项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

Fluocortin butyl, SH-K-203

Chemical Name: 6alpha-Fluoro-11beta-hydroxy-16alpha-methyl-3,20-dioxopregna-1,4-dien-21-oic acid butyl ester
CAS No. 41767-29-7
项目整合开发状态: Biological Testing
项目研究机构:
合成路线:The reaction of 6...
参考文献标题:
文献作者:Laurent,H.; et al.
参考来源:DE 2204361; GB 1387911

SSR-182289A, SSR-182289

Chemical Name: N-[3-[N-[4-(5-Aminopyridin-2-yl)-1(S)-[4-(difluoromethylene)piperidin-1-ylcarbonyl]butyl]sulfamoyl]biphenyl-2-yl]acetamide hydrochloride
CAS No. 362615-85-8, 363151-21-7 (free base)<...
参考文献标题:N-(Heterocyclyl)benzene or pyridine sulphonamides as antithrombotic agents and anticoagulants
文献作者:Cremer,G.; Lassalle,G.; Altenburger,J.-M.; Matrougui,M.(Sanofi-Synthabo)
参考来源:EP 1268469; WO 0170736

Disobutamide, SC-31828

Chemical Name: 2-(2-Chlorophenyl)-4-(diisopropylamino)-2-[2-(1-piperidinyl)ethyl]butyramide
CAS No. 68284-67-3
项目整合开发状态: Not Determined
项目研究机构:
合成路线:The reaction of 2-chlorophenylacetonit...
参考文献标题:
文献作者:Renbarger,J.J.; Yonan,P.K.
参考来源:BE 864822; DE 2810143; FR 2383163; JP 78121737; US 4107205; US 4153797; ZA 7801429

BIBT-0871

Chemical Name: 2-[1-[1-[2-(4-Amidinophenylaminomethyl)-1-methyl-1H-benzimidazol-5-yl]cyclopropyl]-1-(2-pyridyl)methylideneaminooxy]acetic acid ethyl ester
CAS No. 335612-86-7
项目整合开发状态: Preclinic...
参考文献标题:Benzimidazoles,production thereof and use thereof as medicaments
文献作者:Kauffmann,I.; Ries,U.; Priepke,H.; Hauel,N.; Stassen,J.M.; Nar,H.; Wienen,W.(Boehringer Ingelheim Pharma KG)
参考来源:DE 19829964; EP 1095025; WO 0001704

BIBR-1109

Chemical Name: 4-[1-Methyl-5-(2-methyl-1H-benzimidazol-1-ylmethyl)-1H-benzimidazol-2-ylmethylamino]benzamidine
CAS No. 335612-87-8, 253431-01-5 (monoHCl)
项目整合开发状态: Preclinical
项目研究机构: Boehrin...
参考文献标题:Benzimidazoles,production thereof and use thereof as medicaments
文献作者:Kauffmann,I.; Ries,U.; Priepke,H.; Hauel,N.; Stassen,J.M.; Nar,H.; Wienen,W.(Boehringer Ingelheim Pharma KG)
参考来源:DE 19829964; EP 1095025; WO 0001704

新产品编号:857953

Chemical Name: 4-[1-(Furo[3,2-c]pyridin-2-yl)-1-methylethyl]-1-[2(S)-hydroxy-4(R)-[N-[3(S)-hydroxy-3,4-dihydro-2H-1-benzopyran-4(S)-yl]carbamoyl]-5-phenylpentyl]-N-(2,2,2-trifluoroethyl)piperazine-2(S...
参考文献标题:gamma-Hydroxy-2-(fluoroalkylaminocarbonyl)-1-piperazinepentanamides as HIV protease inhibitors
文献作者:Askin,D.; Rano,T.A.; Tata,J.R.; Chapman,K.T.; Raghavan,S.; Kevin,N.J.; Varsolona,R.J.; Lu,Z.; Hoerrner,R.S.; Zhang,F.; Duffy,J.L.; Cheng,Y.; Huening,T.; Kirk,B.A.; Fleitz,F.J.; Petrillo,D.E.; et al.(Merck & Co.,Inc.)
参考来源:EP 1242426; WO 0138332

新产品编号:884847

Chemical Name: 2-[3-(Biphenyl-4-yl)-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl]-N,N-dimethylacetamide
CAS No. 358625-66-8
项目整合开发状态: Preclinical
项目研究机构: Novartis (Originator)
合成路线:Conden...
参考文献标题:The effect of 1,3-diaryl-[1H]-pyrazole-4-acetamides on glucose utilization in ob/ob mice
文献作者:Bebernitz,G.R.; Argentieri,G.; Battle,B.; Brennan,C.; Balkan,B.; Burkey,B.F.; Eckhardt,M.; Gao,J.; Kapa,P.; Strohschein,R.J.; Schuster,H.F.; Wilson,M.W.; Xu,D.D.
参考来源:J Med Chem 2001,44(16),2601

O-1924

Chemical Name: (1S,2S,3R,5R,7R)-3-(3,4-Dichlorophenyl)-7-hydroxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid methyl ester
CAS No. 211047-07-3, 187963-42-4 (racemate)
项目整合开发状态: Biologica...
参考文献标题:Synthesis of 6- and 7-hydroxy-8-azabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters
文献作者:Meltzer,P.C.; Wang,B.B.; Chen,Z.; Blundell,P.; Jayaraman,M.; Gonzalez,M.D.; George,C.; Madras,B.K.
参考来源:J Med Chem 2001,4(16),2619

MC-5723

Chemical Name: 1-Hydroxy-1-[5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl]methylphosphonic acid
CAS No. 357966-09-7
项目整合开发状态: Preclinical
项目研究机构: Medicure (Originator)
合成路线:Addition of ...
参考文献标题:Cardioprotective phosphonates and malonates
文献作者:Haque,W.(Medicure Inc.)
参考来源:WO 0164692

PX-117794

Chemical Name: 3-[4-(3,4-Dimethoxyphenylsulfonamido)phenyl]-2-propenohydroxamic acid
CAS No. 342372-36-5, 414872-01-8 ((E)-isomer)
项目整合开发状态: Preclinical
项目研究机构: MethylGene (Originator), TopoT...
参考文献标题:Inhibitors of histone deacetylase
文献作者:Delorme,D.; Ruel,R.; Lavoie,R.; Thibault,C.; Abou-Khalil,E.(MethylGene Inc.)
参考来源:EP 1233958; JP 2003514904; WO 0138322