CAS: 3858-89-7; Chloroprocaine Hcl

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CAS号2457-76-3 4-氨基-2-氯苯甲酸 | CAS号14426-20-1 二乙氨基乙醇盐酸盐

2-(Diethylamino)Ethyl 2-Chloro-4-Nitrobenzoate置于铁粉,氯化铵体系中,用 水 作为反应溶剂,化学反应生成 盐酸氯普鲁卡因
参考文献:盐酸氯普鲁卡因制备方法
标题:盐酸氯普鲁卡因制备方法
摘要:本发明属于有机药物合成技术领域,具体涉及盐酸氯普鲁卡因制备方法,包括,步骤一:将邻氯对硝基苯甲酸和2‑二乙胺基乙醇反应原料加入二甲苯反应溶剂中,通过加入对甲苯磺酸或固载化液体酸或弱酸性金属盐作为催化剂,加热至回流,反应一定时间,后处理,得到硝基氯卡因的水溶液;步骤二:将所述硝基氯卡因的水溶液加入氯化铵,并加入铁粉,加热反应,后处理,得到盐酸氯普鲁卡因粗品;精制,得到盐酸氯普鲁卡因.本发明直接酯化反应时间短,生产周期减少了30%以上,成品总收率大于30%,能耗减少了25%以上.盐酸氯普鲁卡因含量不少于99.0%,有关物质不大于1.0%,残留溶剂(二甲苯)不超过0.1%,本发明的制备方法适用于工业化生产.

专利信息

专利号:WO-9925385-A1
优先权日:1997-11-17
标 题:A method of increasing nucleic acid synthesis with ultrasound
发明人：UNGER EVAN C; MCCREERY THOMAS; SADEWASSER DAVID
权利人:IMARX PHARMACEUTICAL CORP
摘要:The present invention is directed to a method of increasing nucleic acid synthesis in a cell comprising administering to the cell a therapeutically effective amount of ultrasound for a therapeutically effective time such that said administration of said ultrasound results in said increased nucleic acid synthesis. The nucleic acid sequence may comprise an endogenous sequence or an exogenous sequence.

专利号:US-9687428-B2
优先权日:2001-05-01
标题 :Hydrogel compositions for tooth whitening
发明人：SINGH PARMINDER; CLEARY GARY W; MUDUMBA SRI; FELDSTEIN MIKHAIL M; BAYRAMOV DANIR F
权利人:A V TOPCHIEV INST OF PETROCHEMICAL SYNTHESIS RUSSIAN ACAD OF SCIENCES; CORIUM INT INC; A V TOPCHIEV INST OF PETROCHEMICAL SYNTHESIS RUSSIAN ACAD OF SCIENCES
摘要:A composition is provided, wherein the composition comprises a water-swellable, water insoluble polymer, a blend of a hydrophilic polymer and a complementary oligomer capable of hydrogen bonding to the hydrophilic polymer, and a whitening agent, preferably a peroxide. The composition finds utility as a tooth whitening composition and is applied to the teeth in need of whitening, and then removed when the degree of whitening has been achieved. In certain embodiments, the composition is translucent. Methods for preparing and using the compositions are also disclosed.

专利号:US-2003138490-A1
优先权日:2001-09-08
标 题 :Synthesis and uses of polymer gel nanoparticle networks
发明人：HU ZHIBING; LU XIHUA; GAO JUN; PONDER BILL C; JOHN JOHN ST; MORO DANIEL G
摘要:Disclosed is a new class of nanostructured polymeric materials comprising polymer gel nanoparticles that are covalently bonded through functional groups on the surfaces of neighboring particles. These nanoparticles may be prepared as suspensions in an aqueous or, non-aqueous environment. These gels have two unique and different structural networks; the primary network comprises crosslinked polymer chains in each individual particle, while the secondary network is a system of crosslinked nanoparticles. Particular polymer gel nanoparticle network compositions disclosed herein may function as carriers for controlled delivery of pharmaceuticals or other chemical agents, gel sensors and other commercial applications.

专利号:CN-114702404-A
优先权日:2022-04-25
标 题 :A kind of method for promoting the synthesis of chloroprocaine impurity by microwave

专利号:US-7993390-B2
优先权日:2002-02-08
标 题:Implantable or insertable medical device resistant to microbial growth and biofilm formation
发明人：MILLER KATHLEEN M; BUCAY-COUTO WEENNA; LI JIANMIN
权利人:BOSTON SCIENT SCIMED INC
摘要:Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and/or a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents.

专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.