项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Alendronate sodium, Alendronic acid sodium salt, L-670452, MK-0217, GTH-42(diNa salt), G-704650(trihydrate), MK-217, AHButBP, AHBuBP, Fosamac, Bonalon, Teiroc(former Brand Name), Onclast, Alendros, Fosamax

阿仑膦酸阿仑膦酸钠,三水合物 Chemical Name: (4-Amino-1-hydroxybutylidene)bisphosphonic acid sodium salt
CAS No. 66376-36-1 (free acid), 121268-17-5 (triNa salt, trihydrate)
项目整合开发状态: Launched-1993
项目研究机构...
参考文献标题:Novel process for preparing alendronic acid
文献作者:Lidor-Hadas,R.; et al.(Teva Pharmaceutical Industries Ltd.; Teva Pharmaceuticals USA,Inc.)
参考来源:WO 0049026

Acrivastine, BW-825C, Semprex

阿伐斯汀Chemical Name: (E,E)-3-[6-[1-(4-Methylphenyl)-3-(1-pyrroldidinyl)-1-propenyl]-2-pyridinyl]-2-propenoic acid; (E)-6-[(E)-3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]-2-pyridineacrylic acid
CAS No. 878...
参考文献标题:Synthesis of deuterium-labeled acrivastine and an acrivastine metabolite
文献作者:Thompson,J.B.; Blake,K.W.; McNutt,R.W.
参考来源:J Label Compd Radiopharm 1995,36(10),973

Azithromycin, DCH3, XZ-450, CP-62993, Zentavion, Toraseptol, Vinzam, Zithromac, Zitromax Avium 600, Zitromax, Zithromax, Sumamed

阿奇霉素阿奇霉素二水合物Chemical Name: 9-Deoxo-9a-aza-9a-methyl-9a-homoerythromycin A ; [2R-(2R*,3S*,4R*,5R*,8R*,10R*,11R*,12S*,13S*,14R*)]-13-[(2,6-Dideoxy-3C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy]-2...
参考文献标题:N-Methyl 11-aza-10-deoxo-10-dihydroerythromycin A,intermediates therefor
文献作者:Bright,G.M.(Pfizer Inc.)
参考来源:EP 0101186; JP 1193292; US 4474768

Abaperidone hydrochloride, FI-8602.HCl

阿巴哌酮 Chemical Name: 7-[3-[4-(6-Fluorobenz-1,2-isoxazol-3-yl)piperidin-1-yl]propoxy]-3-(hydroxymethyl)-4H-1-benzopyran-4-one hydrochloride
CAS No. 183849-45-8, 183849-43-6 (free base)
项目整合开发状态: ...
参考文献标题:4-(6-Fluoro-1,2-benzisoxazolyl)-1-piperidinyl-propoxy-chromen-4-one derivs.,their preparation and their use in the treatment of psychosis,schizophrenia and anxiety
文献作者:Foguet,R.; Anglada,L.; Bol髎,J.; Ortiz,J.; Sacrist醤,A.; Castell? J.M.(Ferrer Internacional SA)
参考来源:EP 0765323; ES 2101646; ES 2103237; JP 1998501557; US 5736558; WO 9632389

Aspoxicillin, TA-058, Doyle

阿扑西林Chemical Name: N4-Methyl-D-aspariginylamoxicillin; 6beta-[2(R)-[2(R)-Amino-4-(methylamino)-4-oxobutyramido]-2-phenylacetamido]penicillanic acid
CAS No. 63358-49-6, 63329-59-9 (stereoisomer) 参考文献标题:Penicillins and processes for preparing the same
文献作者:Kawazu,M.; et al.(Tanabe Seiyaku Co.,Ltd.)
参考来源:DE 2638067; FR 2323384; NL 7610151; US 4053609

Alacepril, DU-1219, Cetapril

阿拉普利Chemical Name: N-[3-(Acetylsulfanyl)-2(S)-methylpropionyl]-L-prolyl-L-phenylalanine
CAS No. 74258-86-9
项目整合开发状态: Launched-1988
项目研究机构: Dainippon Pharmaceutical (Originator), Mochida (Lic...
参考文献标题:1-(3-Mercapto-2-methylpropanoyl)prolylamino acid derivs.
文献作者:Sawayama,T.; Kinugasa,H.; Nishimura,A.; Takeyama,K.; Hosoki,K.(Dainippon Pharmaceutical Co.,Ltd.)
参考来源:JP 1980009058; US 4248883

Alamifovir, LY-582563, MCC-478

阿拉氟韦Chemical Name: 2-[2-Amino-6-(4-methoxyphenylsulfanyl)-9H-purin-9-yl]ethoxymethylphosphonic acid bis(2,2,2-trifluoroethyl) diester
CAS No. 193681-12-8, 193681-35-5 (monoHCl)
项目整合开发状态: Phase ...
参考文献标题:Phosphonate nucleotide cpds.
文献作者:Ubasawa,M.; Kamiya,N.; Takashima,H.; Yuasa,S.; Ueda,N.; Sekiya,K.(Mitsubishi Chemical Corp.)
参考来源:EP 0785208; US 5840716

Acitretin, Etretin, Ro-10-1670, Ro-10-1670/000, Tigason, Soriatane, Neotigason

阿维A酸Chemical Name: (all-E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid
CAS No. 55079-83-9
项目整合开发状态: Launched-1989
项目研究机构: Connetics (Proprietary), Chugai (Or...
参考文献标题:RO 10-1670
文献作者:Castar,J.; Hillier,K.
参考来源:Drugs Fut 1977,2(11),763

Almotriptan, PNU-180638, LAS-31416, Almogran, Axert

阿莫曲坦Chemical Name: 3-[2-(Dimethylamino)ethyl]-5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indole
CAS No. 154323-57-6
项目整合开发状态: Launched-2000
项目研究机构: Almirall Prodesfarma (Originator), Kwizda (Marke...
参考文献标题:Indol derivs.for the treatment of migraine
文献作者:Fernandez Forner,D.; Puig Duran,C.; Prieto Soto,J.; Vega Noverola,A.; Moragues Mauri,J.(Almirall Prodesfarma,SA)
参考来源:EP 0605697; JP 1994511261; US 5565447; WO 9402460

Acipimox, K-9321, Olbemox, Olbetam

阿西莫司Chemical Name: 5-Methylpyrazinecarboxylic acid 4-oxide
CAS No. 51037-30-0
项目整合开发状态: Launched-1985
项目研究机构: Pfizer (Originator)
合成路线:By oxidation of 5-methylpyrazin-2-carboxylic acid (I...
参考文献标题:Acipimox
文献作者:de Angelis,L.; Castar,J.; Blancafort,P.; Serradell,M.N.
参考来源:Drugs Fut 1979,4(8),545