Carbuterol, Bronsecur
卡布特罗 [5-[2-(叔丁基氨基)-1-羟基乙基]-2-羟基苯基]脲盐酸盐 Chemical Name: N-[5-[2-(tert-Butylamino)-1-hydroxyethyl]-2-hydroxyphenyl]urea
CAS No. 34866-47-2, 34866-46-1 (hydrochloride)
项目整合开发状态: Biological Testing
项目研究机构:
合成路线:The reaction of 3-amino-4-benzyloxyacetophenone (I) with phosgene in toluene gives 3-isocyanate-4-benzyloxyacetophenone (II),which by reaction with ammonia in benzene yields 4-benzyloxy-3-ureidoacetophenone (III).The bromination of this product with Br2 in CHCl3 affords 4-benzyloxy-3-ureidophenacyl bromide (IV),amorphous product that is condensed with N-benzyl-N-tert-butylamine (V) in acetonitrile giving 4-benzyloxy-3-ureido-alpha-(N-benzyl-N-tert-butylamine)acetophenone hydrochloride (VI),m.p.220-1 C.This product is finally hydrogenated with H2 over Pd/C in methanol
📌 参考资料/链接：
参考文献标题:Carbuterol
文献作者:Castar,J.; Sungurbey,K.
参考来源:Drugs Fut 1976,1(9),412
📄 详细内容
合成路线:The reaction of 3-amino-4-benzyloxyacetophenone (I) with phosgene in toluene gives 3-isocyanate-4-benzyloxyacetophenone (II),which by reaction with ammonia in benzene yields 4-benzyloxy-3-ureidoacetophenone (III).The bromination of this product with Br2 in CHCl3 affords 4-benzyloxy-3-ureidophenacyl bromide (IV),amorphous product that is condensed with N-benzyl-N-tert-butylamine (V) in acetonitrile giving 4-benzyloxy-3-ureido-alpha-(N-benzyl-N-tert-butylamine)acetophenone hydrochloride (VI),m.p.220-1 C.This product is finally hydrogenated with H2 over Pd/C in methanol
参考文献标题:
文献作者:Kaiser,C.; et al.(Smith Kline French)
参考来源:DE 2106620
产品链接: CAS No. 34866-47-2›› 产品链接: CAS No.34866-46-1››