临床前CDMO研发筛选相关化合物

CDMO是Contract Development and Manufacturing Organization的缩写，即合同定制研发生产组织。它是一种为制药企业及生物技术公司提供医药（特别是创新药）工艺研发及制备、工艺优化、放大生产、注册和验证批生产以及商业化生产等定制服务的机构. 在传统代工基础上增加了研发和工艺优化能力，是高技术壁垒的工艺研发能力与规模生产能力的深度结合. 1, 工艺开发与优化：创新性合成路线设计、工艺参数优化. 2, 中试放大：实验室工艺向规模化生产的转化 3, 注册批生产：支持客户新药申报的验证批生产. 4, 商业化生产：药品上市后的大规模生产供应. 全球医药CDMO行业保持较高景气度。根据弗若斯特沙利文预测：2026年全球CDMO市场规模：预计达1,189亿美元 2033年全球CDMO市场规模：预计达3,385亿美元. CDMO作为医药产业链专业化分工的产物，已经从单纯的CMO代工模式升级为"研发+生产"一体化的高附加值服务。当前，在多肽、ADC、CGT等新型药物赛道的驱动下，全球及中国CDMO市场保持高速增长。中国CDMO企业凭借完整的供应链体系、工程师红利和一体化服务能力，全球市占率有望持续提升，行业正从"成本优势"竞争迈向"体系优势"竞争的新阶段。
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临床前CDMO研发化合物筛选

CAS: 149845-06-7

Saquinavir Mesylate

中文名称:甲磺酸沙奎那韦
CAS号:149845-06-7
分子式: C38H50N6O5.CH4O3S 分子量: 766.95
产品形式: mesylate salt
研发状态: Withdrawn
研发用途: Saquinavir/Ritonavir BID or Lopinavir/Ritonavir BID
研究机构: The HIV Netherlands Australia Thailand Research Collaboration
研发日期: Phase 2; Phase 3
研发阶段:
Saquinavir mesylate (Ro 31-8959/003) is a potent inhibitor of HIV Protease used in antiretroviral therapy. It blocks proteolysis of polyproteins containing either wild-type or single-chain dimer retroviral proteinase (PR).

CAS: 14976-57-9

Clemastine (HS-592) fumarate

中文名称:富马酸氯马斯汀
CAS号:14976-57-9
分子式: C21H26ClNO.C4H4O4 分子量: 459.96
产品形式: Fumarate
研发状态: Not yet recruiting
研发用途: Demyelinating Diseases; Demyelination; Corpus Callosum; Multiple Sclerosis Brain Lesion; Multiple Sclerosis Acute and Progressive; Clinically Isolated Syndrome CNS Demyelinating
研究机构: University of California San Francisco
研发日期: March 1 2024
研发阶段: Phase 1 : Phase 2
Clemastine Fumarate (HS-592, Meclastine) is a selective histamine H1 receptor antagonist with IC50 of 3 nM. Clemastine stimulates autophagy via mTOR pathway.

CAS: 1496510-51-0

Relacorilant

中文名称:瑞拉可兰
CAS号:1496510-51-0
分子式: C27H22F4N6O3S 分子量: 586.56
产品形式: Free base
研发状态: Completed
研发用途: Cushing Syndrome; Neoplasms
研究机构: Corcept Therapeutics
研发日期: May 25 2022
研发阶段: Phase 1
Relacorilant (CORT125134) is a potent, selective and orally bioavailable glucocorticoid receptor antagonist, with a Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM for rat, human and monkey glucocorticoid receptor in cell-based assay, respectively.

CAS: 149647-78-9

Vorinostat (SAHA)

中文名称:伏立诺他
CAS号:149647-78-9
分子式: C14H20N2O3 分子量: 264.30
产品形式: free base
研发状态: Withdrawn
研发用途: HIV-1-infection; ART; Cd4+ Lymphocyte Deficiency; Lymphoid Tissue; Infection; Interleukin
研究机构: Masonic Cancer Center University of Minnesota
研发日期: July 15 2024
研发阶段: Phase 1
Vorinostat (SAHA,MK0683, Suberoylanilide hydroxamic acid, Zolinza) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay. Vorinostat abrogates productive HPV-18 DNA amplification.

CAS: 149-32-6

Erythritol

中文名称:赤藓糖醇
CAS号:149-32-6
分子式: C4H10O4 分子量: 122.12
产品形式: free base
研发状态: Completed
研发用途: IBS
研究机构: Örebro University Sweden
研发日期: March 26 2019
研发阶段: Not Applicable
Erythritol(meso-Erythritol) is a sugar alcohol used as low-calorie sweetener.

CAS: 1492952-76-7

Asciminib (ABL001)

中文名称:阿思尼布
CAS号:1492952-76-7
分子式: C20H18ClF2N5O3 分子量: 449.84
产品形式: free base
研发状态: Not yet recruiting
研发用途: CML Chronic Phase; Chronic Myeloid Leukemia Chronic Phase; Chronic Myeloid Leukemia BCR/ABL-Positive; Chronic Myeloid Leukemia
研究机构: Gruppo Italiano Malattie EMatologiche dell''Adulto; Fundacion Espanola para la Curacion de la Leucemia Mieloide Cronica
研发日期: Sep-24
研发阶段: Phase 2
Asciminib (ABL001) is a potent and selective allosteric ABL1 inhibitor with dissociation constant (Kd) of 0.5-0.8 nM and selectivity to the myristoyl pocket of ABL1.