Clopipazan mesylate, SK&F-69634
氯哌帕生 Chemical Name: 4-(2-Chloro-9H-xanthen-9-ylidene)-1-methylpiperidine methanesulfonate
CAS No. 60086-22-8, 60085-78-1 (free base)
项目整合开发状态: Not Determined
项目研究机构:
合成路线:The reaction of 1-methyl-4-chloropiperidine (I) with 2-chloro-9-xanthone (II) by means of Mg in THF gives 9-(1-methyl-4-piperidyl)-2-chloroxanthene-9-ol (III),which is dehydrated by reaction with p-sulfobenzoic anhydride (IV) in refluxing propionic acid and finally treated with methane sulfonic acid.
📌 参考资料/链接：
参考文献标题:
文献作者:
参考来源:BE 835224; DE 2549841; FR 2290202; JP 7670768; JP 7783854; NL 7512974; ZA 7506550
📄 详细内容
合成路线:The reaction of 1-methyl-4-chloropiperidine (I) with 2-chloro-9-xanthone (II) by means of Mg in THF gives 9-(1-methyl-4-piperidyl)-2-chloroxanthene-9-ol (III),which is dehydrated by reaction with p-sulfobenzoic anhydride (IV) in refluxing propionic acid and finally treated with methane sulfonic acid.
参考文献标题:Clopipazan Mesylate
文献作者:Blancafort,P.; Serradell,M.N.; Castar,J.; Owen,R.T.
参考来源:Drugs Fut 1981,6(1),15
产品链接: CAS No. 60086-22-8›› 产品链接: CAS No.60085-78-1››