项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Vibunazole, Bay-n-7133

alpha-叔-丁基-Alpha-[(4-氯苯氧基)甲基]-1H-1,2,4-三唑-1-乙醇Chemical Name: alpha-[(4-Chlorophenoxy)methyl]-alpha-(1,1-dimethylethyl)-1H-1,2,4-triazole-1-ethanol; 1-(4-chlorophenoxy)-3,3-dimethyl-2-(1,2,4-triazol-1-...
参考文献标题:BAY-N-7133
文献作者:Fromtling,R.A.; Serradell,M.N.; Castar,J.
参考来源:Drugs Fut 1984,9(6),404

BD-1047

BD 1047二氢溴酸Chemical Name: N1-[2-(3,4-Dichlorophenyl)ethyl]-N1,N2,N2-trimethyl-1,2-ethanediamine
CAS No. 138356-20-4
项目整合开发状态: Preclinical
项目研究机构: National Institutes of Health (Originator), P...
参考文献标题:N-(Arylethyl)-N-alkyl-2-(1-pyrrolidinyl)ethylamine derivs.for CNS disorders
文献作者:De Costa,B.R.; Radesca,L.; Bowen,W.; Long,J.; Walker,J.M.; Rice,K.C.; Gray,N.M.; Contreras,P.C.(Pharmacia Corp.)
参考来源:EP 0518216; WO 9222279

Maribavir, Benzimidavir, GW-257406X, GW-1263, BW-1263W94, 1263W94

BENZIMIDAVIR 苯并咪唑核苷Chemical Name: 5,6-Dichloro-2-(isopropylamino)-1-(beta-L-ribofuranosyl)-1H-benzimidazole
CAS No. 176161-24-3, 176161-49-2 (alpha-L-anomer)
项目整合开发状态: Phase II
项目研究机构: GlaxoS...
参考文献标题:Therapeutic cpds
文献作者:Chamberlain,S.D.; Koszalka,G.W.(Glaxo Wellcome plc)
参考来源:EP 0769017; JP 1998502356; US 6077832; WO 9601833

新产品编号:948127

BMS470539二盐酸盐Chemical Name: 1-[1-(Ntau-Methyl-L-histidyl-O-methyl-D-tyrosyl)-4-phenylpiperidin-4-yl]butan-1-one; N1-[2-(4-Butyryl-4-phenylpiperidin-1-yl)-1(R)-(4-methoxybenzyl)-2-oxoethyl]-Ntau-methyl...
参考文献标题:Cpds.useful as modulators of melanocortin receptors and pharmaceutical compsns.comprising same
文献作者:Poindexter,G.S.; Ruediger,E.H.; Ruel,R.; Lawrence,R.M.; Yu,G.; Macor,J.; Morton,G.C.; Thibault,C.; Herpin,T.(Bristol-Myers Squibb Co.)
参考来源:EP 1363631; EP 1363898; WO 0270511; WO 0279146

BQ-788

BQ-788 钠盐Chemical Name: N-(cis-2,6-Dimethylpiperidin-1-ylcarbonyl)-L-(4-methyl)leucyl-D-(N1-methoxycarbonyl)tryptophyl-D-norleucine sodium salt
CAS No. 156161-89-6
项目整合开发状态: Phase I
项目研究机构: B...
参考文献标题:Endothelin antagonistic substance
文献作者:Ishikawa,K.; Fukami,T.; Nagase,T.; Mase,T.; Ihara,M.; Yano,M.; Nishikibe,M.(Banyu Pharmaceutical Co.,Ltd.)
参考来源:EP 0555537; JP 1994107680

CDDO-Im, CDDO-Imidazolide

CDDO咪唑Chemical Name: 28-(1H-Imidazol-1-yl)-3,12,28-trioxooleana-1,9(11)-diene-2-carbonitrile ; 1-[2-Cyano-3,12,28-trioxooleana-1,9(11)-dien-28-yl]-1H-imidazole
CAS No. 443104-02-7
项目整合开发状态: Prec...
参考文献标题:Inhibitors and methods of use thereof
文献作者:Honda,T.; Honda,Y.; Gribble,G.W.; Sporn,M.B.; Suh,N.(Dartmouth College)
参考来源:US 2004002463

JTT-705

CETP抑制剂Chemical Name: 2-Methylpropanethioic acid S-[2-[1-(2-ethylbutyl)cyclohexylcarboxamido]phenyl] ester
CAS No. 211513-37-0
项目整合开发状态: Phase II
项目研究机构: Japan Tobacco (Originator), Roche (Li...
参考文献标题:CEPT activity inhibitors
文献作者:Maeda,K.; Okamoto,H.; Shinkai,H.(Japan Tobacco Inc.)
参考来源:EP 1020439; JP 1999049743; JP 1999222428; WO 9835937

M-30

cis-N-(十氢2-甲基-5-异喹啉)-3,4,5-三甲氧基苯并胺Chemical Name: (4aalpha,5beta,8aalpha)-N-(Decahydro-2-methyl-5-isoquinolinyl)-3,4,5-trimethoxybenzamide; cis-5-(3,4,5-Trimethoxybenzamido)-2-methyldecahydroisoquinoli...
参考文献标题:Benzamido 2 lower alkyl decahydroisoquinolines
文献作者:Mathison,I.W.(Aventis Pharmaceuticals,Inc.)
参考来源:DE 1900948; FR 2004748; GB 1246051; JP 7114060; US 3674791

Dronabinol hemisuccinate, THC-HS, ONP-04

delta9-四氢大麻酚半琥珀酸酯Chemical Name: 4-[(6aR,10aR)-6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-dibenzo[b,d]pyran-1-yloxy]-4-oxobutyric acid; DELTA9-Tetrahydrocannabinol hemisuccinate
CAS No. 52855...
参考文献标题:Method of preparing delta-9-tetrahydrocannabinol esters
文献作者:Elsohly,M.A.; Ross,S.A.; Feng,S.(University of Mississippi)
参考来源:GB 2358397; US 6008383; WO 0029402

Acyline

D-阿拉尼胺,N-乙酰-3-(2-萘基)-D-丙烯基-4-氯-D-苯丙二酰-3-(3-吡啶基)-D-丙烯酰-L-丝基-4-(乙酰氨基)-L-苯丙酰-4-(乙酰氨基)-D-苯丙酰-L-白基-N6-(1-甲基乙基)-L-赖基-脯氨酰-Chemical Name: Acetyl-2-naphthyl-D-alanyl-4-chloro-D-phenylalanyl-3-pyridyl-D-alanyl-...
参考文献标题:GnRH antagonists
文献作者:Rivier,J.E.F.; Porter,J.S.; Hoeger,C.A.; Jiang,G.; Rivier,C.L.(The Salk Institute for Biological Studies)
参考来源:EP 0804471; JP 1998500397; US 5506207; WO 9525741