Vibunazole, Bay-n-7133
alpha-叔-丁基-Alpha-[(4-氯苯氧基)甲基]-1H-1,2,4-三唑-1-乙醇Chemical Name: alpha-[(4-Chlorophenoxy)methyl]-alpha-(1,1-dimethylethyl)-1H-1,2,4-triazole-1-ethanol; 1-(4-chlorophenoxy)-3,3-dimethyl-2-(1,2,4-triazol-1-yl)methyl-2-butanol; 2-[(4-Chlorophenoxy)methyl]-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butan-2-ol
CAS No. 80456-55-9
项目整合开发状态: Phase III
项目研究机构: Bayer (Originator)
合成路线:The reaction of 1-(4-chlorophenoxy)-3,3-dimethyl-2-butanone (I) with dimethyl sulfide,dimethyl sulfate and sodium methoxide in acetonitrile gives 2,4-chlorophenoxymethyl)-2-(tertbutyl)oxirane (II),which is then condensed with 1,2,4-triazole (III) in refluxing ethanol.
📌 参考资料/链接：
参考文献标题:BAY-N-7133
文献作者:Fromtling,R.A.; Serradell,M.N.; Castar,J.
参考来源:Drugs Fut 1984,9(6),404
📄 详细内容
合成路线:The reaction of 1-(4-chlorophenoxy)-3,3-dimethyl-2-butanone (I) with dimethyl sulfide,dimethyl sulfate and sodium methoxide in acetonitrile gives 2,4-chlorophenoxymethyl)-2-(tertbutyl)oxirane (II),which is then condensed with 1,2,4-triazole (III) in refluxing ethanol.
参考文献标题:Oxirane compounds
文献作者:Holmwood,G.; Buechel,K.H.; Luerssen,K.; Frohberger,P.E.; Brandes,W.
参考来源:EP 0040345; EP 0072580; EP 0087148; ES 8203859; JP 2167270; JP 2167273; US 4532341; US 4626595; US 4723984; US 4789672; US 4871390; US 4897107; US 4904298; US 4911746
合成路线:The reaction of 1-(4-chlorophenoxy)-3,3-dimethyl-2-butanone (I) with dimethyl sulfide,dimethyl sulfate and sodium methoxide in acetonitrile gives 2,4-chlorophenoxymethyl)-2-(tertbutyl)oxirane (II),which is then condensed with 1,2,4-triazole (III) in refluxing ethanol.
参考文献标题:Antimicrobial azoles
文献作者:Holmwood,G.; Buechel,K.H.; Plempel,M.; Haller,T.
参考来源:DE 3018865; EP 0043419; JP 57009715; US 4652579
产品链接: CAS No. 80456-55-9››