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临床前CDMO研发化合物筛选
Tandutinib (MLN518)
中文名称:坦度替尼
CAS号:387867-13-2
分子式: C31H42N6O4 分子量: 562.70
产品形式: Free Base
研发状态: Withdrawn
研发用途: Glioblastoma Multiforme
研究机构: Millennium Pharmaceuticals Inc.
研发日期: Jun-09
研发阶段: Phase 1
Tandutinib (MLN518, CT53518, NSC726292) is a potent FLT3 antagonist with IC50 of 0.22 μM, also inhibits PDGFR and c-Kit, 15 to 20-fold higher potency for FLT3 versus CSF-1R and >100-fold selectivity for the same target versus FGFR, EGFR and KDR. Phase 2.
Chloroprocaine HCl
中文名称:盐酸氯普鲁卡因
CAS号:3858-89-7
分子式: C13H20Cl2N2O2 分子量: 307.22
产品形式: Hydrochloride
研发状态: Withdrawn
研发用途: Cesarean Section Complications; Pain
研究机构: Johns Hopkins University
研发日期: Jun-21
研发阶段: Phase 3
Chloroprocaine HCl is a local anesthetic during surgical procedures.
Sulindac
中文名称:舒林酸
CAS号:38194-50-2
分子式: C20H17FO3S 分子量: 356.41
产品形式: free base
研发状态: Withdrawn
研发用途: Focus of Study: Drug Response Biomarkers Chemoprevention Neoplasms
研究机构: Cancer Prevention Pharmaceuticals Inc.; University of Arizona
研发日期: Mar-14
研发阶段: Phase 2
Sulindac(MK-231) is a non-steroidal COX inhibitor, which potently inhibits prostaglandin synthesis, used in the treatment of acute or chronic inflammatory conditions.
Streptomycin sulfate
中文名称:硫酸链霉素
CAS号:3810-74-0
分子式: 2C21H39N7O12.3H2SO4 分子量: 1457.38
产品形式: 1.5 Sulfate
研发状态: Completed
研发用途: Tuberculosis Multidrug-Resistant
研究机构: Foundation for Innovative New Diagnostics Switzerland
研发日期: April 16 2021
研发阶段: --
Streptomycin sulfate(Phytomycin) is a sulfate salt of streptomycin that is a protein synthesis inhibitor.
Bosutinib (SKI-606)
中文名称:伯舒替尼
CAS号:380843-75-4
分子式: C26H29Cl2N5O3 分子量: 530.45
产品形式: free base
研发状态: Completed
研发用途: Myeloid Leukemia
研究机构: Pfizer
研发日期: October 8 2021
研发阶段: --
Bosutinib (SKI-606) is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM in cell-free assays, respectively. Bosutinib also effectively decreases the activity of PI3K/AKT/mTOR, MAPK/ERK and JAK/STAT3 signaling pathways by blocking the phosphorylation levels of p-ERK, p-S6, and p-STAT3. Bosutinib promotes autophagy.
Tenofovir alafenamide fumarate
中文名称:替诺福韦艾拉酚胺富马酸盐
CAS号:379270-38-9
分子式: C25H33N6O9P 分子量: 592.54
产品形式: Fumarate
研发状态: Not yet recruiting
研发用途: Healthy Volunteer; Weight Gain; Metabolic Effects; Integrase Strand Transfer Inhibitors
研究机构: National Institute of Allergy and Infectious Diseases (NIAID); National Institutes of Health Clinical Center (CC)
研发日期: May 15 2024
研发阶段: Phase 2
Tenofovir alafenamide (TAF, GS-7340) fumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.
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