Alacepril, DU-1219, Cetapril
阿拉普利Chemical Name: N-[3-(Acetylsulfanyl)-2(S)-methylpropionyl]-L-prolyl-L-phenylalanine
CAS No. 74258-86-9
项目整合开发状态: Launched-1988
项目研究机构: Dainippon Pharmaceutical (Originator), Mochida (Licensee)
合成路线:The condensation of 1-(D-3-acetylthio-2-methylpropanoyl)-L-proline (I) with L-phenylalanine tert-butyl ester (II) by means of N-methylmorpholine and phenyl chloroformate in THF gives 1-(D-3-acetyl-thio-2-methylpropanoyl)-L-prolyl-L-phenylalanine tert-butyl ester (III),which is hydrolyzed with trifluoroacetic acid in anisole.
📌 参考资料/链接：
参考文献标题:1-(3-Mercapto-2-methylpropanoyl)prolylamino acid derivs.
文献作者:Sawayama,T.; Kinugasa,H.; Nishimura,A.; Takeyama,K.; Hosoki,K.(Dainippon Pharmaceutical Co.,Ltd.)
参考来源:JP 1980009058; US 4248883
📄 详细内容
合成路线:The condensation of 1-(D-3-acetylthio-2-methylpropanoyl)-L-proline (I) with L-phenylalanine tert-butyl ester (II) by means of N-methylmorpholine and phenyl chloroformate in THF gives 1-(D-3-acetyl-thio-2-methylpropanoyl)-L-prolyl-L-phenylalanine tert-butyl ester (III),which is hydrolyzed with trifluoroacetic acid in anisole.
参考文献标题:Alacepril
文献作者:Castar,J.; Mannhold,R.
参考来源:Drugs Fut 1986,11(5),357
产品链接: CAS No. 74258-86-9››