临床前CDMO研发筛选相关化合物

CDMO是Contract Development and Manufacturing Organization的缩写，即合同定制研发生产组织。它是一种为制药企业及生物技术公司提供医药（特别是创新药）工艺研发及制备、工艺优化、放大生产、注册和验证批生产以及商业化生产等定制服务的机构. 在传统代工基础上增加了研发和工艺优化能力，是高技术壁垒的工艺研发能力与规模生产能力的深度结合. 1, 工艺开发与优化：创新性合成路线设计、工艺参数优化. 2, 中试放大：实验室工艺向规模化生产的转化 3, 注册批生产：支持客户新药申报的验证批生产. 4, 商业化生产：药品上市后的大规模生产供应. 全球医药CDMO行业保持较高景气度。根据弗若斯特沙利文预测：2026年全球CDMO市场规模：预计达1,189亿美元 2033年全球CDMO市场规模：预计达3,385亿美元. CDMO作为医药产业链专业化分工的产物，已经从单纯的CMO代工模式升级为"研发+生产"一体化的高附加值服务。当前，在多肽、ADC、CGT等新型药物赛道的驱动下，全球及中国CDMO市场保持高速增长。中国CDMO企业凭借完整的供应链体系、工程师红利和一体化服务能力，全球市占率有望持续提升，行业正从"成本优势"竞争迈向"体系优势"竞争的新阶段。
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临床前CDMO研发化合物筛选

CAS: 1070-11-7

Ethambutol 2HCl

中文名称: 盐酸乙胺丁醇
CAS号:1070-11-7
分子式: C10H24N2O2.2HCl 分子量: 277.23
产品形式: Dihydrochloride
研发状态: Recruiting
研发用途: Tuberculosis Active; Breastfeeding; Tuberculosis
研究机构: University of Liverpool; Infectious Diseases Institute Makerere University College of Health Sciences
研发日期: January 20 2022
研发阶段: --
Ethambutol 2HCl (CL40881) is a bacteriostatic antimycobacterial agent, which obstructs the formation of cell wall by inhibiting arabinosyl transferases.

CAS: 107007-99-8

Granisetron HCl

中文名称:盐酸格拉司琼
CAS号:107007-99-8
分子式: C18H24N4O.HCl 分子量: 348.87
产品形式: Hydrochloride
研发状态: Completed
研发用途: 1mg Vs 3 mg of Granisetron
研究机构: Cairo University; Mohamed Yousry Mohamed; Tamer Fayez Safan; Tamer Mohamed Khair; Mohamed Ahmed A. M.D.; Islam Mohamed Sayed
研发日期: January 8 2021
研发阶段: Phase 3
Granisetron is a serotonin 5-HT3 receptor antagonist,used to treat chemotherapy-induced nausea and vomiting.

CAS: 1069-66-5

Valproic Acid (NSC 93819) sodium salt

中文名称:丙戊酸钠
CAS号:1069-66-5
分子式: C8H15NaO2 分子量: 166.19
产品形式: Sodium salt
研发状态: Recruiting
研发用途: Solid Tumor Adult
研究机构: Virginia Commonwealth University; Puma Biotechnology Inc.
研发日期: May 1 2019
研发阶段: Phase 1 : Phase 2
Valproic Acid sodium salt (NSC 93819, Sodium valproate) is a HDAC inhibitor by selectively inducing proteasomal degradation of HDAC2, used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. Valproic acid induces Notch1 signaling in small cell lung cancer (SCLC) cells. Valproic acid is under investigation for treatment of HIV and various cancers. Valproic acid (VPA) induces autophagy and mitophagy by upregulation of BNIP3 and mitochondrial biogenesis by upregulating PGC-1α.

CAS: 106685-40-9

Adapalene

中文名称:阿达帕林
CAS号:106685-40-9
分子式: C28H28O3 分子量: 412.52
产品形式: free base
研发状态: Completed
研发用途: Acne Vulgaris
研究机构: University of California Davis
研发日期: Oct-15
研发阶段: Early Phase 1
Adapalene (CD-271) is a dual RAR and RXR agonist, used in the treatment of acne.

CAS: 106635-80-7

Tafenoquine

中文名称:他非诺喹
CAS号:106635-80-7
分子式: C24H28F3N3O3 分子量: 463.49
产品形式: Free base
研发状态: Withdrawn
研发用途: Healthy Lactating Women
研究机构: University of Oxford; Mahidol Oxford Tropical Medicine Research Unit
研发日期: July 1 2023
研发阶段: Phase 4
Tafenoquine (WR 238605) is an 8-aminoquinoline, used as an anti-malarial prophylactic agent.

CAS: 1066-17-7

Colistin

中文名称:抗敌素
CAS号:1066-17-7
分子式: C52H98N16O13 分子量: 1155.43
产品形式: free base
研发状态: Not yet recruiting
研发用途: Hospital-acquired Bacterial Pneumonia; Ventilator-associated Bacterial Pneumonia
研究机构: Omnix Medical Ltd
研发日期: Jan-24
研发阶段: Phase 2
Colistin(Polymyxin E), a cyclic polypeptide antibiotic synthesized by Bacillus polymyxa subspecies colistinus Koyama, exerts antimicrobial activity by targeting at the bacterial cell membrane.