项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Clopipazan mesylate, SK&F-69634

氯哌帕生 Chemical Name: 4-(2-Chloro-9H-xanthen-9-ylidene)-1-methylpiperidine methanesulfonate
CAS No. 60086-22-8, 60085-78-1 (free base)
项目整合开发状态: Not Determined
项目研究机构:
合成路线:The reaction of...
参考文献标题:
文献作者:
参考来源:BE 835224; DE 2549841; FR 2290202; JP 7670768; JP 7783854; NL 7512974; ZA 7506550

Muzolimine, Bay-g-2821

氯唑啉胺Chemical Name: 5-Amino-2-[1-(3,4-dichlorophenyl)ethyl]-2,4-dihydro-3H-pyrazol-3-one
CAS No. 55294-15-0
项目整合开发状态: Biological Testing
项目研究机构:
合成路线:By condensation of alpha-methyl-3,4-d...
参考文献标题:Muzolimine
文献作者:Castar,J.; Hillier,K.
参考来源:Drugs Fut 1977,2(6),387

Clodoxopone, LR-19731

氯氧喷Chemical Name: 4-(4-Chlorophenyl)-5-[2-(4-phenyl-1-piperazinyl)ethyl]-1,3-dioxol-2-one; 4-(p-Chlorophenyl)-5-beta-(N'-phenyl)piperazinoethyl-1,3-dioxol-2-one
CAS No. 71923-34-7, 71923-01-8 (diH...
参考文献标题:4-aryl-5-aminoalchil-1,3-dissol-2-oni,loro derivati,processi per la loro preparazione,e composizioni farmaceutche che li contengono
文献作者:Manghisi,E.; Porta,R.; Cascio,G.; Fregnan,G.(Lusofarmaco)
参考来源:BE 0874561

Cronidipine, LF-2.0254

氯硝地平Chemical Name: 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[8-(4-chlorophenyl)-8-aza-1,4-dioxaspiro[4.5]deca-2-ylmethyl] 5-methyl diester
CAS No. 113759-50-5
...
参考文献标题:Disymetric derivs.of 1,4-dihydropyridine-3,5-dicarboxylic acid,method of preparation and use in therapeutics
文献作者:Robin,J.; Pruneau,D.; Bellamy,F.(SORI)
参考来源:EP 0240398; FR 2596760; JP 1988017883; US 4806544

Chlortenoxicam, Lornoxicam, HN-10000, TS-110, Ro-13-9297, CLTX, Xefocam, Taigalor, Telos, Lorcam, Acabel, Xefo, Safem

氯诺昔康Chemical Name: 6-Chloro-4-hydroxy-2-methyl-N-(2-pyridyl)-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide
CAS No. 70374-39-9
项目整合开发状态: Launched-1997
项目研究机构: Nycomed Pharma (Origin...
参考文献标题:Thiazine derivs
文献作者:Pfister,R.; Zeller,P.; Binder,D.; Hromatka,O.(F.Hoffmann-La Roche AG)
参考来源:DE 2838851

Lonafarnib, Sch-66336, Sarasar

氯那法尼 4-{2-[4-(3,10-二溴-8-氯-6,11-二氢-5H-苯并[5,6]环庚并[1,2-b]吡啶-11-基)-1-哌啶基]-2-氧代乙基}-1-哌啶甲酰胺 Chemical Name: (+)-(R)-4-[2-[4-(3,10-Dibromo-8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)pi...
参考文献标题:Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative diseases
文献作者:Doll,R.J.; Kelly,J.M.; Njoroge,F.G.; Mallams,A.K.; Remiszewski,S.W.; Taveras,A.G.(Schering Corp.)
参考来源:EP 1019392; EP 1380581; JP 1999501671; WO 9723478

Salmeterol, Salmaterol, SN-408, GR-33343X, Inaspir

沙美特罗Chemical Name: (?-2-(Hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]phenol
CAS No. 89365-50-4
项目整合开发状态: Launched-1990
项目研究机构: GlaxoSmithKline (Originator)
合成路线:The ...
参考文献标题:Phenethanolamine derivs
文献作者:Skidmore,I.F.; Lunts,L.H.C.; Finch,H.; Naylor,A.(Glaxo Group Ltd.)
参考来源:BE 0899448; DE 3414752; ES 8609209; FR 2545482; GB 2140800; GB 2176476; JP 1988264443; JP 1994087800; US 4992474; US 5091422

Famotidine, MK-208, YM-11170, Quamatel, Pepdine, Famodil, Gastridin, Pepcid RPD, Pepcid AC, Pepcid, Pepdul, Pepcidine, Gaster

法莫替丁Chemical Name: 3-(2-Guanidinothiazol-4-ylmethylthio)-N-sulfamoylpropanamidine
CAS No. 76824-35-6
项目整合开发状态: Launched-1985
项目研究机构: Merck & Co. (Originator), Yamanouchi (Originator), Sigma-...
参考文献标题:Guanidinothiazole cpds.,process for preparation and gastric inhibiting compsns.containing them
文献作者:Isomura,Y.; Ishii,Y.; Ito,N.; Takeda,M.; Yanagisawa,I.; Hirata,Y.; Tsukamoto,S.(Yamanouchi Pharmaceutical Co.,Ltd.)
参考来源:US 4283408

Fandofloxacin hydrochloride, DW-116

泛斗沙星 Chemical Name: 6-Fluoro-1-(5-fluoropyridin-2-yl)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride
CAS No. 164150-85-0, 164150-99-6 (free base)
项目整合开发状态...
参考文献标题:Leukotriene B4 derivs.,methods of preparing them and their use as drugs
文献作者:Skuballa,W.; Buchmann,B.; Heindl,J.; Fr鰄lich,W.; Ekerdt,R.; Giesen,C.(Schering AG)
参考来源:EP 0741687; JP 1997511487; WO 9520564

Posizolid, AZD-2563

泼斯唑来Chemical Name: 3-[4-[1-[2(S),3-Dihydroxypropionyl]-1,2,3,6-tetrahydropyridin-4-yl]-3,5-difluorophenyl]-5(R)-(isoxazol-3-yloxymethyl)oxazolidin-2-one
CAS No. 252260-02-9, 252260-00-7 (diastereo...
参考文献标题:Oxazolidinone derivs.,process for their preparation and pharmaceutical compsns.containing them
文献作者:Gravestock,M.B.(AstraZeneca plc)
参考来源:EP 1082323; JP 2002517498; WO 9964417