项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Carvotroline hydrochloride, Wy-47791

卡伏曲林Chemical Name: 8-Fluoro-2-[2-(4-pyridyl)ethyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochloride
CAS No. 107266-08-0 (free base), 136777-43-0 (monoHCl)
项目整合开发状态: Phase I
项目研究机构: Wye...
参考文献标题:WY-47,791
文献作者:Abou-Gharbia,M.; Marquis,K.; Andree,T.
参考来源:Drugs Fut 1991,16(11),1008

Capecitabine, R-340, Ro-09-1978, Xeloda

卡培他滨Chemical Name: 5'-Deoxy-5-fluoro-N4-(pentyloxycarbonyl)cytidine; N-[1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamic acid pentyl ester
CAS No. 154361-50-9
项...
参考文献标题:N-Oxycarbonyl substd.5'-deoxy-5-fluorocytidines
文献作者:Arasaki,M.; Ishitsuka,H.; Kurama,I.; Miwa,M.; Murasaki,C.; Shimma,N.; Umeda,I.(F.Hoffmann-La Roche AG)
参考来源:EP 0602454; JP 1994211891; US 5472949

TAX-258, XRP-6258, RPR-116258A, TXD-258

卡巴他赛Chemical Name: [2aR[2aalpha,4beta,4abeta,6beta,9alpha(2R,3S),11beta,12alpha,12aalpha,12balpha]]-12b-Acetoxy-9-[3-(tert-butoxycarbonylamino)-2-hydroxy-3-phenylpropionyloxy]-12-(benzoyloxy)-11-hydro...
参考文献标题:Novel taxoids,preparation thereof and pharmaceutical compsns.containing same
文献作者:Bouchard,H.; Bourzat,J.-D.; Commer鏾n,A.(Aventis Pharma SA)
参考来源:EP 0817779; EP 0817780; FR 2732340; JP 1999500141; JP 1999502531; US 5889043; US 6372780; US 6387946; WO 9630355; WO 9630356

Carbovir, GR-90352, NSC-614846

卡巴韦Chemical Name: (?-2-Amino-9-[4beta-(hydroxymethyl)-2-cyclopenten-1beta-yl]-9H-purin-6(1H)-one; (?-9-[4beta-(Hydroxymethyl)-2-cyclopenten-1beta-yl]guanine; (?-Carbocyclic 2',3'-didehydro-2',3'-dideo...
参考文献标题:Synthesis of purine substd.cyclopentene derivs.
文献作者:Vince,R.; Peterson,M.L.; Lackey,J.W.; Mook,R.A.Jr.; Partridge,J.J.(GlaxoSmithKline plc)
参考来源:US 5126452

Carbuterol, Bronsecur

卡布特罗 [5-[2-(叔丁基氨基)-1-羟基乙基]-2-羟基苯基]脲盐酸盐 Chemical Name: N-[5-[2-(tert-Butylamino)-1-hydroxyethyl]-2-hydroxyphenyl]urea
CAS No. 34866-47-2, 34866-46-1 (hydrochloride)
项目整合开发状态: Biological Testing 参考文献标题:Carbuterol
文献作者:Castar,J.; Sungurbey,K.
参考来源:Drugs Fut 1976,1(9),412

Captopril, SQ-14225, Captril, Cesplon, Tensiomin, Capoten

卡托普利Chemical Name: 1-[(2S)-3-Mercapto-2-methyl-1-oxopropyl]-L-proline; N-[(2S)-3-Mercapto-2-methylpropionyl]-L-proline
CAS No. 62571-86-2
项目整合开发状态: Launched-1980
项目研究机构: Bristol-Myers Squibb ...
参考文献标题:Captopril
文献作者:Roberts,P.J.; Castar,J.
参考来源:Drugs Fut 1978,3(11),795

Carzelesin, NSC-619029, U-80244

卡折来新Chemical Name: (S)-N-[2-[1-(Chloromethyl)-8-methyl-5-(N-phenylcarbamoyloxy)-1,2,3,6-tetrahydrobenzo[1,2-b:4,3-b']dipyrrol-3-ylcarbonyl]-1H-indol-5-yl]-6-(diethylamino)benzofuran-2-carboxamide
C...
参考文献标题:Novel CC-1065 analogs
文献作者:Kelly,R.C.; Martin,D.G.; Aristoff,P.A.(Pharmacia Corp.)
参考来源:AU 8812290; EP 0340243; WO 8804659

Capimorelin, Capromorelin, CP-424391-18(tartrate), CP-424391

卡普瑞林酒石酸卡莫瑞林 Chemical Name: 2-Amino-N-[2-[3a(R)-benzyl-2-methyl-3-oxo-3,3a,4,5,6,7-hexahydro-2H-pyrazolo[4,3-c]pyridin-5-yl]-1(R)-(benzyloxymethyl)-2-oxoethyl]isobutyramide
CAS No. 193273-66-4, 193...
参考文献标题:Growth-hormone secretagogues
文献作者:Carpino,P.A.; Jardine,D.P.A.; Lefker,B.A.; Ragan,J.A.(Pfizer Inc.)
参考来源:EP 0869968; JP 1999501945; WO 9724369

Calcipotriene, Calcipotriol, BMS-181161, MC-903, Psorcutan, Divonex, Dovonex, Daivonex

卡泊三醇卡泊三醇 Chemical Name: 20(R)-[3'(S)-Cyclopropyl-3'-hydroxyprop-1'(E)-enyl]-1(S),3(R)-dihydroxy-9,10-secopregna-5(Z),7(E),10(19)-triene; 1(S),24(S)-Dihydroxy-22,23:26,27-tetradehydrovitamin D3
CAS...
参考文献标题:Synthesis of MC 903,a biologically active vitamin D metabolite analogue
文献作者:Calverley,M.J.
参考来源:Tetrahedron 1987,43(20),4609-19

Carprofen, Ro-20-5720, C-5720, Rimadyl, Imadyl

卡洛芬Chemical Name: (?-6-Chloro-alpha-methylcarbazole-2-acetic acid; (?-2-(6-Chlorocarbazol-2-yl)propanoic acid
CAS No. 53716-49-7
项目整合开发状态: Launched-1981
项目研究机构: GlaxoSmithKline (Originator) 参考文献标题:Carprofen
文献作者:Weetman,D.F.; Castar,J.
参考来源:Drugs Fut 1977,2(1),15