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临床前CDMO研发化合物筛选
Silibinin (NSC 651520)
中文名称:水飞蓟宾A
CAS号:22888-70-6
分子式: C25H22O10 分子量: 482.44
产品形式: free base
研发状态: Completed
研发用途: Liver Diseases; Chronic Liver Disease
研究机构: Medica Sur Clinic & Foundation
研发日期: November 11 2016
研发阶段: --
Silibinin (NSC 651520, Silybin, Silibinin A, Silymarin I, Flavobin), the main flavonoid extracted from the milk thistle Silybum marianum, displays hepatoprotective properties in acute and chronic liver injury.
Miconazole Nitrate
中文名称:硝酸咪康唑
CAS号:22832-87-7
分子式: C18H14Cl4N2O.HNO3 分子量: 479.14
产品形式: Nitrate
研发状态: Completed
研发用途: Healthy
研究机构: University of Southern Denmark; Odense University Hospital
研发日期: Apr-08
研发阶段: Not Applicable
Miconazole (NSC 169434) Nitrate is an imidazole antifungal agent by inhibiting ergosterol biosynthesis and inducing ROS, used to treat vaginal yeast infections.
BAY 2666605
CAS号:2275774-60-0
分子式: C17H12F4N2O2 分子量: 352.28
产品形式: Free base
研发状态: Terminated
研发用途: Metastatic Melanoma and Other Solid Tumors
研究机构: Bayer
研发日期: April 15 2021
研发阶段: Phase 1
BAY 2666605 is an orally active phosphodiesterase 3A (PDE3A) and phosphodiesterase 3B (PDE3B) inhibitor with IC50s of 87 nM and 50 nM, respectively.
Emapunil (AC 5216)
中文名称:依马普尼
CAS号:226954-04-7
分子式: C23H23N5O2 分子量: 401.46
产品形式: Free Base
研发状态: Completed
研发用途: Anxiety Disorders
研究机构: Novartis Pharmaceuticals; Novartis
研发日期: Mar-05
研发阶段: Phase 2
Emapunil (AC-5216, 18 kiloDalton Translocator Protein, XBD173) is a novel mitochondrial benzodiazepine receptor/translocator protein (MBR/TSPO) ligand. Emapunil(AC-5216) showes high affinity for MBRs prepared from rat whole brain with Ki of 0.297 nM and IC50 of 3.04 nM and 2.73 nM at rat glioma cells and human glioma cells, respectively.
Cinacalcet
中文名称: 西那卡塞
CAS号:226256-56-0
分子式: C22H22F3N 分子量: 357.41
产品形式: Free Base
研发状态: Not yet recruiting
研发用途: Cervical Intraepithelial Neoplasia Grade 2
研究机构: European Institute of Oncology
研发日期: May 15 2024
研发阶段: --
Cinacalcet (AMG073, Sensipar, Cin) is an orally active, allosteric agonist of receptors for calcium (CaR) that increases the sensitivity of the CaR to Ca.
Mezigdomide (CC-92480)
CAS号:2259648-80-9
分子式: C32H30FN5O4 分子量: 567.61
产品形式: free base
研发状态: Completed
研发用途: Healthy Volunteers
研究机构: Celgene
研发日期: October 15 2020
研发阶段: Phase 1
Mezigdomide (CC-92480) is a novel protein degrader and a cereblon E3 ligase modulator (CELMoD) that has anti-myeloma activity.
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