项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

MOSE

二-beta-(吗啉基乙基)硒醚Chemical Name: 4,4'-(Selenodi-2,1-ethanediyl)bismorpholine dihydrochloride; Bis(beta-morpholinoethyl)selenide dihydrochloride
CAS No. 83616-20-0, 73511-88-3 ([75Se]-labeled)
项目整合...
参考文献标题:13,14-Dehydro-11-deoxy-prostaglandins and process for their preparation
文献作者:Gandolfi,C.; Pellegata,R.Fumagalli,A.(Pharmacia & Upjohn SpA)
参考来源:US 4293705

DiacDAG, DADAG

二去氢-3,4-二乙酰基半乳糖醇Chemical Name: 1,2:5,6-Dianhydrogalactitol diacetate
CAS No. 57230-48-5
项目整合开发状态: Phase II
项目研究机构: Chinoin (Originator)
合成路线:Treatment of DAG (I) with acyl halides gave the...
参考文献标题:Acyldinahydrohexitol derivs.
文献作者:David,A.; Eckhardt,S.; Elekes,I.; Institoris,L.; Irag,S.; 謙v,L.; Somfai,Z.; Sugar,J.; Szabolcs,A.(Chinoin Pharmaceutical and Chemical Works Co.,Ltd.)
参考来源:DE 2557033; GB 1490649

Diflunisal, MK-647, Dolobid

二氟尼柳Chemical Name: 2',4'-Difluoro-4-hydroxy-1,1'-biphenyl-3-carboxylic acid; 2-Hydroxy-5-(2,4-difluorophenyl)benzoic acid
CAS No. 22494-42-4
项目整合开发状态: Launched-1978
项目研究机构: Merck & Co. (Origi...
参考文献标题:Halo-substituted 5-phenylbenzoic acids and their derivatives
文献作者:Ruyle,W.V.; et al.(Merck & Co.,Inc.)
参考来源:GB 1175212

Diflorasone, Psorcon, Maxiflor, Florone

二氟拉松Chemical Name: (6alpha,11beta,16beta)-6,9-Difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
CAS No. 2557-49-5
项目整合开发状态: Not Determined
项目研究机构:
合成路线:The 16beta-methyl p...
参考文献标题:
文献作者:Lincoln,F.H.; et al.
参考来源:US 3557158

Diflomotecan, R-1536, BN-80915

二氟替康二氟替康 Chemical Name: (+)-5(R)-Ethyl-9,10-difluoro-5-hydroxy-4,5,13,15-tetrahydro-1H,3H-oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione
CAS No. 220997-97-7, 186668-70-2 (undefined isome...
参考文献标题:Optically pure camptothecin analogues,optically pure synthesis intermediate and method for preparing same
文献作者:Cazaux,J.-B.; Manginot,E.; Lavergne,O.; Le Breton,C.; Bigg,D.(SCRAS (Societ?de Conseils de Recherches et d'Applications Scientifiques))
参考来源:EP 1007527; FR 2768431; WO 9911646

Diclofurime, ANP-4364

二氯呋利Chemical Name: (E)-1-(2,3-dichloro-4-methoxyphenyl)-1-(2-furyl)methanone O-[2-(diethylamino)ethyl]oxime
CAS No. 64743-08-4
项目整合开发状态: Not Determined
项目研究机构:
合成路线:By reacting (2,3-dichl...
参考文献标题:Etude de la configuration d磑ximes a activit?cardiotrope
文献作者:Laforest,J.; Thuillier,G.
参考来源:J Heterocycl Chem 1977,14793

3 HMP

二溴-三氯二苯并呋喃Chemical Name: 3-Hydroperoxy-3-methyl-1(3H)-isobenzofuranone
CAS No. 90094-81-8
项目整合开发状态: Biological Testing
项目研究机构: University of Toronto (Originator), University of Western Ontari...
参考文献标题:3-HMP
文献作者:Killackey,B.A.; Killackey,J.J.F.; Philp,R.B.
参考来源:Drugs Fut 1985,10(7),557

Bicyclomycin, Bicozamycin, CGP-3543/E, Bacteron

二环霉素Chemical Name: (1S,6R)-6-Hydroxy-5-methylene-1-[(1S,2S)-1,2,3-trihydroxy-2-methylpropyl]-2-oxa-7,9-diazabicyclo[4.2.2]decane-8,10-dione
CAS No. 38129-37-2
项目整合开发状态: Biological Testing
项目研...
参考文献标题:Total synthesis of bicyclomycin
文献作者:Nakatsuka,S.I.; Goto,T.
参考来源:Heterocycles 1984,21(1),61-73

FG-9202, NBQX

二羟基喹酮Chemical Name: 2,3-Dihydroxy-6-nitro-7-sulfamoylbenzo[f]quinoxaline
CAS No. 118876-58-7
项目整合开发状态: Phase I
项目研究机构: Ferrosan A/S (Originator), Schering AG (Originator), ZymoGenetics (Licen...
参考文献标题:Heterocyclic cpds.and their preparation and use
文献作者:Jacobsen,P.; Nielsen,F.E.; Honore,T.(Ferrosan A/S)
参考来源:AU 8813260; EP 0283959; US 4889855; US 4912108

Diaziquone, CI-904, NSC-182986, AZQ

亚丝醌Chemical Name: Diethyl 2,5-bis(1-aziridinyl)-3,6-dioxo-1,4-cyclohexadiene-1,4-dicarbamate; 2,5-Diaziridinyl-3,6-bis(ethoxycarbonylamino)-1,4-benzoquinone; [2,5-Bis(1-aziridinyl)-3,6-dioxo-1,4-cyclo...
参考文献标题:Aziridinyl quinone anti-transplanted tumor agents
文献作者:Driscoll,J.S.; et al.(US Department of Health & Human Services)
参考来源:US 4146622