are O-carboxyl-ADP-ribose compounds and corresponding methods of synthesis (e.g., O-propionyl-ADP-ribose, O-succinyl-ADP-ribose, O-malonyl-ADP-ribose), as well as non-adenosine nucleoside compounds.
专利号:US-2024024489-A1 优先权日:2020-11-20 标 题:Protected disaccharides, their process of preparation and their use in the synthesis of zwitterionic oligosaccharides, and conjugates thereof 发明人:MULARD LAURENCE; DHARA DEBASHIS; PFISTER HELENE; PAOLETTI JULIE; PHALIPON ARMELLE; GUERREIRO-INVERNO CATHERINE 权利人:PASTEUR INSTITUT 摘要:The present invention provides zwitterionic oligosaccharides, in particular fragments of the surface polysaccharides from Shigella sonnei and Shigella sonnei conjugates comprising them. The present invention also provides protected disaccharides, their process of preparation and their use in the synthesis of zwitterionic oligosaccharides, and conjugates thereof, the disaccharide repeating unit of Shigella sonnei being: (I)
专利号:US-2024240209-A1 优先权日:2021-04-20 标 题:Synthesis of enantiopure cis-a-irone from a renewable carbon source 发明人:CHEN XIXIAN; ZHANG CONGQIANG; T REHKA; SHUKAL SUDHA; SMITH DEREK; ANDRÉ ISABELLE; JEREMY ESQUE 权利人:AGENCY SCIENCE TECH & RES; INSTITUT NATIONAL DE RECH POUR L AGRICULTURE LALIMENTATION ET LENVIRONMENT; CENTRE NAT RECH SCIENT; INSTITUT NAT DES SCIENCES APPLIQUEES DE TOULOUSE 摘要:Synthesis of enantiopure cis-α-irone from a renewable carbon source Disclosed herein are natural and synthetic enzymes capable of performing a method of producing cis-α-irone. The method comprises providing an enzyme capable of converting psi-ionone to cis-α-irone; and contacting the enzyme and psi-ionone under suitable conditions to produce cis-α-irone. The enzyme may be a methyltransferase from Streptomyces albireticuli (SaMT), a promiscuous bifunctional methyltransferase/cyclase (pMT1) enzyme from Streptomyces, or a modified pMT1 enzyme with at least one substitution. The enzymes allow the in-vivo and in-vitro production of cis-α-irone including the use of glucose as feedstock for the biotransformation into cis-α-irone.
专利号:US-11858953-B2 优先权日:2018-04-04 标 题:Compositions and methods for synthesis of phosphorylated molecules 发明人:CHAPUT JOHN; LIAO JEN-YU; BALA SAIKAT 权利人:UNIV CALIFORNIA 摘要:The invention provides compositions and methods for synthesis of phosphorylated organic compounds, including nucleoside triphosphates.
专利号:US-2023174567-A1 优先权日:2020-05-22 标题:Synthesis of fluorinated nucleotides 发明人:ARMIGER TRAVIS; BELYK KEVIN M; BENKOVICS TAMAS; CHUNG CHEOL K; JI CHEN YINING; JOHNSON HEATHER CLAIRE; KLAPARS ARTIS; LIU ZHIJIAN; LIU ZHUQING; MOORE JEFFREY C; NEEL ANDREW J; PENG FENG; RUMMELT STEPHAN M; SALEHI MARZUARANI NASTARAN; SHERRY BENJAMIN D; SONG ZHIGUO JAKE; TURNBULL BEN WILLIAM HULME; WANG LU; XU FENG 权利人:MERCK SHARP & DOHME LLC 摘要:The present invention relates to efficient processes useful in the preparation of fluorinated nucleosides, such as (2S,3R,4S,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-fluoro-4-hydroxy-2-(mercaptomethyl)tetrahydrofuran-3-yl dihydrogen phosphate, also known as 3′-fluoro-thio-guanosine monophosphate or 3′-F-thio-GMP. Such fluorinated nucleosides may be useful as a biologically active compound and or as an intermediate for the synthesis of more complex biologically active compounds. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation. (I)
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