合成路线:The reaction of chloranil (I) with ethyl carbamate (II) by means of Na in dry benzene gives 2,5-dichloro-3,6-bis(ethoxycarbonylamino)-1,4-benzoquinone (III),which is then condensed with aziridine (IV) by means of triethylamine in THF.
参考文献标题:AZQ
文献作者:Cabanillas,F.; Blancafort,P.; Serradell,M.N.; Castar,J.
参考来源:Drugs Fut 1981,6(6),338
合成路线:The reaction of chloranil (I) with ethyl carbamate (II) by means of Na in dry benzene gives 2,5-dichloro-3,6-bis(ethoxycarbonylamino)-1,4-benzoquinone (III),which is then condensed with aziridine (IV) by means of triethylamine in THF.
参考文献标题:Potential central nervous system antitumor agents.Azirinylbenzoquinones.1
文献作者:Kahn,A.H.; Driscoll,J.S.
参考来源:J Med Chem 1976,19(2),313-317
合成路线:The reaction of chloranil (I) with ethyl carbamate (II) by means of Na in dry benzene gives 2,5-dichloro-3,6-bis(ethoxycarbonylamino)-1,4-benzoquinone (III),which is then condensed with aziridine (IV) by means of triethylamine in THF.
参考文献标题:
文献作者:Zubrod,C.G.; Rall,D.P.
参考来源:Anu Rev Pharmacol 1962,2109
合成路线:The reaction of chloranil (I) with ethyl carbamate (II) by means of Na in dry benzene gives 2,5-dichloro-3,6-bis(ethoxycarbonylamino)-1,4-benzoquinone (III),which is then condensed with aziridine (IV) by means of triethylamine in THF.
参考文献标题:Structure-antitumor activity relationships among quinone derivatives
文献作者:Driscoll,J.S.; et al.
参考来源:Cancer Chemother Rep 1974,4(2),1
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