临床前CDMO研发筛选相关化合物

CDMO是Contract Development and Manufacturing Organization的缩写，即合同定制研发生产组织。它是一种为制药企业及生物技术公司提供医药（特别是创新药）工艺研发及制备、工艺优化、放大生产、注册和验证批生产以及商业化生产等定制服务的机构. 在传统代工基础上增加了研发和工艺优化能力，是高技术壁垒的工艺研发能力与规模生产能力的深度结合. 1, 工艺开发与优化：创新性合成路线设计、工艺参数优化. 2, 中试放大：实验室工艺向规模化生产的转化 3, 注册批生产：支持客户新药申报的验证批生产. 4, 商业化生产：药品上市后的大规模生产供应. 全球医药CDMO行业保持较高景气度。根据弗若斯特沙利文预测：2026年全球CDMO市场规模：预计达1,189亿美元 2033年全球CDMO市场规模：预计达3,385亿美元. CDMO作为医药产业链专业化分工的产物，已经从单纯的CMO代工模式升级为"研发+生产"一体化的高附加值服务。当前，在多肽、ADC、CGT等新型药物赛道的驱动下，全球及中国CDMO市场保持高速增长。中国CDMO企业凭借完整的供应链体系、工程师红利和一体化服务能力，全球市占率有望持续提升，行业正从"成本优势"竞争迈向"体系优势"竞争的新阶段。
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临床前CDMO研发化合物筛选

CAS: 540737-29-9

Tofacitinib (CP-690550) Citrate

中文名称: 枸橼酸托法替尼
CAS号:540737-29-9
分子式: C16H20N6O.C6H8O7 分子量: 504.49
产品形式: Citrate
研发状态: Enrolling by invitation
研发用途: Frontal Fibrosing Alopecia; Lichen Planopilaris
研究机构: Institute of Dermatology Thailand
研发日期: November 29 2023
研发阶段: Not Applicable
Tofacitinib citrate (CP-690550, Tasocitinib) is a novel inhibitor of JAK with IC50 of 1 nM, 20 nM and 112 nM against JAK3, JAK2, and JAK1, respectively. Tofacitinib citrate has anti-infection activity.

CAS: 54048-10-1

Etonogestrel

中文名称:依托孕烯
CAS号:54048-10-1
分子式: C22H28O2 分子量: 324.46
产品形式: free base
研发状态: Not yet recruiting
研发用途: Contraception; Pharmacogenomic Drug Interaction
研究机构: Yale University; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
研发日期: May-24
研发阶段: Phase 4
Etonogestrel (Implanon, Nexplanon, 3-Oxodesogestrel, 3-keto-Desogestrel) is a synthetic form of the naturally occurring female sex hormone progesterone. It binds to the cytoplasmic progesterone receptors in the reproductive system and subsequently activates progesterone receptor mediated gene expression.

CAS: 53902-12-8

Tranilast (SB 252218)

中文名称:曲尼司特
CAS号:53902-12-8
分子式: C18H17NO5 分子量: 327.33
产品形式: free base
研发状态: Recruiting
研发用途: Nasopharyngeal Carcinoma; Recurrent Cancer
研究机构: Jian Guan; Nanfang Hospital Southern Medical University
研发日期: July 20 2022
研发阶段: Phase 2
Tranilast (SB 252218, MK-341, Rizaben, MK 341, Tranpro) is an antiallergic drug by inhibiting lipid mediator and cytokine release from inflammatory cells, used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis.

CAS: 53-86-1

Indomethacin (NSC-77541)

中文名称: 吲哚美辛
CAS号:53-86-1
分子式: C19H16ClNO4 分子量: 357.79
产品形式: free base
研发状态: Completed
研发用途: Pancreatitis; Cholangiopancreatography Endoscopic Retrograde; Indomethacin
研究机构: The First Affiliated Hospital of Soochow University
研发日期: November 1 2022
研发阶段: Not Applicable
Indomethacin (NSC-77541, Indometacin) is a nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively, used to reduce fever, pain, stiffness, and swelling.

CAS: 53-84-9

NAD+

中文名称: 辅酶I
CAS号:53-84-9
分子式: C21H27N7O14P2 分子量: 663.43
产品形式: free base
研发状态: Recruiting
研发用途: Smooth Muscle Dysfunction Syndrome (SMDS)
研究机构: The University of Texas Health Science Center Houston
研发日期: March 6 2024
研发阶段: Phase 1
NAD+ (β-DPN, β-NAD, β-Nicotinamide Adenine Dinucleotide,nicotinamide adenine dinucleotide) is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.

CAS: 537-42-8

Pterostilbene

中文名称:紫檀芪
CAS号:537-42-8
分子式: C16H16O3 分子量: 256.30
产品形式: free base
研发状态: Completed
研发用途: Acute Kidney Injury
研究机构: Massachusetts General Hospital; Elysium Health
研发日期: November 1 2017
研发阶段: Not Applicable
Pterostilbene is a natural dietary compound and the primary antioxidant component of blueberries. It has been implicated in anticarcinogenesis, modulation of neurological disease, anti-inflammation, attenuation of vascular disease, and amelioration of diabetes.