Alendronic Acid CAS Registry Number: 66376-36-1 阿仑膦酸

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Literature References: Bisphosphonate antiresorptive agent. Prepn: M. I. Kabachnik et al., Bull. Acad. Sci. USSR, 27, 374 (1978). See also: BE 903519; G. Staibano, US 4705651 (1986, 1987 both to Gentili). Improved prepn: G. R. Kieczykowski et al., J. Org. Chem. 60, 8310 (1995). Pharmacokinetics: J. H. Lin et al., Drug Metab. Dispos. 19, 926 (1991). Mechanism of action: M. Sato et al., J. Clin. Invest. 88, 2095 (1991). Determn by HPLC in urine: W. F. Kline et al., J. Chromatogr. 534, 139 (1990); by IC in pharmaceutical formulations: E. W. Tsai et al., ibid. 596, 217 (1992). Clinical evaluation in malignant hypercalcaemia: R. Rizzoli et al., Int. J. Cancer 50, 706 (1992). Clinical trial in postmenopausal osteoporosis: U. A. Liberman et al., N. Engl. J. Med. 333, 1437 (1995); in prevention of bone loss in women: D. Hosking et al., ibid. 338, 485 (1998). Clinical trial in men with osteoporosis: E. Orwoll et al., ibid. 343, 604 (2000).